1.Observation on effect of Glucosidorum Tripterygll Totorum on chronic glomerulonephritis
International Journal of Traditional Chinese Medicine 2010;32(4):312-313
Objective To approach effect of glucosidorum tripterygll totorum on chronic glomerulonephritis.Methods A total of 182 cases of chronic glomerulonephritis were randomly recruited into a treatment group (103 cases) and a control group (79 cases). The control group was treated with valsartan capsule, 80mg per time, once daily, and prednisone for those cases of intractable proteinuria, 1 mg/kg, once daily. The treatment group was treated with glucosidorum tripterygll totorum the basis of the control group. Therapeutic effects in both groups were evaluated. Results The total effective rate was 83.5% in treatment group and 65.8% in control group, showing significant difference (t=2.0134, P=0.0785) Conclusion Glucosidorum tripterygll totorum has sound therapeutic effects on chronic glomerular nephritis.
2.Clinical observation on treatment of 23 cases of chronic renal failure with herbal retention-enema
International Journal of Traditional Chinese Medicine 2010;32(6):513-514
Objective To observe the clinical effect of treating chronic renal failure with herbal retention-enema.Methods 23 cases with chronic renal failure were randomly recruited into a control group and a treatment group. The control group was treated with routine western medicine (low salt, low fat, and low protein diet, and correcting disturbance of water-electrolyte and acid-base balance), and the treatment group was treated with herbal retention-enema (Rhubarb, Concha ostreae, Dandelion, and Processing aconite). The clinical effect was observed in both groups. Results The clinical effect in the treatment group was significantly higher than that of the control group (χ2=3.456, P<0.05). Conclusion The treatment of chronic renal failure with herb retention-enema is better than routine western medicine.
3.Care of Preoperative Autologous Blood Donation in Late Pregnancy
Journal of Zhejiang Chinese Medical University 2014;(1):101-102,106
[Objective] To ensure the safety of preoperative autologous blood donation in late pregnancy through a series of nursing measures.[Methods]From January 2010 to November 2011, 52 cases of pregnant women in late pregnancy took storage autotransfusion. After prenatal guardianship, psychological care, health education, blood were col ected before and after care, custody and from the blood transfusion care; record blood col ection process pregnant women with maternal-fetal reaction, the vital signs of pregnant women, birth outcomes, since the amount of al ogeneic blood transfusion, and achieve satisfactory re-sults.[Results] 52 cases of pregnant women with the blood col ection process were good, normal, with stable vital signs, abnormal fetal heart rate monitoring, one case of fetal moved too much, given the oxygen, improved with the left lateral decubitus position. In the process of self-blood transfusion, there's no ma-ternal discomfort, but with safe motherhood. [Conclusion] Effective care measures and storage of a pregnant woman autologous transfusion are relatively safe, economical and effective in the transfusion way, achieve good results, and help to improve the quality of obstetric care.
4.Effects of Dipeptidyl Peptidase-4 inhibitor on albuminuria in patients with type 2 diabetes mellitus
Chinese Journal of Diabetes 2017;25(5):468-471
Dipeptidyl Peptidase-4 inhibitor (DPP-4 inhibitor),a new kind of oral anti-diabetic medicine,has been widely used for the treatment of type 2 diabetes (T2DM) during the last decades.Recent evidence showed that DPP-4 inhibitor may have renal protective effects beyond glycemic control.Some clinical studies revealed that the reduction of HbA1c by DPP-4 inhibitor was paralleled by an improvement of albuminuria and renal function.Experimental studies indicated that the renal protection mechanism of DPP-4 inhibitor may be involved in its multiple effects including anti-inflammatory,anti-oxidation and improvement of endothelial function.However,the evidence of decreasing albuminuria for DPP-4 inhibitor mainly comes from animal models and some clinical trials with small sample size.More large randomized controlled trials (RCT) will be needed to certify the renal protection effect of DPP-4 inhibitor.In this review,the role of DPP-4 inhibitor on albuminuria will be considered and discussed from both experimental and clinical perspectives.
5.Construction and identification of the recombinant eucaryotic plasmid PcDNA3.1-MxA
Journal of Chongqing Medical University 1986;0(02):-
Objective:To construct and identify the recombinant eukaryotic plasmid PcDNA3.1-MxA encoding MxA with the eukaryotic plasmid PcDNA3.1.Methods:Recombinant plasmid PAdTrack-MxA constructed before and PcDNA3.1 were amplified in Escherchia coli JM109.Plasmids were double-digested with restrictive endonucleases NotⅠ and XbaⅠ after extracted,and then ligated to construct recombinant eukaryotic plasmid PcDNA3.1-MxA.The recombinant plasmid was selected for Ampicillin resistance and then confirmed by digestion with NotⅠ and XbaⅠ,PCR and sequencing.The sequence was homology-analysed compared with the sequence of MxA gene in PAdTrack-MxA and the sequence of MxA gene published in Genebank(NM_002462) with sofeware DNAssist 2.0.Results:The restrictive endonuclease and PCR analysis confirmed that the recombinant eukaryotic plasmid PcDNA3.1-MxA was constructed successfully.Sequencing analysis revealed that the cloned segment was 2012bp including MxA gene sequence,and the nucleotide sequence of MxA gene was same to that in PAdTrack-MxA exactly.There were five variations in nucleotide sequence compared with published sequence in Genebank,which caused only one amino acid residue replaced from isoleucine to valine.This replaced amino acid residue was located in the non functional area of MxA protein.Conclusions:The recombinant eukaryotic plasmid PcDNA3.1-MxA is constructed successfully,which lays foundation for the further study on anti-HBV effects of MxA.
6.ULTRASTRUCTURAL CHANGES OF SKELETAL MUSCLE OF HINDLIMBS IN RATS DURING ISCHEMIA-REPERFUSION INJURY
Academic Journal of Second Military Medical University 1985;0(06):-
In this study, the ultrastructural changes of skeletal muscle of hindlimbs in rats were observed. Skeletal muscle of 5 h ischemia showed diminished glycogen granules, swelling of mitochondria, clearing of mitochondrial matrix, breakage of mitochondrial crista and dilatation of sarcoplasmic reticulum. Skeletal muscle of 5 h ischemia and 1/2 h or 12 h reperfusion showed high amplitude swelling of mitochondria with rupture of mitochondrial membrane, dense granules in mitochondrial matrix and complete loss of normal organization of myofibrils. The results demonstrate that reperfusion after prolonged ischemia exaggerates tissue injury.
7.Outcomes analysis for the family doctor contact system and outpatient coordination system in Qingdao
Chinese Journal of Hospital Administration 2013;(2):127-130
Objective To study outcomes of the family doctor contact system and outpatient coordination system in Qingdao.Methods Random selection of 400 community residents and 576 outpatients for a questionnaire survey,using t tests and time series analysis.The purpose is to analyze the number of insured workers,community referrals,costs of hospitalization and the proportion of out-of-pocket payment,and impacts on community healthcare services.Results Number of insured works increased year by year,up to 1,739,931 in 2010.The proportion of community referred hospitalization was raised to 56.97% in 2010 and increased 54.26% compared to 2007.Hospitalization costs and the proportion of out-of-pocket payment were reduced.Conclusion The family doctor contact system and outpatient coordination system in Qingdao proved a success,as the practices were highly popular among the employees,and benefited community health centers as well,making it worthwhile to promote.
8.Endovascular interventional therapy of carotid stenosis
International Journal of Cerebrovascular Diseases 2013;21(11):867-874
The incidence of carotid stenosis disease increases with age,and it is one of the major causes of ischemic stroke.In recent years,with the rapid development of endovascular treatment technology,the therapeutic means,including carotid angioplasty and stenting,has been widely carried out both at home and abroad.This article reviews the advances in endovascular treatment of carotid stenosis.
9.The importance of clinical data management in improvement of drug evaluation.
Acta Pharmaceutica Sinica 2015;50(11):1408-1409
Although the importance of clinical data is drawing more attention in drug development in China, the clinical data management is not good enough in the clinical trials right now. With the development of internet and progress of information technology, especially with the setup of the state innovation strategy for drug development, it is necessary and urgent to improve the clinical data quality. Good data quality is the primary basis of technical evaluation of drug at the marketing authorization. So Center for Drug Evaluation of CFDA has made some endeavors to enhance data management in the clinical trials in recent years. This article is focused on these aspects of data managment.
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10.The importance of clinical data management in improvement of drug evaluation.
Acta Pharmaceutica Sinica 2015;50(11):1408-9
Although the importance of clinical data is drawing more attention in drug development in China, the clinical data management is not good enough in the clinical trials right now. With the development of internet and progress of information technology, especially with the setup of the state innovation strategy for drug development, it is necessary and urgent to improve the clinical data quality. Good data quality is the primary basis of technical evaluation of drug at the marketing authorization. So Center for Drug Evaluation of CFDA has made some endeavors to enhance data management in the clinical trials in recent years. This article is focused on these aspects of data managment.