The production of IL-2 by peripheral blood lymphocytes from patients with Ankylosing Spondylitis (AS)and Rheumatoid Arthritis (RA) was compared with that of healthy controls. Patients with AS and RA showed a significant overproduction of IL-2.Membrane-bound IL-2 receptor was recognized by monoclonal anti-Tac antibody by using a flow cytometry. There was a marked increase of IL-2 receptor in patients with RA, while the level of IL-2 receptor in patients with AS was comparable to that of normal controls. The results suggested that there was obvious abnormalities of membrane-bound IL-2 receptor expressing and production of IL-2 in patients with AS and.RA which may contribute to the pathogenesis of these diseases.

Acquired immunodeficiency syndrome (AIDS) is a serious infectious disease caused by human immunodeficiency virus (HIV). Increasing cases of HIV infection have been detected in adolescents. Intravenous drug abuse and sexual behavior, which are affected by various individual and environmental factors, are the major ways of HIV infection. The current situation and influential factors of HIV infection in adolescents are introduced in this paper.

The important difference between post-graduate and undergraduate education is to train their reseach ability,which is very important especially to the post-graduate students of basic medicine who will be researchers.The problem in training research ability of post-graduate was studied in this paper and solution plan was put forward.

Currently,bone marrow derived mescenchymal stem cells(MSCs) are the best available cell population for tendon tissue engineering.Recent adipose-derived MSCs show characteristics of multipotentital and may be used as functional cells for tendon tissue engineering.Nanofiber scaffolds can mimic the structure and function of extracellular matrix,and have advantages for tendon tissue engineering.A variety of gene transfer techniques can be used to maintain local concentrations of growth factor at tendon repair site.Although tremendous progress has been achieved in the field of tendon tissue engineering,many challenges remain and much work still needs to be done.

砄bjective: To develop a computer aided cephalometric analysis system running under the environment of Windows 9X/NT and based on screen input of landmark and contour line. Methods: The analysis system was made with object oriented method, the program was written with Visual Basic 6.0 and Access 8.0, and the data on the screen was converted. Results: Cephalometric landmark points and contour lines were input through computer screen, then analyzed (22 modes), superposed and managed statistically. The system showed the advantages of using popular hardware, good compatibility, easy expansion, friendly user interface, simple input of landmark points, artful input of cephalometric contour, intuition and diversification of superposition, deversification of statistic analysis, integrated information collection and convenient search. Conclusions: The system can be used in clinic and research.

Objective To discuss the feasibility of alternant indwelling trocar in bilateral axillary veins to replace the PICC in NICU, and then low down the medical cost for patients when guarantee the safe of treatment. Methods Results Divided 40 premature infants and intensive care infants into control and experimental group randomly, there were 20 infants in each group. Alternant indwelling trocar in bilateral axillary veins was used in the experimental group, the PICC was used in the control group. Compared the clinical effects and the medical costs in the 2 groups. Results The method of alternant indwelling trocar in bilateral axillary veins could reach the satisfactory clinical effects with lower medical costs than PICC. Conclusion Using alternant indwelling trocar in bilateral axillary veins to replace the PICC is safe and feasible. [

Objective: To develop a computer-aided cephalometric analysis system running under the environment of Windows 9X/NT and based on screen input of landmark and contour line. Methods: The analysis system was made with object-oriented method, the program was written with Visual Basic 6.0 and Access 8.0, and the data on the screen was converted. Results: Cephalometric landmark points and contour lines were input through computer screen, then analyzed (22 modes), superposed and managed statistically. The system showed the advantages of using popular hardware, good compatibility, easy expansion, friendly user interface, simple input of landmark points, artful input of cephalometric contour, intuition and diversification of superposition, deversification of statistic analysis, integrated information collection and convenient search. Conclusions: The system can be used in clinic and research.

Objective To investigate the relationship of diabetic nephropathy with serum endothelin-1(ET-1) and C-reactive protein(CRP). Methods Levels of blood pressure, glucose, lipid, creatinine,ET-1,CRP and urinary albumin excretion(UAER) were measured and calculated in 86 patients with type 2 diabetes mellitus(T2DM)and 30 healthy subjects. Results Serum ET-1 and CRP were significantly higher in T2DM than in control(P<0.05，P<0.01).Serum ET-1 and CRP were increased with increment of serum creatinine and UAER(P<0.05，P<0.01). Conclusions Serum ET-1 and CRP may be involved in the development and progression of diabetic nephropathy.

Objective　To better understand the clinical characters of juvenile onset spondyloarthropa-thies (JSpA).Methods　The clinical and laboratory data of 190 in-patients with JSpA were analyzed and the diagnosis,classification and differentiation of juvenile onset arthritis were discussed.Results　Among these 190 patients,163 were male,with a male to female ratio 6∶1.Of them 92.1% had the disease after the age of 8.Peak of age at onset was 12 to 15 years;157(82.6%) patients had peripheral arthritis and only 23(12.1%) patients felt low back pain at onset.During the disease course, peripheral arthritis was found in 187(98.4%) patients and the history of low back pain or buttock pain was recorded in 123(64.7%).The interval between peripheral arthritis and low back pain was from 0 to 20 years,with an average of (3.2±4.5)years.Extra-articular features including enthesitis in 67(35.3%)patients,dactylitis in 20(10.5%),iritis in 9(4.7%) were observed.HLA-B27 was positive in 87.9%(160/182) patients.Sacroiliitis on X-ray was observed in 76.0%(136/179) patients,and 106(55.8%) patients were diagnosed juvenile ankylosing spondylitis (JAS) according to 1984 New York modified criteria.The average disease course in JAS was (6.3±6.2) years,longer than that in JSpA (P＜0.01).Conclusion　The concept of JSpA is helpful to early diagnosis and treatment of juvenile onset arthritis.The JSpA are characterized by asymmetric lower limb predominant oligoarthritis,a wide spectrum of extra-articular features,presence of HLA-B27 and familial history of SpA or psoriasis.It will take an average of 6.3 years for JSpA patients to fulfill the diagnostic criteria of adult AS.

Objective To investigate the feasibility of segmental splenectomy for treatment of splenic benign tumor. Methods The clinical data of 6 patients with splenic benign tumor treated in our hospital with spleen-preserving surgery in the past 2 years were retrospectively analyzed. Results All the 6 patients successfully underwent surgery and recovered smoothly after operation. No acute severe infection occurred. Ultrasonography showed that the blood supply of residual spleen was of no problem. The components of peripheral blood had no significant changes after operation. Conclusion As long as we know the vascular anatomy of spleen well, segmental splenectomy is safe, reliable and feasible.