1.A Study on the Construction of the Open Optional Courses of Medicine in Universities
Yuzhuang HUANG ; Hongmei CHEN ; Zhiquan BAI
Chinese Journal of Medical Education Research 2005;0(06):-
Strengthening the construction of open optional courses of medicine in universities is necessary for us to make good use of the teaching resources,to optimize the open optional courses system,and to improve the quality education.This thesis analyzes the problems of open optional courses of medicine in the university by questionnaire.It brings out ways to further improve the construction of open optional courses of medicine in universities.
2.A Study on the Construction of Hidden Curriculum in Colleges and Universities
Yuzhuang HUANG ; Zhiquan BO ; Hongmei CHEN
Chinese Journal of Medical Education Research 2006;0(09):-
The research of curriculum tells us that in every university there are two kinds of curriculums.One is noticeable,the other is hidden.Both of them work for the goal of bringing the students up.The witchery of hidden curriculum is that it affects the students continually and secretly.This essay discuses the significance,principle and approaches of the construction of hidden curriculum in higher learning.
3.MRTF-A mediates FN and ICAM-1expressions by NF-κB pathway in AGEs-induced GMCs.
Qiuhong CHEN ; Zhiquan CHEN ; Jiani HUANG ; Heqing HUANG
Chinese Pharmacological Bulletin 2017;33(4):572-577
Aim To observe the expression of MRTF-A in rat glomerular mesangial cells(GMCs) induced by advanced glycation end products(AGEs) and its effect on ICAM-1 and FN;to explore whether MRTF-A is involved in the process of diabetic nephropathy by affecting NF-κB pathway.Methods Under the condition of AGEs, CCG-1423 and anti-MRTF-A small interfering RNA were used to knock down MRTF-A and MRTF-A plasmid was used to activatt MRTF-A, The expression level of MRTF-A, ICAM-1, FN and p65 in nucleus were detected by Western blot.Results The protein expressions of MRTF-A was increased in AGEs-induced GMCs.The expressions of FN and ICAM-1 and p65 in nucleus were downregulated by knocking down MRTF-A.However, the expressions of FN, ICAM-1 and p65 in nucleus were upregulated by overexpressing MRTF-A.Conclusions AGEs can upregulate the expression of MRTF-A in GMCs, and MRTF-A mediates the protein expressions of FN and ICAM-1 by affecting NF-κB signaling pathway in AGEs-induced GMCs.
4.The correlation between postural hypotension and myocardial infarction in the elderly population
Zhongqiu LIN ; Chunmei PAN ; Weihua LI ; Keqiang HUANG ; Zhiquan XIE
Chinese Journal of Internal Medicine 2012;51(7):520-523
Objective To investigate the association between the systolic/diastolic orthostatic hypotension (OH-S/OH-D) and myoeardial infarction (MI) in the elderly.Methods Health screening physical examination were carried in 1081 subjects without MI aged over 65 years in Guangzhou Military region.The orthostatic blood pressure and heart rate were measured in supine position after resting for more than 5 minutes and at 0 and 2 minutes after standing.All the cases were divided into systolic or diastolic group on the basis of definition of orthostatic hypotension and followed up by telephone or inpatient medical records with mean period of 315.8 days.The primary endpoint was MI occurrence.Results The prevalence of OH in this cohort was 24.5% ( OH-S/OH-D:19.3%/17.2% ).Significant differences in the occurrence of OH and OH-S were found in the elderly and the very elderly subjects( ≥80 years) (26.1% vs 20.1%,P=0.045; 21.0% vs 14.6%,P =0.018),while no difference was found in OH-D.The prevalence of MI in the OH positive subjects was significantly higher than that in the OH negative subjects,as well as in OH-S or OH-D group.After adjustment of age,supine blood pressure,creatinine and cerebrovascular history by logistic regression,the association was observed between MI and OH ( HR 15.635,95 % CI 3.299-74.091,P=0.001),OH-S(HR 8.760,95%CI2.487-30.851,P=0.001)and OH-D(HR 3.889,95% CI 1.097-13.790,P =0.035 ).Conclusion OH-S and OH-D hypotension are robust predictors for MI in the elderly.
5.On the Practice of the Minimum Requirements of Global Medical Education
Zhiquan BAI ; Yuzhuang HUANG ; Liping CHEN ; Jiuxiang LI ; Jienan AO
Chinese Journal of Medical Education Research 2006;0(09):-
Global minimum essential requirements in medical education(GMER) was established by the Institute for Intemational Medical Education(IIME),which consisted of members from all over the world,the GMER should be reached by all of the graduates.This paper analyzes the importance and possibilities that the university of the extrovert type ushers in the international medical education standard,and according to actual work,put forward some suggestions.
6.The efficacy of calcined natural bovine bone(CBB)in the treatment of bone defects in animal
Yue HE ; Zhiquan TIAN ; Liang WANG ; Yang YAO ; Lu YANG ; Wentao HUANG ; Xinhui HUANG
Journal of Practical Stomatology 2015;(2):167-170
Objective:To observe the efficacy of calcined bovine bone(CBB)in the repair of animal bone defects.Methods:Ca-nine alveolar bone defect model,rat and rabbit calvarial critical size defect models were established respectively.All animals were randomly divided into 2 groups(n=6).The defects in the experimental group were repaire with CBB,those in the control group were not treated.The effects were observed by HE staining,Micro CT and Masson trichrome staining.Results:Canin alveolar bone de-fects were well repaired 8 week after operation.The skull defects in rabbits and SD rats were replaced by new bone 1 2 and 8 weeks after operation respectively.In all the control groups bone defects were not healed or not completely repaired.Conclusion:CBB is ef-fective in the repair of bone defects.
7.Ischemic preconditioning induced functional opening of myocardial capillary beds
Zhiquan XIE ; Yili LIU ; Daogang ZHA ; Cuiyao HUANG ; Dongfang QIAO ; Yanlie ZHENG ; Yuanhui ZHANG ; Pingshen WU
Chinese Journal of Pathophysiology 1989;0(05):-
AIM:To explore the protective effect of ischemic preconditioning on myocardial capillary bed. METHODS: Anesthetized open-chest dogs in ischemic preconditioning (IP) group ( n =6) were subjected to 5 min ischemia and 5 min reperfusion for 4 times in left descending coronary artery (LDA) while the dogs in sham-operated (SO) group ( n =6) were observed for 40 min without any stimulating. Myocardial contrast echocardiography (MCE) was performed before the surgery, at the end of the first and the fourth ischemia and reperfusion period, respectively. Myocardial samples in ischemic area were obtained for capillaries ultrastructure examination and their quantitative analysis was conducted by corresponding imagine analyzing system, then compared within group and between control group. RESULTS: (1) Comparing fourth 5 min ischemia with first one, the percents of area defect in minimum (AD min%) by MCE decreased from 32.6%?5.7% to 21.8%?5.2%( P
8.Preventive chemotherapy for hepatocellular carcinoma exceeding Milan criteria after fiver transplantation
Zheng WANG ; Jia FAN ; Jian ZHOU ; Zhiquan WU ; Shuangjian QIU ; Xiaowu HUANG ; Yao YU ; Jian SUN
Chinese Journal of Digestive Surgery 2008;7(4):268-270
Objective To investigate the effects of preventive chemotherapy for hepatocellular carcinoma (HCC) exceeding Milan criteria after liver transplantation. Methods The clinical data of 243 patients who had undergone orthotopic liver transplantation for HCC exceeding Milan criteria from April 2001 to July 2007 were retrospectively analyzed. Of all patients, 162 received preventive chemotherapy after transplantation. Results The 1- and 3-year survival rates and disease-free survival rates were not statistically different between patients who had received chemotherapy (78.5%, 63.7% ; 76.8%, 52.5% ) and those without chemotherapy (56.6%, 39.1%; 69.3%, 64.7% ) (X2 = 3.084, 0.444, P > 0.05). Cox regression analysis demonstrated that postoperative chemotherapy was not an independent factor affecting the survival rates of HCC patients without vascular invasion, but an independent factor affecting the survival rates of HCC patients with vascular invasion. Conclusions Early preventive chemotherapy could obviously increase the survival rate and delay the tumor recurrence of patients with HCC exceeding Milan criteria, especially for HCC patients with vascular invasion.
9.Salvage liver transplantation for postoperative tumor recurrence or liver dysfunction in patients of hepatocellular carcinoma
Guohuan YANG ; Jia FAN ; Jian ZHOU ; Zhiquan WU ; Shuangjian QIU ; Xiaowu HUANG ; Yuqi WANG
Chinese Journal of General Surgery 2008;23(7):484-486
Objective To evaluate salvage liver transplantation(LT)for postoperative tumor recurrence or liver dysfunction in patients of hepatocellular carcinoma(HCC).Methods From April 2001 to March 2006,97 HCC patients with the tumor within Milan Criteria underwent LT as the primary treatment(71 cases)and salvage LT because of after resection tumor recurrence(n=20)or postoperative liver dysfunction(n=6).Perioperative and postoperative parameters and long-term survival were compared between the groups of primary LT and salvage LT.Results The mean age(50.0 years vs.49.7 years),gender,and etiology of liver disease(hepatitis B/C/nonviral)were comparable between the two groups.In the salvage LT group.the mean time between liver resection and LT was 2.50 years.Clinical characteristics such as tumor number(1.37 vs.1.50),operative time(7.92 hours vs.8.56 hours),blood loss (1981.69 ml vs.2626.92 ml)and transfusion(1981.69 ml vs.2626.92 ml)were not statistically different (P>0.05)between the two groups.The size of largest tumor was significantly different between salvage LT group and the primary LT group(2.81 cm vs.2.05 cm)(t=2.298,P=0.028).By a median follow up of 14.63 months,overall survival after liver transplantation was not different between the 2 groups(X2=0.003.P=0.959).Conclusion In selected patients,liver resection prior to transplantation does not increase the morbidity or impair long.term survival following LT.Therefore.1iver resection prior to transplantation can be integrated with the treatment strategy for HCC.
10.Dianosis and treatment of hepatic metastasis from gastrointestinal stromal tumor
Yinghao SHEN ; Jia FAN ; Zhiquan WU ; Jian ZHOU ; Shuangjian QIU ; Yingyong HOU ; Yao YU ; Xiaowu HUANG
Chinese Journal of Digestive Surgery 2008;7(6):450-451
Objective To investigate the diagnosis and treatment of hepatic metastasis from gastrointestinal stromal turnor(GIST).Methods The clinical data of 16 patients with GIST who had been admitted to our hospitalfrom December 1993 to May 2007 were retrospectively analyzed.Results Of all patients,14 underwent radical resection and 2 underwent palliative operation.Two patients with palliative operation and 3 with radical resection were administered with imatinib postoperatively. All patients were followed up for 3-161 months,and GIST metastasis and invasion was observed in 8 of the 14 patients who received radical resection.Of the 7 patients with hepatic metastasis.3 were treated with hepatic artery chemoembolization,1 was administered with imatinib,2 received reoperation and 1 did not receive any treatment. Reoperation was carried out on 1 patient who had abdominal wall metastasis.The 1-and 3-year survival rates of the 16 patients were 92%and 74%,respectively.Conclusions The recurrence rate of GIST after hepatectomy is high.Complete surgical resection is the best curative treatment for hepatic metastasis from GIST and GIST recurrence.The combination of surgical resection and imatinib administration may help to improve the prognosis of patients with hepatic metastasis from GIST.