Objective To discuss Magnetic Resonance Spectroscopy(MRS) on the localization diagnosis of primary epilepsy patients with hippocampal lesions before operation.Methods 50 patients with idiopathic epilepsy (epilepsy group) and 32 healthy volunteers (healthy control group) were underwent Magnetic Resonance Imaging ( MRI) and MRS examination.Results ( 1 ) MRI showed that results of examination in the healthy control group were all normal.Epilepsy group of 38 cases were found abnormal in hippocampal area,and all patients were unilateral. 27 cases of them reduced with hippocampal volume, while signal abnormality was in 7 cases, 4 cases occurred simultaneously reduced with hippocampal volume,and therer was no obvious abnormal signals in 12 cases of patients with epilepsy of hippocampus volume and signal.( 2 ) MRS examination results:the healthy control group MRS were normal.50 epileptic patients in group MRS showed that hippocampal abnormalities.The epilepsy group NAA/( Cho+Cr) ,NAA/Cho,NAA/Cr were significantly lower than those of the healthy control group;epilepsy group disease side hippocampus NAA/(Cho+Cr),NAA/Cho,NAA/Cr values have different degrees of reduction,compared with the contralateral side,the value of t were 12.716,9.155,17.476,all P<0.01.(3)50 cases of epilepsy patients in the epilepsy group disease side compared with the contralateral side,the side of hippocampus NAA/disease ( Cho+Cr) , NAA/Cho,NAA/Cr values were decreased,the test values of t were 7.295,6.303,2.761,all P<0.01.(4)50 cases of operation patients underwent postoperative pathological examination of resected tissue,resection of neurons,tissue showed different degrees of reduction,microglia proliferation and neuronophagia phenomenon.Comparison of the posi-tive rate of MRS and MRI examination,χ2 =13.636,P<0.01.Conclusion Magnetic resonance spectroscopy analy-sis can play the important role in the evaluation of epilepsy surgery preoperative epilepsy,MRS examination for preop-erative diagnosis positive rate is high,the localization diagnosis with high reliability.

Objective:To compare the effects of non-invasive bi-level pressure triggering (BiPhasic tr) on oxygenation index (OI), partial pressure of oxygen and utilization rate of mechanical ventilation in premature infants with respiratory distress syndrome (RDS).Methods:The clinical data of 100 premature infants with RDS in Shantou Dafeng Hospital of Guangdong Province from March 2018 to May 2019 were retrospectively analyzed. Among them, 56 cases treated with nasal continuous positive airway pressure (nCPAP) were enrolled as control group, and 44 cases treated with BiPhasic tr were as observation group. The OI, arterial partial pressure of oxygen (PaO 2) and arterial partial pressure of carbon dioxide (PaCO 2) before and after respiratory support, duration of auxiliary ventilation, utilization rate of mechanical ventilation and incidence of complication were compared between 2 groups. Results:There were no statistical difference in PaO 2, PaCO 2 and OI before respiratory support between 2 groups ( P>0.05); the PaO 2, PaCO 2 and OI 1, 6, 12 and 24 h after respiratory support in 2 groups were significantly improved compared with those before respiratory support, and the improvement degree in observation group were significantly better than those in control group, and there were statistical differences ( P<0.05). The duration of auxiliary ventilation, utilization rate of mechanical ventilation, incidence of complication in observation group were significantly lower than those in control group: (52.41 ± 16.53) h vs. (57.42 ± 17.82) h, 11.36% (5/44) vs. 19.64% (11/56) and 15.91% (7/44) vs. 33.93% (19/56), and there were statistical differences ( P<0.05). Conclusions:BiPhasic tr can effectively improve the oxygenation state, reduce the use rate of mechanical ventilation and carbon dioxide retention, reduce the incidence of complications such as intraventricular hemorrhage and so on in the treatment of RDS premature infants.