0.05). But the Wuling Sang could obviously decrease serum TG content than Simvastatin(P0.05). The adverse drug reactions were stomach discomfort(4 patiens in SWS) group, 5.71%), abdominal discomfort(2 patiens in Simvastatin group, 4.55% ) and sleeplessness(5 patiens in Simvastatin group, 11.4%) . CONCLUSION: The results show the TCM drug SWS is effective and softy on treating the patients with primary hyperlipemia.

Objective To explore the effect of health education with integrated traditional Chinese and western medicine on patients with cardio-cerebrovascular disease, in order to reach the aim of preven-tion and treatment of cardio-cerebrovascular disease, promotion of early rehabilitation and maintenance of health in them. Methods 80 cases of patients with cardio-cerebrovascular disease were randomized into the control group and the intervention group with 40 cases in each group, Both groups received routine treatment, the intervention group received health education based upon routine treatment. Questionnaires were formulated to investigate change of bad habit and primary disease,return visit and incidence of compli-cation one year after intervention, X2 test was adopted. Results The change rate of bad habit was higher, the change rate of primary disease,rate of return visit and incidence rate of complication were lower in the intervention group compared with those in the control group. Conclusions Health education with inte-grated traditional Chinese and western medicine for patients with cardio-cerebrovascular disease can in-crease their cognition of self- care,life quality and health level which is worthy of wide application in clinic and community.

Gastroenterology ; Humans

Neutrophil genatinase-association lipocalin(NGAL)is a kind of lipocalin of binding proteins that seems to be a popular topic studied much recently,which at first was considered as endogenous bacteriostatic agent.It is bound up with the occurrence,development and prognosis of many kidney diseases.Therefore,it can provide new idea and method on clinical diagnosis and treatment by further study on expression and significance of NGAL in kidney diseases.

Objective To analyze clinical characteristics, hospital treatment, complications and mortality differences of the patients with acute myocardial infarction (AMI) by conventional treatment. Methods Retrospective analysis of 426 cases of AMI patients, aged 20-103 years [mean age(67. 82 ±0. 56) years] ,male 261 cases,female 165 cases, the general condition of patients were recorded, history features, diagnosis, treatment, complications and prognosis. Comparison of elderly(≥70 years) and non-elderly(＜70 years) ,male and female patients with clinical features, treatment, complications and mortality differences. Results Compared with the non-elderly patients with AMI,elderly patients had significantly lower smoking history(P＜0.05) ,female ratio,history of old myocardial infarction rate, cardiac function≥Killip Ⅲ level was significantly higher(all P＜0.05). During hospitalization in patients of different ages diuretics,β blockers, digitalis, clopidogrel and other drugs, application of a significant difference (all P＜0.05). Elderly AMI patients with complete left bundle branch block,atrioventricular block,atrial fibrillation,the incidence was higher than non-elderly patients (all P＜0.05) ,but no difference in mortality between the two groups (P＞0.05). Female patients than male patients with age of onset was significantly (P＜0.05) , and the smoking rate is low,but clearly the high rate of angina died(P＜0.05) ,sub-poor cardiac function after myocardial infarction(P＜0.05). Application of cardiac drugs in addition to nutrition than men,female patients, the rate of other conventional therapy,no difference in both complications and prognosis(all P＞0.05). Conclusion AMI was the major diseases threatening human life,different age had its own clinical characteristics of patients,and it could not be impacted by gender.

AIM: To observe the clinical effect of the Yiganjiedu capsule (Cortex Phellodendri, Radix Scutellariae, Radix et Rhizoma Rhei, etc) on treating hepatitis B. METHODS: The patients in the treatment group were given orally Yiganjiedu capsule, 4 capusles, three times a day, 6 months for a period of treatment. The results was compared with that of hepatitis protecting combination treatment group, Lamivudine group and INF ? group. RESULTS: The normalization ratio of ALT was 55.56%(9/18). The HBeAg negative rate was 11.11%(2/18). The HBV DNA negative rate was 44.44%(8/18), which was higher than that of the group by the combination treatment group ( P

Objective:To study the influencing factors in school and family for children's subjective life quality.Methods:The elementary school students of grade 4～6 were measured with the questionnaire about subjective well-being in children and self-control parents' questionnaire.Analysis of variance or x 2 test was made in order to study the influence of school and family factors on subjective life quality among children.Results:The academic performance or peer relationship significantly affected the children's subjective life quality in general satisfaction, emotions and cognitions( P

Objective:To study the relative bioavailability and pharmacokinetics of domestic acitretin capsules in 22 healthy male volunteers.Methods:A single dose of 50mg of domestic or imported acitretin was administered by randomized crossover way in 22 volunteers and the plasma concentrations of acitrctin were determined by HPLC.The pharmacokinetic parameters were calculated with 3p97 pharmacokinetic program and the bioequivalency was evaluated.Results:The concentration-time curves of two preparations fitted one-compartment model.The peak plasma levels(C max )of domestic and imported acitretin were 490.51?136.50 and 470.91?118.59ng/ml respectively.The peak time(T max ) were 4.13?1.16 and 3.75?1.18h respectively.And AUC (0～24) were 2891.97?809.60 and 2883.01?905.60ng?h?ml -1 respectively.The relative bioavailability of domestic acitretin capsule was 100.23?11.03%.Conclusion:The result of two one-sided tests suggests that the domestic capsule is bioequivalent to the imported capsule.

Objective:To investigate the inhibition of Eleo-Zedoary solution to human endometrial cancer cell line RL-952 in vitro and its possible mechanism.Methods:Using the MTT assay to display the sensitivity to the drug,the inhibition of Eleo-Zedoary parenteral solution to RL-952 cells in vitro was observed;and using light microscope and transmission electron microscope,the morphological alterations of the cells were observed.Results:The inhibition rate of Eleo-Zedoary parenteral solution to RL-952 indicated both dose-dependent and time-dependent anti-proliferative effect.Microscopically,the large vacuoles in the cytoplasm of the cells were found.Ultramicroscopically,many fat-like drops and obvious swelling of organelles as well as the mitochondrial cristaes in the cytoplasm of cells were observed.In addition the nucleus concentration and the chromatin fragmentation and coagulation,including the apoptotic bodies were observed.Conclusion:Eleo-Zedoary parenteral solution can inhibit the proliferation of human endometrial cancer cell line RL-952 by induing apoptosis and secondary necrosis.

BACKGROUND:The clinical treatment of thoracolumbar fractures and dislocation of the patients can be treated with pedicle screw fixation through adjacent vertebral segments. With the increased incidence of disease, many problems were found such as fixator loosening and breakage. OBJECTIVE:To compare the effectiveness of vertebral pedicle screw fixation versus cross-segment pedicle screw fixation for thoracolumbar vertebral fracture and dislocation. METHODS:100 patients with thoracolumbar vertebral fracture and dislocation were chosen in the 474 Hospital of Chinese PLA from February 2013 to May 2014. The patients were randomly assigned to two groups (n=50). Patients in the control group were treated with cross-segment pedicle screw fixation, and those in the observation group were treated with the vertebral pedicle screw fixation. Parameters of imaging were compared and observed. RESULTS AND CONCLUSION: Significant differences in the spinal canal area improvement value and internal fixation failure rate were detected between the two groups (P < 0.05), and the observation group was better than the control group. The height ratio of anterior border of the vertebral body was higher at 12 months after treatment than that pretreatment, but Cobb angle was lower than pretreatment (P < 0.05). These data indicate that compared with cross-segment pedicle screw fixation, vertebral pedicle screw short-segment fixation for thoracolumbar vertebral fracture and dislocation obtains more ideal outcomes and higher safety. It is more in line with biomechanics at the same time ensuring the fixing strength.