Objective: To observe the stability of tinidaz ole mixed with cefradin in glucose injection under room temperature or 37 ℃ for 8 hours.　Methods:Concentrations of tinidazole and cefrad in were determined by ultraviolet spectrophotometry and pH by a pH meter.　Results: The concentrations of tinidazole and cefradin and the pH of the solution did not change significantly under room temperature and 37 ℃ for 8 hours.　Conclusions: Tinidazole can be mixed with c efradin in glucose injection for clinical use under room temperature or 37 ℃.

Japan’s long-term care insurance takes grassroots governments as its insurer and the elderly and part of the non-elderly as its insured;The costs is shared by government、society和individual, and is, payed through isti-tutions, communities and hothes. Since its establishment, its security level has been increasing, the role of preven-tion has been rising, the status of community-based and home-based has been highlighting, and the cooperation a-mong relevant industry has been strengthening. But at the same time, its costs was soaring during the past decade, and the continued development of the system is facing transformation pressure now. Take this as a warning, the devel-opment of long-term care in China should learn its strong points, but also try to avoid its shortcomings.

The paper analyzed the development and main problems of medical records management in hospitals,and proposed a number of measures based on the ongoing healthcare reform for medical records management in the hospitals.These include targeted management; innovative management model to enhance service; enhanced information security for better protection of patient privacy and hospital's intangible assets; modern management theories and technologies for resolving remaining problems in medical records management; scientific building of medical records quality control system.On such basis,the paper discussed the development trend and strategy of hospital medical records management.

Moyamoya disease is an uncommon chronic progressive occlusive cerebrovascular disease.It is mainly involved in the terminal internal carotid artery and the proximal portions of the anterior cerebral and middle cerebral arteries.Normally,there are differences between the conventional angiographic findings and the clinical manifestations and outcomes in moyamoya disease,while the perfusion imaging can provide important hemodynamic information.Currently,CT perfusion imaging and magnetic resonance perfusion imaging have been widely used in clinical practice.This article reviews the application of the two imaging techniques in moyamoya disease.

BACKGROUND:Fewer ethical issues exist in adult stem cells, and some operating technologies are relatively mature. Therefore, to construct tissue-engineered salivary glands using adult stem cells is very attractive and seductive with an extremely important application prospect. OBJECTIVE:To establish a rat model of salivary gland injury by ligation of the main excretory duct of the submandibular gland and to explore the existing feasibility and location of adult stem cells in the injured models. METHODS:The main excretory duct of the right submandibular glands was ligated in Sprague-Dawley rats. After 1 week, rats were kil ed to remove the bilateral glands that were then subject to hematoxylin-eosin staining, PAS glycogen staining and immunohistochemical staining for determination of CK-19, Bcl-2, Ki-67. After that, we compared the normal submandibular gland with the damaged model after ligation of main excretory duct. RESULTS AND CONCLUSION:The rats showed differences in the volume and mass of the affected and normal submandibular glands. The normal submandibular gland was oval, ruddy, smooth, soft with an intact envelop. After ligation, the injured submandibular gland appeared to have atrophy with dark red in color, irregular morphology, envelop congestion, and rough texture;the surrounding vessels showed compensatory expansion. PAS-positive gland cells disappeared, CK-19-postive smal duct epithelial cells proliferated, and laminin-positive cells that were rarely found in the normal gland existed around the duct. In addition, Bcl-2/Ki-67 positive cells were both increased. These findings indicate that stem/progenitor cells may be located in the periductal area of the submandibular gland;and the model of submandibular gland injury established by ligation of the main excretory duct is effective to activate stem/progenitor cells in the submandibular gland.

Objective:To explore the propagable experience and methods of controlling the rate of cesarean sec-tion through the summary of the innovative measures in four counties. Methods:The cases of natural birth and cesare-an section from 2009 to 2013 in four counties were analyzed respectively. The interventions of controlling cesarean section rate have been summarized. Results:The average cesarean section rate of four counties in five years is on the decline, since 2009 the rate were 60. 2%,62. 3%,59. 3%,51. 4%,48. 1%. Conclusions: The interventions really worked, but did not do the best. Improving the social attention on these innovative measures, strengthening surveil-lance mechanism, regulating the medical behaviors of delivery hospitals, enhancing the midwifery training and promo-ting the interventions under the coordination of local government can further reduce the rate of cesarean section.

Objective To discuss the application of image sensor in wireless endoscopic micro-electro-mechanical-system (MEMS). Methods Through the comparison of various types of image sensors, and in the consideration of the environment and requirement inside the body, CMOS image sensor which can output analog image signal with high density of integration, low power consumption, small profile was chosen as the sensor component of a wireless endoscope. The profile and power consumption of some specific models of this type of image sensor were compared and analyzed.Results The problems, such as ground connection, crystal configuration and the layout of circuit board, were reasonably solved during the design of image sensor's schematic circuit diagram. The image capture module based on OV7930 sensor was designed and manufactured. Images were successfully captured during the animal experiments.Conclusion The application and design of image sensor in a wireless endoscopic MEMS are feasible.

The occurrence of breast cancer is closely related to genetic factors.BRCA1 and BRCA2,breast cancer susceptibility genes,play important roles in the occurrence and development of breast cancer.The researches on germline mutations in BRCA1 and BRCA2 are of great significance in prevention,diagnosis and treatment of breast cancer.

Anastomotic leakage was one of the severe complications after anterior resection of rectal cancer.Its occurrenc was correlated with age,weight and nutrtion,basic diseases,preoperative radio-chemotherapy,surgical technique and stage of the tumor.Anastomotic leakage could be diagnosed by symptoms,physical signs,drainagefluid and imaging examinations.Most of the anastomotic leakage could be cured non-operatively.Much attention should be pay on the prevention of anastomotic leakage,protective stomy should be made in high risk population,while the complications of protective stomy should be pay attention to.

[Objective] To investigate the effect of salvianolate injection on the levels of Serum interleukin-1β(IL-1β)and interleukin-18(IL-18) in acute exacerbated chronic obstructive pulmonary disease(AECOPD) patients. [Methods] Fifty-eight patients with acute exacerbated COPD from Respiratory Dep. of thrid Hospital Affiliated to Zhejiang Chinese Medical University, were randomly assigned to the treatment group(28 cases) and the control group(30 cases). Routine therapies for COPD were given to patients in the control group, while 20mg salvianolate injection was given to those in the treatment group by intravenous dripping, once daily for total 10 days. The levels of IL-18, IL-1β and blood gas analysis were evaluated before and 10 days after therapy. The levels of the cytokins were compared with 30 normal controls. [Result] There were no significant differences in the value of IL-1β,IL-18,arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2) before treatment between two groups. Compared with the blank control group, the levels of serum IL-1β,IL-18 in patient with AECOPD were increased significantly( P<0.01). When compared with before treatment and with the control group, the levels of IL-1β,IL-18,PaCO2 decreased more significantly in the treatment group after treatment.The PaO2 in treatment group was higher than in control group. There were significant differences between two groups.[Conclusions] Salvianolate injection can reduce the secretion IL-1β, IL-18 in patient with AECOPD, which maybe through certain anti-inflammatory effects to improve clinical efficacy of COPD pa-tients.