The production of IL-2 by peripheral blood lymphocytes from patients with Ankylosing Spondylitis (AS)and Rheumatoid Arthritis (RA) was compared with that of healthy controls. Patients with AS and RA showed a significant overproduction of IL-2.Membrane-bound IL-2 receptor was recognized by monoclonal anti-Tac antibody by using a flow cytometry. There was a marked increase of IL-2 receptor in patients with RA, while the level of IL-2 receptor in patients with AS was comparable to that of normal controls. The results suggested that there was obvious abnormalities of membrane-bound IL-2 receptor expressing and production of IL-2 in patients with AS and.RA which may contribute to the pathogenesis of these diseases.

Acquired immunodeficiency syndrome (AIDS) is a serious infectious disease caused by human immunodeficiency virus (HIV). Increasing cases of HIV infection have been detected in adolescents. Intravenous drug abuse and sexual behavior, which are affected by various individual and environmental factors, are the major ways of HIV infection. The current situation and influential factors of HIV infection in adolescents are introduced in this paper.

The paper analyzed the development and main problems of medical records management in hospitals,and proposed a number of measures based on the ongoing healthcare reform for medical records management in the hospitals.These include targeted management; innovative management model to enhance service; enhanced information security for better protection of patient privacy and hospital's intangible assets; modern management theories and technologies for resolving remaining problems in medical records management; scientific building of medical records quality control system.On such basis,the paper discussed the development trend and strategy of hospital medical records management.

In order to study of etiology, pathogenesis, and therapy of endometriosis(EM) through animal models, we review the literature on rodent and primate models of endometriosis, including establishment of models and their applications.We hope that animal models provide useful tools for the studies of endometriosis.

Objective As a special type of chronic pancreatitis, autoimmune pancreatitis ( AIP ) is gradually being recognized?In 2001,researchers found that serum IgG4 levels were significantly increased in AIP patients,2% of chronic pancreatitis was 1?AIP; 1?AIP was considered a systemic disease associated with IgG4?So far,a number of autoimmune antigens associated with 1?AIP have been identified,but the role of IgG4 in the disease is certain,because the pathogenesis of the disease is not sure,the diagnosis and treatment of AIP is not optimistic.

Aim: To investigate the expression and the regulation of Bim protein in leukemic cell of patient with chronic myelognous leukemia(CML). Methods: The primary leukemic cells from the peripheral blood or bone marrow of patients with CML were isolated and cultured. The expression of Bim in the present or absence of ima-tinib(BCR/ABL inhibitor) was detected by the Western blotting, immunohistochemical analysis and real-time quantitative PCR. Results: Bim was consecutively expressed in normal bone marrow, but significantly decreased in the bone marrow of patients with CML( P < 0. 05). Imatinib significantly enhanced Bim mRNA transcription and expression in the manner of time- and dose-dependence. Moreover, there was reverse correlation between Bim protein level and the percent of leukemic cell in bone marrow( r =0. 849 1, P <0. 05). Conclusion: Bim is the Bcl-2 family pro-apoptitic factor. The decreased expression of Bim could be vital in the CML, Bim protein up-expression following the suppression of BCR/ABL might be of importance in investigation of the Bim-induced ap-optosis for potential clinical therapy.

The important difference between post-graduate and undergraduate education is to train their reseach ability,which is very important especially to the post-graduate students of basic medicine who will be researchers.The problem in training research ability of post-graduate was studied in this paper and solution plan was put forward.

Objective To investigate the relationship of diabetic nephropathy with serum endothelin-1(ET-1) and C-reactive protein(CRP). Methods Levels of blood pressure, glucose, lipid, creatinine,ET-1,CRP and urinary albumin excretion(UAER) were measured and calculated in 86 patients with type 2 diabetes mellitus(T2DM)and 30 healthy subjects. Results Serum ET-1 and CRP were significantly higher in T2DM than in control(P<0.05，P<0.01).Serum ET-1 and CRP were increased with increment of serum creatinine and UAER(P<0.05，P<0.01). Conclusions Serum ET-1 and CRP may be involved in the development and progression of diabetic nephropathy.

ObjectiveFrom the view of the frequence of codes applying,investigate the situation of the Tenth Revision of the International Classification of Disease Clinical Modification of Beijing and to support the further development and application.MethodsFigure out the difference of the frequence of codes between before and post application of coding on clinical modification,to compare and make analysis for them.Results Got lists of percentage periods frequence of codes on classification of disease calculated from all secondary and above level hospitals in Beijing in the year of 2006,2007 and 2008.Conclusionthe Tenth Revision of the International Classification of Disease Clinical Modification of Beijing is well compatible with WHO ICD-10 on the level of applicable codes set; the refine work is effective and balance for codes applying; the localization should be done first before applying ICD-10.

30 mm Hg) was diagnosed with Doppler echocardiography in 28 patients with SSc.Twenty patients have isolated PHT,while 8 patients were of secondary PHT which was due to severe pulmonary fibrosis.The levels of albumin, ? globulin ,IgA,IgG and CRP in serum of patients with PHT were significantly higher than those without PHT ( P