Objective To determine the curative effect of a trigeminy treatment including gen-tamycin, albumin and local oxygen therapy on treatment of ulcerative bedsore. Methods 50 cases of hospitalized patients in our hospital with ulcerative bedsore during January,2005 to December,2007 were selected. The patients were randomly classified into the experimental group and the control group with 25 patients in each group. The patients in the experimental group were treated by trigeminy treat-ment after debridement, while the patients in the control group were treated by covering with gen-tamycin and bandaging with dressing after debridement.The therapeutic effect of the two groups was compared by χ2 test. Results After the treatment, 6, 10, 6 and 3 patients in the experimental group, were healing, excellence, utility and inefficacy, respectively. On the contrast in the patients of the con-trol group, 2, 8, 5 and 10 were judged as healing, excellence, utility and inefficacy, respectively. The experimental group showed better effect than the control group. Conclusions The trigeminy treat-ment is able to remarkably increase clinical treatment effect of ulcerative bedsore.