Ursolic acid, a pentacyclic triterpene compound, naturally occurs in a large variety of plants, has at-tracted considerable interest owing to its significant biological activities. In recent years, more and more scientists have been working on the structural modification at the C-3 position , C_(12)-C_(13) double bond or C-28 position of ur-solic acid in order to improve their biological activities. Herein a brief introduction of the recent progresses on the chemical structural modification and the structure-activity relationship of ursolic acid and its derivatives are re-viewed.

Objective To investigate the clinical effect of coracoclavicular ligament reconstruction by getting tendon palmaris longus for treating acromioclavicular joint dislocation under arthroscopically assisted Endobutton steel plate fixation.Methods Eighteen patients with acute closed acromioclavicular joint dislocation treated in this hospital from January 2013 to March 2015 were selected and treated by coracoclavicular ligament reconstruction by getting tendon palmaris longus and double Endobutton steel plate fixation under arthroscopy.The visual analogue scale(VAS) was adopted before and after operation.The Karlsson treatment effect score was adopted at the end of follow up period.The patients satisfaction was investigated.Results The wounds in 18 cases were stage Ⅰ first grade healing and the reduction of acromioclavicular joint dislocation was good.The postoperative VAS score was(0.56±0.62) points,which was significantly decreased compared with(2.44± 1.20) points before operation(t=5.945,P＜0.01).During the follow-up visit,1 case appeared dislocation recurrence and treated by adopting clavicle hook plate fixation;average follow up time was 17.72 months,the Karlsson score at the end stage was excellent in 12 cases,good in 5 cases and poor in 1 case,the excellent and good rate was 94.44 ％,the patient satisfaction degree was 88.89 ％.Conclusion Arthroscopically assisted Endobutton steel plate fixation combined with ligament reconstruction by tendon palmaris longus for treating acromioclavicular joint dislocation has small trauma and reliable fixation,and promotes the joint function recovery.

Antineoplastic Agents ; chemistry ; pharmacology ; Carcinoma, Hepatocellular ; drug therapy ; immunology ; pathology ; Cytokines ; immunology ; Drug Screening Assays, Antitumor ; Glypicans ; antagonists & inhibitors ; immunology ; Humans ; Ligands ; Liver Neoplasms ; drug therapy ; immunology ; pathology ; T-Lymphocytes ; drug effects ; immunology