Objective To study the effect of an angiogenesis inhibitor TNP-470 (TNP )used alone and in combination with cytoxan(CTX) in the treatment of human ovarian cancer transplanted s.c. in nude mice. Methods Human ovarian cancer transplanted s.c. in nude mice model was established, then divided into 5 groups: control group, vehicle group, TNP group,CTX group and TNP+CTX group, different treatments were served from day 8 after transplantation and all mice were sacrificed after 28 days. The weights of the mice and the volumes of the tumors were measured respectively during the therapy time. Moreover, microscopy was done after H&E staining. Results The growth inhibiting rates in the TNP and CTX group were 26.1% and 33.9% respectively; After combined, the rate was increased to 70.5%. There were no obvious decrease in the weight of all treated mice. Conclusions Treatment with TNP is an potentially useful method of antitumor therapy in ovarian cancer, although the inhibition effects were not obvious in small doses. Moreover,TNP could enhance the effectiveness of antitumor drug.

[Summary] The paper reported perioperative respiratory nursing experience of 31 patients with emphysema complicating pneumothorax treated with lung volume reduction surgery under video-assisted thoracoscopy .The thoracoscopic surgery was completed in 27 patients and conventional thoracotomy were required in 4 patients because of severe pleural cavity adhesions .No severe respiratory complications occurred in all the patients .We deemed that positive preoperative mental nursing , respiratory preparation and exercises, proper physical training , intraoperative prevention of hazardous inhalation , postoperative effective analgesia , and careful management of closed thoracic drainage are key points of perioperative nursing .

AIM:To observe the effect of motilium on bronchial asthma associated with gastroesophageal reflux(GER BA). METHODS:50 cases of GER BA, were treated with routine anti asthma and motilium 20 mg tid,ranitidine 0.3 g,amoxicillin 0.5 g and metronidazolum 0.2 g tid for chronic gastritis cases, and losec 20 mg for the gastric acid rdflux at night. The treatment lasted for 1-4 wk, and then stopped to observe the response of the treatmeat. The recurrent cases would be treated as the above again. RESULTS:45 cases were cured in the 4 wk,no case recrudesced in 6 mon. 5 cases needed another the treatment for 1-4 wk since the recurrence, and 4 of the 5 cases were cured. CONCLUSION: Motilium has a good curative effect in preventing and curing bronchial asthma associated with gastroesophageal reflux.entfor1 -4wksin

Objective To reduce infection risk in hemodialysis patients through analyzing the causes of over stand-ard colony forming unit(CFU)and conducting bacteriological detection of hemodialysis concentrated B solution. Methods According to microbial monitoring results of hemodialysis concentrate B solution in a hospital between November 2011 and May 2012,disinfection frequency of B solution was changed and dispensing container was covered during the process of using,four groups were divided according to different measures (group A disinfected twice a week,covered dur-ing the process of using;group B twice a week;group C once a week;group D once every two weeks),monthly bacte-riological detection of B solution was conducted,condition before and after disinfection of four groups were com-pared.Results Bacterial count in group A,B ,C and D was(25.41 ±15.08),(28.24±28.04),(68.58 ±22.58), and (75.25±26.63)CFU/mL,respectively (F =79.00,P <0.01 );bacterial count of group A,B,and C after in-tervention were all lower than group D before intervention (all P <0.01),bacterial count of group A and B was the lowest.The qualified rate of group A was 100.00%,the unqualified rate of group B,C,and D was 13.95%, 24.24%,and 35.94% respectively(χ2 =28.70,P <0.01 ),the unqualified rates of group A,B,and C after inter-vention were all lower than group D.Conclusion Hemodialysis concentrated B solution should be used within 24 hours after preparing,disinfected twice a week,and covered during the process of using ,so as to control B solution colony number within the standard level.

Objective To study normal hearing children's speech perception in Speech Spectrum -Shaped Noise (SSN) and Babble Noise (BN) using the Mandarin lexical neighborhood test .Methods Thirty -four children with normal hearing were included in this study and randomly assigned to the SSN group and the BN group .Each child was given the 12 lists of Mandarin lexical neighborhood test ,word recognition scores were acquired at different SNRs .Results SNR50 of dissyllablic easy word lists ,dissyllablic hard word lists ,monosyllable easy word lists , monosyllable hard word lists in SSN were -3 dB ,-0 .5 dB ,-1 dB and 3 .5 dB ,respectively ;SNR50 of the four categories lists in BN were -3 dB ,2 dB ,0 .5 dB and 10 dB ,respectively .Lexical effects had a significant influence on spoken word recognition in noise .Especially ,word recognition scores of easy words were higher than those of hard words ,dissyllablic words were better than monosyllable words .Conclusion The masking effects of babble noise on spoken speech perception are stronger than speech spectrum -shaped noise for 3-6 year-old normal hearing chil‐dren .Lexical effects also affet children's speech recognition in noise .

Objective To explore the impact of pre-implant hearing aid fitting on the early open-set word recognition in children who received a cochlear implant(CI) when they were infants .Methods A total of 289 chil‐dren who received a cochlear implant between 0 .9 and 3 .0 years of age were included in this study .According to pre-implant hearing aid fitting ,participants were divided into hearing aid group and non-hearing aid group .The open-set word identification abilities of the cochlear implant children were evaluated via Mandarin Lexical Neighborhood test(M -LNT) .Results Comparisons of the scores of M -LNT between two groups displayed no significant differ‐ence at the same identification age or duration of CI use .Conclusion The abilities of the early open-set word rec‐ognition between hearing aid group and non-hearing aid group didn’t make significant differences for the CI chil‐dren w ho received a cochlear implant betw een 0 .9 and 3 .0 years old .

OBJECTIVE To compare the outcome measurement scores for hearing impaired people with hearing aids. Two kind of questionnaires of Chinese version--COSI and IOI-HA were developed in order to find out the more specific outcome measurements for hearing aid users in China. METHODS The COSI and IOI-HA were administered for 30 hearing aid users via telephone or by clinical interview. SPSS software was used to analyze the collecting data. RESULTS Five prevalent problems to which most of the people with hearing aids pay attention were summarized. The mean level of the satisfaction of all the participants was high. CONCLUSION The outcome measurement inventory reflects the major problems which patients concern most and it can be used to evaluate the aural intervention and rehabilitation. After further study, this method is worth extending clinical application.

OBJECTIVE: To analyze the characteristics and development of auditory skill for infants with different age before and after cochlear implantation by using infant-toddler meaningful auditory integration scale (IT-MAIS) questionnaire, and provide the useful information for the criteria of candidacy for cochlear implantation in infants and habilitation after cochlear implantation. METHOD: One hundred and thirty-nine prelingually infants with profound hearing loss were included in this study. According to the age at implantation, the infants were divided into 5 groups. They were group A ( < or =12 months), B (13-18 months), C (19-24 months), D (25-30 months) and E (31-36 months). Audiologists who were trained before this study used the IT-MAIS questionnaire to evaluate the auditory skill for all the infants and asked for the parents' or guardians' answers face to face. All the information about the infants spontaneous auditory behavioural responses was recorded in detail. The evaluation was performed before operation and 1 month, 3 months, 6 months, 12 months after switch-on. RESULT: There were no significant differences in mean scores over time between different gender who received cochlear implants by Independent-Samples T Test (P > 0.05). There were no significant differences in mean scores over time among the 5 groups by Multiple Comparison in ANOVA (P > 0.05). The scores were increased with time and there were significant differences in mean scores among the different time before and after switch-on by Multiple Comparison in ANOVA (P < 0.05) for each group. CONCLUSION The development of the auditory skill for infants followed the same rate in different gender. The auditory skill for infants after cochlear implantation developed rapidly regardless of age at implantation. Most of infants indicated rapid improvement in auditory skill within the first 6 months after switch-on, and then showed relative slow increase in the following 6 months.
Age Distribution ; Auditory Perception ; Child, Preschool ; Cochlear Implantation ; Cochlear Implants ; Female ; Humans ; Infant ; Language Development ; Male ; Persons With Hearing Impairments ; rehabilitation ; Treatment Outcome

OBJECTIVE: To evaluate the auditory performance of infants with cochlear implants at the early stage after surgery, summarize the development of auditory ability, investigate the effect of age at cochlear implantation on auditory performance within the first year after surgery and provide a reference for their habilitation program. METHOD: A total of 272 infants with prelingually profound hearing loss participated in this study, ranging in age at cochlear implantation from 18 to 36 months. The mean age was 21 months with a standard deviation of 7 months. Infants with cochlear implants were divided into three groups according to their age at implantation. Infants in group A were implanted under 18 months of age. Infants in group B were implanted between 18 and 24 months of age. Infants in group C were implanted between 25 and 36 months of age. Categories of auditory performance (CAP) was used to evaluate the auditory performance, which rates auditory abilities in eight categories for a scale of 0 to 7. RESULT: The mean scores of CAP for all infants at each interval were significantly different after implantation. Significant differences were observed in mean scores of CAP among these three groups in 1 and 3 months after switch-on. However there were no significant differences in pre-operation, 6, 9 and 12 months after switch-on. CONCLUSION There is a significant improvement in auditory performance of infants with prelingually profound hearing loss within the first year after cochlear implantation. The age at cochlear implantation has no critical influence on the development of auditory capabilities at the early stage after surgery. CAP is a practical tool which can be used in clinic in China.
Age Factors ; Child, Preschool ; Cochlear Implantation ; Cochlear Implants ; Deafness ; surgery ; Female ; Hearing ; Humans ; Infant

OBJECTIVE: A current technology for detecting and controlling transient noise in hearing aids (AntiShock) was evaluated. The objective was to evaluate AntiShock on loudness control and whether results in negative changes in sound quality of speech, transient noise and environmental noise and provide implications for hearing aid fitting. METHOD: Twenty-four subjects with sensorineural hearing loss participated in the study. In a single-blinded paradigm, the subjects were asked to rate loudness of transient noise and distortion of speech, transient noise and environmental noise with the AntiShock in both on and off conditions. RESULT: (1) The percentage of the transient noise rated as soft, comfortable, loud, too loud was 3.0%, 72.7%, 22.9% and 1.4%, respectively. There were significant differences in mean scores of loudness perception among listening conditions and between genders by a Two-Way ANOVA, the P values were 0.009 and 0.001, respectively. (2) The percentage of the speech rated as mild distorted, understandable, clear and very clear was 2.5%, 30.6%, 32.9% and 34.0%, respectively. There were significant differences in mean scores of speech distortion under different listening conditions by an One-Way ANOVA (P < 0.01). (3) The percentage of the transient noise rated as mild distorted, clear and natural was 2.9% and 97.1%, respectively. No significant differences in mean scores of nature of transient noise was found under different listening conditions by an One-Way ANOVA (P > 0.05). (4) The percentage of the environmental noise rated as mild distorted, clear but soft, clear and natural was 0.4%, 0.8% and 98.8%, respectively. No significant differences in mean scores of nature of environmental noise was found between different listening conditions by an Independent-Samples T Test (P > 0.05). CONCLUSION AntiShock showed positive effects on the loudness control of the transient noise. Quality of speech, transient noise and environmental noise were not impacted by AntiShock.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Equipment Design ; Female ; Hearing Aids ; Hearing Loss, Sensorineural ; rehabilitation ; Humans ; Loudness Perception ; Male ; Middle Aged ; Noise ; Quality Control ; Single-Blind Method ; Young Adult