1.De novo digestive system malignancy after liver transplantation
Zhijun ZHANG ; Haigang ZHONG ; Wei ZHANG ; Mangli ZHANG ; Weilin WANG ; Shusen ZHENG
Chinese Journal of Organ Transplantation 2016;37(9):513-517
Objective To investigate the clinical features and prognosis of patients with de novo digestive system malignancy after liver transplantation.Methods The clinical data of 10 patients with de novo digestive system malignancy out of 1 517 patients undergoing liver transplantation from January 2004 to December 2015 in the First Affiliated Hospital of Zhejiang University were collected.Immunosuppressive agents,type of de novo malignancy,process of treatment and prognosis were analyzed retrospectively.Results The incidence of de novo digestive system malignancy after liver transplantation was 0.7% (10/1 517),including 3 cases of gastric cancer,3 cases of colon cancer,2 cases of liver cancer,2 cases of pancreatic cancer.All of the 10 patients received the corresponding treatment,and the dosage of immunosuppressive agents was reduced at the same time.The median time from liver transplantation to the diagnosis of de novo malignancy was 40.5 months (23 to 156 months).The median follow-up time was 10.5 months (3 to 61 months) after they had been diagnosed as malignancies,and 6 patients died of tumor progression.Conclusions The prognosis of patients with de novo digestive system malignancy after liver transplantation is poor,and early diagnosis and treatment is an important way to improve prognosis.Liver transplant recipients need to be closely followed up,especially in patients with high risk factors of digestive system malignancy.The modification of immunosuppressive drugs may be an effective way to prevent and improve prognosis.
2. Analysis on key points for construction of trauma emergency center of Jiangxi Province
Yuanlin ZENG ; Haiming CHEN ; Lisheng LUO ; Xianlai XU ; Haigang XU ; Zhili LIU ; Sheng LIU ; Bin FU ; Xuefeng HUANG ; Zhongping YUAN ; Lidong WU ; Yuhua WAN ; Youjia TANG ; Chunming HUANG ; Peng RAO ; Hongfa ZHONG ; Bohe LI ; Yongan ZHANG ; Jiahua TANG ; Bo YOU
Chinese Journal of Trauma 2019;35(12):1126-1129
Trauma is the leading cause of death for people under 40 years old in the world. At present, the rescue and treatment system of trauma patients in China is not yet well established, and the mortality of trauma patients is higher than those in the developed countries. Improving the treatment system is the key to reducing the trauma mortality. In order to innovate the service mode of trauma first aid, further promote the establishment of regional trauma first aid system, improve the ability of trauma treatment, reduce the mortality and disability rate of trauma patients in Jiangxi Province, recently Health Commission of Jiangxi Province and the First Affiliated Hospital of Nanchang University have reached a consensus on the establishment of Jiangxi trauma first aid center. In order to provide reference for the construction of trauma treatment system, the author analyzes the following aspects including functional positioning, basic requirements, organization management, and evaluation of core indicators.