1.Chaishao chengqi decoction and mirabilite in the treatment of severe acute pancreatitis
Chinese Journal of Pancreatology 2009;9(1):34-36
Objective To investigate the effect of chaishao chengqi decoction and mirabilite synthesis treatment for patients of severe acute panereatitis (SAP). Methods 62 cases of SAP were randomly divided into treatment group (n = 32) and control group (n = 30). Conventional treatment was administrated to control group, while chaishao chengqi decoction and mirabilite were added to treatment group. The duration of abdominal pain, the time of the first bowel, days of gastrointestinal decompression, average days of hospitalization, hyperamylasemia, complication and mortality was compared. Results The duration of abdominal pain, the time of the first bowel, days of gastrointestinal decompression, average days of hospitalization and complication rate were (5.8 ± 2.5) d, (1.84 ± 0. 67) d, (8.2 ± 2.2) d, (21.2 ± 12.5) d and 15.6% in treatment group,respectively, which were lower than those in the control group (P <0.05). Duration of hyperamylasemia (10.2 ± 3.2d) and mortality rate (3.12%) in treatment group was lower than those in the control group without statistic difference (P > 0. 05). Coucluslons Based on conventional therapy, chaishao chengqi Decoction and mirabilite could improve gastrointestinal function of SAP, shorten course of disease, reduce the occurrence of complication and improve the prognosis.
2.Risk factors for cardiovascular complications in the elderly patients with dialysis
Wei JIANG ; Xuezhu LI ; Haidong YAN
Chinese Journal of General Practitioners 2008;7(1):22-25
Objective To investigate the risk factors for cardiovascular complications in the elderly persons undergone with dialysis.Methods One hundred and eighteen patients undergone with hemodialysis(HD)or continuous ambulatory peritoneal dialysis(CAPD)at the Eastern Hospital, Tongji University, Shanghai during January 2002 to December 2006 were retrospectively analyzed.They were divided into four groups based oil their age and mode of dialysis, i.e., 44 patients in the elderly HD group(aged over 60years), 16 patients in the elderly CAPD group(aged over 60), 46 patients in medium-age HD group(aged under 60 years)and 12 patients in the medium-age CAPD group(aged under 60).Routine biochemical parameters were measured for all the patients and their difference was compared among the four groups.Logistic regression analysis was performed for the risk factors of cardiovascular complications.Results Pulse pressure(PP)was(66±21)mm Hg, serum level of triglycerides(TG)was(1.28±0.67)mmol/L, serum level of lipoprotein(a)[LP(a)]was(434±202)mg/L, C-reactive protein was(CRP)(21±15)mg/L, serum phosphorous(P3-)was(2.02±0.77)mmol/L, and product of serum calcium and phosphorous(Ca×P)was(4.3±1.6)mmol2/L2, respectively, in the elderly group with dialysis, all significantly higher than those in the medium-age group with dialysis(t=1.535, 1.016, 2.154, 2.252, 4.676, and 4.534, respectively, P<0.05).Incidence of cardiovascular events was markedly lower in the CAPD group than that in the HD group(P<0.05), either in the elderly or medium-aged patients.And, incidence of cardiovascular complications correlated positively with age, PP, LP(a), CRP and Ca×P of the patients with dialysis, but correlated reversely with serum level of albumin(all with P<0.05).Conclusions There exist a few risk factors for cardiovascular complications in the elderly patients with dialysis, so proper mode of dialysis should be selected for those who need it and adequate intervention should be implemented for them to correct the risk factors.
3.The diagnosis and treatment for major arterial injuries of the extremities
Wei WANG ; Changping XIE ; Haidong HUANG ;
Chinese Journal of Orthopaedic Trauma 2002;0(03):-
Objective To investigate the diagnosis and treatment of major arterial injuries of the extremities. Methods In the period between September 1999 and June 2002, 129 patients with 176 arterial injuries were admitted to our hospital. 122 patients of them with 162 arterial injuries underwent microsurgical repair. Results The limbs of 116 patients with 154 arterial injuries survived. The total survival rate of affected extremities was 89.9% ; the blood vessel recanalization rate was 95.06% . Conclusion Careful physical examination and advanced vascular Doppler equipment can avoid missed diagnosis, and microsurgical technique in vascular repair can successfully save limbs.
4.MicroRNAs with the Regeneration and Differentiation of Islet β cells and the Targeted Therapy of Traditional Chinese Medicine
Xinying LI ; Haidong GUAN ; Wei WANG
World Science and Technology-Modernization of Traditional Chinese Medicine 2016;18(7):1188-1194
MicroRNAs (miRNAs) are a class of non-coding RNAs about 18-25 nucleotides in length,involved in post-transcriptional genes regulation process.Previous studies showed that miRNAs played an important regulatory role in pancreatic development,gene expression,and synthesis and secretion of insulin.A variety of miRNAs which expressed in islet β cells may affect the proliferation and differentiation of islet β cells.Since miRNAs showed tissue specificity,their expression changes were closely related to some diseases.Thus,integrative studies with miRNAs over the essence of syndromes of traditional Chinese medicine could provide new ideas for the treatment of diabetes.
5.Effect of potassium magnesium aspartate on arrhythmia and heart function in valve replacement postoperative patients of rheumatic heart disease
Wei WANG ; Wei WU ; Ping HE ; Haidong WANG ; Kang YANG
Journal of Third Military Medical University 2003;0(23):-
Objective To evaluate the curative effect of potassium magnesium aspartate on arrhythmia and heart function in valve replacement postoperative patients of rheumatic heart disease. Methods Two hundred and eighty patients with rheumatic heart disease were divided into 2 groups in random,with no statistical significance. Treatment group (n=155) were received i.v. potassium magnesium aspartate 40 ml every day and control group (n=125) were only given conventional therapy. At the same time they were given same treatment. Blood magnesium level,blood potassium levels,arrhythmia incidences and heart function were also observed. Results Blood magnesium and potassium levels of the treatment group were higher than those of the control group (P
6.Clinical studies of immunofunction and protein metabolism by combined supplementation of glutamine and recombinant human growth hormone in postoperative patients with cardiogenic cachexia of rheumatic heart disease
Wei WANG ; Wei WU ; Ping HE ; Haidong WANG ; Kang YANG
Journal of Endocrine Surgery 2009;3(2):116-119
Objective To study the effects of recombinant human growth hormone(rhGH) on the treatment for valve replacement postoperative in rheumatic heart disease associated cardiac eaehex.Methods Fortytwo patients with rheumatic heart disease associated cardiac eachexia were divided into two groups.Group one(n=20,rhGH group) received standard enteral nutrition (15 kal·kg-1 · d-1)with rhGH 10U injection subeutaneously from postoperation day 7 to day 14 and group two(n = 22,eontrol group) received standard enteral nutrition (15 kal·kg-1· d-1) for the same period.Haemoglobin, serum total protein, serum albumin, blood glucose, handgrip exercise and triceps skin_fold thickness were determined.Meehanieal ventilation, hypostatie pneumonia incidence rate, and length of stay were observed.Results The levels of serum total protein, serum albumin and blood glucose eoneentration in the rhGH group at the 14th day were inereased significantly compared to that in the control group(P <0.01).Haemoglobin, triceps skinfold thiekness and handgrip exercise in rhGH group were significantly different from those in the control group(P <0.05).Postoperative meehanieal ventilation time, intensive care unit time, hospital stay time were signifieantly shorter than those in the eontrol group (P < 0.05), and hypostatie pneumonia was significantly lower than that in the eontroi group(P < 0.01).Conclusions The rhGH can obviously improve anabolie effects of patients with rheumatic heart disease associated cardiac eachexia whieh can reduce hypostatie pneumonia and shorten postoperative hospital stay time.
7.Clinical study of facial nerve dissection approaches in parotidectomy
Xu YAN ; Yan PENG ; Haidong WEI ; Bo PENG ; Dawei MI
Journal of Practical Stomatology 2016;32(1):129-131
40 cases of parotidectomy were reviewed.Anterograde approach(group A)and retrograde approach(group B)for facial nerve dissection were used in 1 7 and 23 cases respectively.1 patients in group A and 8 in group B presented symptoms of temporary facial nerve paralysis(P <0.05).The anterograde method is safer and quicker.
8.Finite element analysis of stress of the adjacent vertebral end plate of T12vertebral body in different compression states
Jierong FENG ; Haidong YIN ; Wei CHEN ; Mingguang HUANG
Chinese Journal of Tissue Engineering Research 2016;20(22):3263-3271
BACKGROUND:Vertebral compression fractures are the most common vertebral fractures in the elderly patients with osteoporosis, and the correlation between the compression of anterior border of vertebral body and adjacent vertebral refractures is not clear.
OBJECTIVE:To establish a model of different compression of T12vertebral body with finite element method, and analyze the relationship between the compression of T12vertebral body and the stress of adjacent vertebral plate.
METHODS:Based on thoracolumbar CT data of normal adult volunteers, MIMICS/3-matic was imported. Through image segmentation, repair and three-dimensional mesh of accessto thoracic and lumbar T11-L1data, grid assigned material properties was imported to ABAQUS so as to establish ligament, joint and other small features and obtain realistic three-dimensional finite element model. The six degrees of freedom, including anteflexion, posterior extension, left and right flexion, left and right rotation, were loaded, to verify the validity of the normal model. With the frontier of vertebral body compression to 90%, 80%, 70%…10% of the nine states, MISES stressesof the T11andL1segment intervertebral disc endplate were extracted; the relationship curve of compression state and endplate stress was obtained.
RESULTS AND CONCLUSION:(1) The model was highly realistic and could reflect the actual stress state. (2) The stress value of T11vertebral body and L1vertebral body was positively correlated with the compression of T12vertebral body. Increased stress may lead to an increased likelihood of end plate fractures, which increases the risk of fractures in the adjacent vertebralbodies.
9.Semaphorin familily and glioma
Haidong ZHANG ; Wei ZHANG ; Hui WANG ; Guangting ZHU
Journal of International Oncology 2016;43(4):299-301
Semaphorins act as axon guidance molecules,which were either secretory or binding to the cell surface.All its family members contain a Sema structure,which is composed of about 500 amino acid residues and is essential for its biological activity.Functionally,they play different roles in tumors,such as oncogenes or tumor suppressor genes,and their abnormal expressions are related to the proliferation,migration and invasion of glioma cells.Semaphorins may be the therapeutic targets for the clinical treatment of glioma.
10.Correlation Study on Iron Content, Yield and Quality ofCornus ofifcinalis
Yuping XIONG ; Chengming DONG ; Wei XIA ; Zhenhui DU ; Haidong YE
World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(5):1022-1024
This article was aimed to study the correlation between iron content inCornus officinalis leaves and its yield as well as quality. The method of microwave digestion atomic absorption spectrophotometer was used to determine the content of iron element inCornus officinalis leaves. HPLC was used to determine the content of loganin and ursolic acid in fruits. Correlation analysis was made among the content of iron element, yield of fruits, loganin and ursolic acid in fruits. The results showed that iron element in leaves of different yield level cornus officinalis was different. It also had some correlation with yield and quality of fruits. It was concluded that the research can improve relations of source-sink inCornus ofifcinalis, adjust source-sink balance, guide farmers to master the period of spraying iron fertilizer, and increase production and quality ofCornus ofifcinalis.