Objective To help the operator to find the alarm of Siemens StreamLab as quickly as possible. Methods Based on serial port control with VB 6.0 program, the system can catch the change of the control screen's special point and control the serial port to change the condition of the appointed pin to get a DC voltage to turn the LED on. Results The translation was implemented from screen icon alarm to LED alarm. Conclusion The LED alarm system can help the operator to observe the alarm of Siemens StreamLab promptly.

Objective To compare the serum thyroid hormones level in patients with pre-diabetes,newly diagnosed type 2 diabetes mellitus(T2DM)and healthy people,and to investigate the association of glucose metabolism with thyroid function.Methods Sixty newly diagnosed T2DM patients(T2DM group),60 pre-diabetes patients(pre-diabetes group),and 60 healthy people(healthy group) from outpatient departments were randomly enrolled in the study.Their thyroid peroxidase antibodies(TPOAb),thyroglobulin antibodies(TGAb),thyrotropin receptor antibodies(TRAb),and thyroid color dopplar ultrasound were all normal.Thyroid hormones was measured.Glycosylated hemoglobin A1c(HbA1c),fasting plasma glucose(FPG),glycated albumin(GA) was additionally measured in T2DM patients.We compared the difference of thyroid hormones among the 3 groups and investigated the factors that influence thyroid hormones level in each T2DM patients.Results There was no significant difference found on thyroid hormones level between the pre-diabetes group and healthy group(P＜0.05).T3 and FT3 level were(1.34±0.24)nmol/L and(3.88±0.51)pmol/L in the T2DM group,respectively,which were significantly lower than those in the pre-diabetes group([1.48±0.29]nmol/L and [4.12±0.55]pmol/L,t=-0.135 and -0.145,respectively,Ps＜0.01＝ and in the healthy group([1.49±0.26]nmol/L and [4.13±0.55]pmol/L,t=-0.240 and -0.260,respectively,P＜0.05 or 0.01) .In the T2DM group,T3 and FT3 were negatively correlated with FPG,GA,HbA1c(For T3:r=-0.275,-0.318 and -0.453,respectively,Ps＜0.05;For FT3:r=-0.280,-0.291 and -0.336 ,respectively,Ps＜0.05).Conclusion In patients with abnormal glucose metabolism, thyroid hormone was influenced only when the glucose metabolism level reached a certain abnormal degree.

Objective To investigate the association of leptin receptor gene Gln223Arg polymorphism with metabolism syndrome and insulin resistance. Methods The genotypes of leptin receptor in 167 patients with metabolic syndrome and 216 healthy subjects were determined by polymerase chain reaction restriction fragment length polymorphism. The biochemical indicators were detected. Results The frequency of A alleles was significantly higher in patients with metabolic syndrome than in healthy subjects. The risk of metabolic syndrome in inviduals with allele A was 3. 302 folds of that with allele G( P<0.01 ). Compared with allele G, the patients withA allele had higher body mass index,blood pressure, blood glucose, insulin level, waist circumference, and more serious dyslipidemia. The risk of insulin resistance in patients with A allele was 3. 446 folds of that with allele G (P<0.01). Conclusions Leptin receptor gene Gln223Arg polymorphism is associated with an increased risk of metabolic syndrome and insulin resistance.

Objective To investigate the therapeutic effects of alendronate combined with Caltrate D on regional bone mineral density (BMD) in elderly type 2 diabetic women with osteoporosis. Methods Thirty-four elderly type 2 diabetic women with osteoporosis aged 60-79 years (average 68. 0±4.5 years), with body mass index (BMI) of (25.0±3.7) kg/cm2 and duration of diabetes (8.9 ±4.4) years were enrolled. At the basis of a comprehensive management, the patients were treated with alendronate combined with Caltrate D for 6 months. BMD of the lumbar spine and hip, several biochemical indexes were measured before and after treatment. Results After the 6 months treatment, the BMD of different regions at lumbar spine and hip all increased. The T value and BMD were significantly higher at lumbar spines than at hip (both P＜0.01). The differences of T value and BMD of different regions were significant (P = 0.003 and 0.005,respectively). BMD percent change at lumbar spine were L4 (44.7%) ＞ L3 (31.9%) ＞ L total (27.3 % ) ＞ L1 (20.0%) ＞ L2 (14.3 % ), and the BMD percent changes were significantly higher in L3 and L4 than in other regions at lumbar spine (P=0. 038 and 0. 008, respectively). The changes of T value and BMD were significantly higher in L3, L total, L1 and L4 than in L2 (T value: P=0. 036,0. 042, 0. 006 and 0. 004, respectively; BMD: P=0. 002, 0. 002, 0. 003 and 0. 001, respectively).Conclusions On the basis of comprehensive management, the 6 months treatment with alendronate combined with Caltrate D in elderly type 2 diabetic women with osteoporosis may achieve good therapeutic effect at lumbar spines, especially at the lower lumbar spines, while less effective at hip.

Child ; Esophagus ; pathology ; Foreign Bodies ; diagnosis ; Humans

Objective To determine the relationship between the content of microelement and the health of children.Methods Atomic absorption spectrometry,aas.Children were divided into 3 groups:physically weak group,minimal brain dysfunction(MBD) group and control group.Peripheral blood gathered from all the children.Put 40?l of blood sample into the specific reagent,detect the content of zinc(Zn),cuprum(Cu),ferret(Fe),calcium(Ca),magnesium(Mg),lead(Pb),cadmium(Cd).The result was compared between the 3 groups.Results Lack of Zn,Fe,Ca and Mg mostly be detected in physically weak group(P

Objective To explore coping strategies and influence factors in primary glaucoma patients through describing characteristics of their coping strategies.Methods From November 2007 to June 2008,data were collected from 120 primary glaucoma patients in three hospitals in Guangzhou and Shenzhen.The final sample consisted of 100 patients and the data underwent analysis.Results Among different coping styles of primary glaucoma patients,facing was lower than norm,avoiding and yielding were higher than norm.The factors related to coping style were age,different cohabitant,different economic condition,different occupation,different educational level and health payment mode.Conclusions Primary glaucoma patients usually took avoiding or yielding coping styles.Nurses should help patients with low income and education background to face the disease positively.Besides,fully consideration should be given to patients with different age,at the same time,marriage and family support should also exert active function.

Objective: To explore the relationship between 1eptin receptor gene Gln223Arg polymorphism and metabolism syndrome (MS) with its impact on cardiac structure and function.
Methods: Our research included 2 groups:MS group, n=167 patients with ifrst diagnosed MS without treatment in our hospital from 2005-10 to 2008-6 and Control group, n=216 healthy subjects from regular physical examination. Blood pressure, biochemical features, insulin levels and echocardiography were detected;leptin receptor Gln223Arg genotypes were measured by PCR-RFLP;the above indexes were compared between 2 groups.
Results:The patients in MS group had the higher frequency of A allele than Control group. The MS occurrence rate in allele A carrier was 3.302 times higher than allele G carrier (P=0.000;95%CI 2.432-4.483). The patients in MS group already had left ventricular hypertrophy and impaired diastolic function. Compared with MS G allele carriers, the A allele carriers had the higher BMI, blood pressure, glucose, fasting glucose and insulin levels, longer waist circumference, more serious dyslipidemia and insulin resistance, left ventricular hypertrophy and impaired diastolic function.
Conclusion: Leptin receptor gene Gln223Arg polymorphism is associated with the increased risk of MS occurrence and left ventricular hypertrophy.

Objective To investigate the correlation between leptin receptor(LEPR)gene Gln223Arg variation with metabo-lism syndrome and its influence on ambulatory blood pressure .Methods Totally 167 patients with metabolism syndrome were se-lected and contemporaneous 216 individuals undergoing the physical examination were selected as the control group .The blood pres-sure ,ambulatory blood pressure ,biochemical indicators and insulin were detected in all the subjects .The DNA polymorphology a-nalysis was performed by adopteint PCR—restricted fragment length polymorphism(RFLP) .The Gln223Arg genotype was judged by electrophoresis and sequencing .Results Three genotypes of AA ,GG and AG were detected .The frequency of carrying A alleles in the metabolism syndrome group was significantly higher than that in the control group .The occurrence risk of metabolism syn-drome and non—dipper type blood pressure rhythm for carrying allele A was 3 .302 times(P=0 .000;95% CI:2 .432 —4 .483)and 2 .506 times of carrying allele G(P=0 .000 ;95% CI:1 .566 —4 .008) .The patients with AA genotype had higher BMI ,blood pres-sure ,blood glucose and fasting insulin levels ,more serious dyslipidemia ,greater waist circumference and higher insulin resistance in-dex .The patients with metabolism syndrome carrying A allele also had higher ambulatory blood pressure indexes .Conclusion LEPR gene Gln223Arg polymorphism A allele carrier has the great risk for metabolism syndrome occurrence ,higher ambulatory blood pressure ,moreover is more inclined to non—dipper type blood pressure rhythm .

Objective To investigate the relationship between the resistance of the Klebsiella pneumoni-ae and the Klebsiella pneumoniae plasmid pNDM-LJ carrying blaNDM-1 by high-throughput DNA sequencing. Methods High-throughput DNA sequencing was carried out by the Illumina Miseq platform , and sequencing data were assembled by Edena software. Contigs were annotated by the RAST server and analyzed by the BLAST server. Results The plasmid pNDM-LJ was 54-kb in size with a GC content of 49%. The plasmid encoded 52 putative functional genes and belonged to the IncX3 group in incompatible classifications. Analysis of the plasmid sequence revealed high similarity with other IncX3 plasmids. The blaNDM-1 gene was located in a complicated gene environment possibly constructed by several transposition events. The 5′ and 3′ ends of the blaNDM-1 gene were adjacent to the ISAba125 and IS 26 respectively , forming a 10.8-kb transposon-like structure. Conclusion The plasmid pNDM-LJ carried the blaNDM-1 gene being resistant to carbapenems and played a possibly impor-tant role in transmission of blaNDM-1 in China.