Objective To study the effect of fissure sealant combined with fluorine-containing gel in the prevention of dental caries in children.Methods Totally 86 cases who came into our hospital for healthy check-up from June 2010 to June 2011 were slected,and they were divided into 3 groups according to a random number table.Children in fissure sealant group were given fissure sealant treatment,children in combined treatment group were given fluorine gel treatment in addition of fissure sealant,and children of the control group were given rou-tine oral care.Observed the caries average,adjacent surface caries and caries occurrence of the three groups,and observed the blocking agent of the fissure sealant group and the combined treatment group.Results Three years after the prophylactic treatment,the caries occurrence, adjacent surface caries and caries average of fissure sealant group and combined treatment group showed an obvious downward trend compared with those of the control group.But the caries occurrence,adjacent surface caries and caries average of combined treatment group were sig-nificantly lower than the fissure sealant group,with a statistically significant difference(P <0.05).In the follow-up of the first two years,the complete preservation rate of sealant in the combined treatment group was significantly higher than the fissure sealant group,while the partial and complete loss rate of sealant in the combined treatment group was significantly lower than the fissure sealant group,and the difference was statistically significant (P <0.05).Conclusion Fissure sealant combined with fluorine-containing gel in the prevention of dental caries in children can receive good results,and it is worth of promotion.

Objective To investigate the effect of cognitive behavior therapy combined with drug treatment of adolescent obsessive-compulsive disorder(OCD) and the effect on quality of life.Method Yale Brown Obsessive Compulsive Scale (Y-BOCS) and quality of life in children and adolescents scale (QLSCA) were used to assess the curative effect and quality of life for 123 adolescents with OCD on the psychological clinic in hospital.t test and one way-ANOVA test were used to analyze the data.Results The effective rate of drug treatment group was 64.52％ after 12 weeks and combined treatment group was 80.33％.The effective rate of drug treatment group was 77.42％ after 24 weeks and combined treatment group was 91.8％.There was significant difference between the two groups (P ＜ 0.05).Two groups before and after treatment had significant difference (P ＜ 0.01).There was significant difference between the two groups after 12 weeks (P＜ 0.01) and 24 weeks (P ＜ 0.05).After 24 weeks of treatment,two groups of patients in the overall evaluation of the quality of life and negative ernotion had significant differences (P ＜ 0.05) and in self satisfaction,peer relationship,learning ability and attitude had significant differences (P ＜ 0.01).Conclusion Combination therapy is better than simple drug treatment,and improves the quality of life better.

Objective Discuss the treatment effect of sodium ferulate,deproteinized calf serum and high pressure oxygen on acute carbon monoxide poisoning.Methods Seventy-five cases with coma acute carbon monoxide poisoning were randomly divided into two groups:the treated group (37 cases) and the control group (38 cases).The two groups were treated with high pressure oxygen,high flow oxygen uptake and support treatment,The treated group were treated with sodium ferulate and deproteinized calf serum.The control group were treated with citicoline act medicaments.Result The occurrence and injury degree of myocardial damage and delayed encephalopathy were markedly attenuated (P ＜ 0.05),the time of coma was obviously decreased (P ＜0.01),the death rate was obviously difference (P ＜0.05) in the treated group compared with the control group.Conclusion Sodium ferulate,deproteinized calf serum injection possess obviously effect on acute carbon monoxide poisoning.

Objective To investigate the soft contact lens related knowledge and wearing behaviors.Method Two hundred outpatients in the ophthalmologic clinic wearing SCL involved in the survey by the questionnaire to investigate the SCL-related knowledge and the wearing behaviors.Results In the 200 SCL wearer,73.50% did not make any examinations by specialists and only 18.00% of them took regular examinations.The wearers were good at the knowledge of selecting SCL diopter and positive and negative lens.The wearers with a history of less than 6 months were better than those wearing SCL more than 6 months in respect of hand cleaning,lens check,lens wearing, and lens cleaning.The wears with the education of two-year vocational training were significantly better than those with the education of three-year or more collegiate training in respect of wearing duration,sleep with lens,hand cleaning and lens cleaning(all P<0.05).Conclusion Contact lens wearers know less about SCL related knowledge and their wearing behaviors needs improvement.

Clinical data of 129 young pafienm with lung cancer were analyzed retrospectively.Adenocarcinoma was the main pathologic type of lung cancer(n=62,48.1%),followed by undifferentiated small cell carcinoma(n=35,27.1%),squamous carcinoma(n=20,15.5%).Forty four cases were misdiagnosed at first consultation with a misdiagnosis rate of 34.1%.To avoid misdiagnosis seems to be the key issue for improvement of prognosis in young patients with lung cancer.

Objective As estrogen increases visceral hypersensitivity induced by water avoidance stress in female rats,further experiment was designed to determine whether the influence of estrogen involves NR2B.Methods Healthy adult female Wistar rats were bilaterally ovariectomized,and then housed individually.Implantation of cannula into lateral cerebroventricle and electrodes into the abdominal muscle had been done.After 5 days recovery,rats with abnormal behavior and ehctromyography were excluded,finally a total of 48 rats were eligible,and were equipped for abdominal muscle electromyography and submitted to water avoidance stress(WAS).Visceromotor response(VMR)to 20,40,60 and 80 mmHg colorectal distension(CRD)was recorded in rats intracerebroventricular-infused with either 17β-estradiol,normal saline,AP5(NMDA receptor-antagonist)or Ro25-6981(NR2B antagonist).NR2B mRNA in anterior cingulate cortex or dorsal root ganglia were compared by real-time PCR between the rats treated with 17β-estradioI and that with normal saline.Results Bilaterally ovarieetomized rats treated with 17β-estradiol,exhibited more visceral hypersensitivity after WAS than that with normal saline on 40,60 and 80 mmHg CRD(P=0.039,P=0.033,P=O.001).The VMR on 40 and 60 mmHg CRD in 17β-estradiol treated group was not significantly different from that in 17β-estradiol plus Ro25-6981 treated group.Whilst,significant differences of VMR were noted between 17β-estradiol treated group and 17β-estradiol plus Ro25-6981 treated group on 80 mmHg CRD,17β-estradiol treated group and 17β-estradiol plus AP5 treated group on 60,80 nmmHg CRD,respectively.17β-estradiol increased NR2BmRNA in anterior cingulate cortex(0.57±0.41 vs 0.21±0.13,P=0.048),but not in dorsal root ganglia(0.35±0.45 vs 0.38±0.31,P=0.465). Stress-induced visceral hypersensitivity in the hormonally-restored visceral hyper-responsiveness of bilaterally ovariectomized rats was antagonized by AP5 or Ro25-6981.Conclusions Estrogen may be mediated through NR2B activation to enhance visceral sensitivity in female stressed rats,that probably related with the increased expression of NR2B mRNA in anterior cingulate cortex.

OBJECTIVE: To study the how's for pharmacists at inpatient pharmacy to provide pharmaceutical care for improved safe and effective use of drugs. METHODS: Pharmacists at inpatient pharmacy can provide pharmaceutical care as per specific clinical needs, and start from such details as preparing the booklet of commonly-used chemotherapy drugs, offering face-to-face advises on drug use for diabetics, and helping nurses to manage the medicine cabinets. RESULTS & CONCLUSION: Pharmacists at inpatient pharmacy should provide the right pharmaceutical care that can meet actual clinical needs.

Objective To approach the changes of serum insulin and peptide C and determine their relationship with inflammatory reaction in patients with severe multiple trauma. Methods The serum insulin, peptide C, tumor necrosis factor (TNF)-α, interleukin (IL)-10, C reactive protein (CRP) were detected in 30 patients with severe multiple trauma at days 1,3 and 7 after trauma to analyze the dynamic changes of serum insulin and peptide C and their correlations with Acute Physiology and Chronic Health Evaluation Ⅲ ( APACHE Ⅲ), cytokines and CRP. The changes of cytokines and CRP were also compared with those of serum insulin and peptide C in patients with different outcomes. The changes of serum insulin and peptide C of 35 healthy subjects were detected and used as control. Re-sults The serum insulin and peptide C levels of patients were higher than those in control group at each time point after trauma, with remarkably positive correlation with APACHE Ⅲ. Whether the serum glu-cose and age were controlled or not,serum insulin and peptide C were positively correlated with IL-10 at each time point and with TNF-α and CRP at days 3 and 7. The levels of serum insulin, peptide C and IL-10 were decreased with time in both groups with different outcomes. Meanwhile, the levels of TNF-α and CRP were decreased in the survival groups but increased in the death groups. The levels of above indices in death group were significantly higher than survival groups at the same time point. Conclusions The increasing of serum insulin and peptide C is correlated with inflammatory reaction after severe multiple trauma. The dynamic changes of both indices can either reflect injury severity or be used as an effective index in dynamically monitoring anti-inflammatory degree of the organism.

Some anti -scientific views on cancer treatment on network have serious adverse effects on some cancer patients:impacting the health promotion , patients′compliance , patients′positive psychology , patients′so-cial supports and people′s correct understanding to medical staff .And put forward the following two solutions to this effect:improve medical science website , improve the understanding of cancer prevention and control of masses , hired authoritative expert lectures on site or television , government , medical institutions and hospitals should ac-tively resist vulgar anti-science view , shoulder the moral responsibility .

Objective To design a new type of field operation instrument for easy to spread a rescue surgery rapidly in field first -aid at the present stage. Methods The traditional field operation instrument set is innovated in its composition, structure and function. The packing instrument procedure can be omitted. The new field operation instrument set is made of four different operation instrument boxes, two of which can be put into a standard field medical case. Results It is designed to be convenient to have a rescue surgery rapidly and to be washed, sterilized, conveyed and kept in aseptic storage. Conclusion The new field operation instrument case has such advantages as compactness, reasonable allocation and function completed, so it can be used easily.