Objective To investigate the incidence and trend of colorectal cancer in Wenling City of zhejiang Province from 2006 to 2011.Methods The date of colorectal cancer cases were collected from the tumor registersystem.The incidence rates,time trend and regional distributionof colorectal cancer were analyzed.Results The overall incidence of colorectal cancer in Wenling City was rising.The annual average incidence was 22.67/105.The incidence of colorectal cancer both in man and woman were increased with age,especially in ages between 55 and 75.The incidence of colorectal cancer was highest in city,followed in fringe area and lowest in rural.But the average annual growth rate was highest in rural.Conclusion The incidence trend of colorectal cancer is rising in Wenling City.Control measures of colorectal cancer according to the risk factors should be given,especially in rural area.

OBJECTIVETo investigate the effect of neutrophil gelatinase-associated lipocalin (NGAL) on prognosis of patients with type 2 hepatorenal syndrome (HRS).

METHODSA total of 54 patients with type 2 HRS were included in the study, and stratified for analysis according to survival status at 6-month followup:survival group, n=25; death group, n=29. Single factor analysis was used to compare the betweengroup differences for levels of plasma NGAL, urine NGAL, renin, aldosterone, and blood biochemical indicators. The Cox proportional hazard regression model was used to assess the prognosis of patients with type 2 HRS. The F-test, t-test, chi-square test, Pearson's correlation analysis, and Cox regression model were used for the statistical analyses.

RESULTSThe HRS patients with liver cirrhosis showed significantly lower levels of hemoglobin, platelets and albumin (all P < 0.05), but significantly higher international normalized ratio and levels of aspartate aminotransferase, alanine arninotransferase, total bilirubin, direct bilirubin, serum creatinine, plasma NGAL, urine NGAL, renin and aldosterone (all P < 0.05). Plasma NGAL and urine NGAL were positively correlated with renin, aldosterone, blood creatinine, MELD score, Child-Pugh score and ascites (P < 0.05). The patients in the 6-month survival group showed significantly lower levels of albumin, serum sodium, serum creatinine, plasma NGAL, urine NGAL, renin, and aldosterone than those in the death group (P < 0.05), but significantly higher glomerular filtration rate (vs. death group, P < 0.05). The Cox proportional hazard regression model showed that MELD, plasma NGAL, total bilirubin and creatinine were influencing factors of 6-month prognosis for patients with type 2 HRS (relative risk: 1.214, 1.157, 1.098 and 1.016 respectively).

CONCLUSIONPlasma NGAL is high in patients with type 2 FHRS, and is associated with risk of death.

Acute-Phase Proteins ; Bilirubin ; Biomarkers ; Creatinine ; Gelatinases ; Glomerular Filtration Rate ; Hepatorenal Syndrome ; Humans ; Kidney Function Tests ; Lipocalin-2 ; Lipocalins ; Liver Cirrhosis ; Neutrophils ; Prognosis ; Proportional Hazards Models ; Proto-Oncogene Proteins