Patients with chronic renal failure (CRF) are often complicated by a variety of central nervous system and peripheral neuropathy, which are complex, varied, and with serious complications of kidney failure at the end stage. In recent years, due to the blood dialysis method, organ transplantation and other methods, some neurological compli-cations associated with these treatments. Therefore, analysis and identification of complications in CRF patients are of great significance and can improve the survival rate. Common complications were analyzed and evaluated in this pa-per, for which can provide the basis for improvement of the diagnosis and treatment for renal failure.

Objective To observe the clinical effect of atorvastatin in the treatment of acute cerebral infarction and observe the clinical impact of blood rheology. Methods 120 cases of patients with acute cerebral infarction were randomly divided into 60 cases of treatment group and 60 cases of control group. The control group got conventional treatment (compound Danshen injection, Edaravone Ozagrel injection and intravenous drip injection Note, oral enteric - coated aspirin tablets, etc. ). The pationts in treatment group were given atorvastatin calcium based on the conventional treatment. Patients in the two groups were treated for 3 months. The clinical efficacy and blood rheology indicators were observed. Results The total effective rate of the treatment group was significantly higher than that of the control group ( P

11 patients with chronic hepatitisB virus(HBV)infection were studiedby enumeration of T cell subsetsin peripheral blood withStaphylococco-SRBC DoubleRosette Forming Technique.It was found that T_3~+ cell subsetwas higher and T_4/T_8 ratio was sig-nificantly lower in patients withchronic HBV infection than in con-rol and higher numbers of doublelabeled cells (expressing both T_4 andT_8 antigens) were also found in pa-tients with chronic HBV infection.

Objective: To investigate the risk factors of deep vein thrombosis after stroke. Methods: A retrospective analysis was made on the 420 cases patients with stroke in our hospital, according to the situation thrombosis were divided into thrombosis group and non-thrombosis group, compared two groups of patients with general information, and many factors with the significant indexes were retrospectively analyzed. Results: Age≥70 years old, bedridden, Wells score≥2 points lower limb NHSS score≥3, anticoagulant therapy, higher admission D-2 dimer, lower BI score and non-rehabilitation therapy were independent risk factor for stroke in patients with acute DVT. Age≥70 years old, bedridden, leg NHSS score≥3 points, the acute stage of DVT and BI score were the independent risk factor for stroke patients follow-up period of DVT. Conclusion:There are many related risk factors for stroke in patients with deep vein thrombosis, these factors should be used to carry out monitoring and preventing deep vein thrombosis, active rehabilitation and anticoagulant therapy should be taken to improve the prognosis of patients with stroke.

Objective To determine whether pancreatic ductal preservation(pancreatic ductal injection of sparing TIUW solution at the time of pancreas procurement)can improve islet yield and function after cold preservation of pancreas.Methods Pancreases were classified into five groups:fresh pancreases(group1 ,n= 10);preserved for 6 hr in TIUW solution without and with pancreatic ductal preservation by TIUW solution(group2, n=10 and group3, n = 10);preserved for 24 hr in TIUW solution without and with pancreatic ductal preservation by TIUW solution(group4 ,n= 10 and group5,n= 10).Dithizon(DTZ)staining was used to identify islet morphous and yield, trypan blue uptake(TBU)was used to assess the nonviability of islets, the insulin secretory response to glucose was used to evaluate islet function in vitro, islet transplantation was used to determine islet function in vivo.Results Islet yields per pancreas after purification in group 1 to 5 were 590± 127, 272 ± 50,454 ± 65, 253± 56, 447 ± 66(islet equivalent ± SD), respectively.Percentage of nonviable islets in grouplto5were(5.7±4.2)%,(18.3±6.5)%,(11.7±4.2)%,(26.3±5.6)%,(15.0±5.3)%.Stimulation index in group 1 to 5 were 7.32±2.32, 4.81±1.17, 7.56±2.44, 2.88±1.00, 5.71±1.90.Cure rates in group 1 to 5 were 100%, 0%, 100%, 0%, 70%.In this study, the differences were significant between control groups and experimental groups(P＜0.05, group 2 vs.group3 and group4 vs.group5).Conclusion The pancreatic ductal preservation can improve islet yield and function.

Oncolytic adenovirus is known to carry out the transformation of adenovirus,which has kill-ing role on tumor defective gene phenotypes,and Can be used as vector for tumor targeted tbempy drugs.At pres-ent,H101 and dl1520 and other biological products are gained from adenovirus type 5-specific gene fragments,which targeted tumor cell defects in the p53 gene expression,can specifically recognize tumor cells and Carry out proliferation and lysis of tumor cells.These biological products can be used as vectors to carry the anti-tumor genes and result in more powerful anti-tumor effects.

Osteoporosis is a disease that threatens human health seriously.Orthopedics plays a very important role in the prevention and treatment of osteoporosis.Teachers of orthopedic department should pay more attention to the teaching of osteoporosis and establish specialized courses to make medical students to learn more about osteoporosis in clinical teaching process

OBJECTIVE:To explore consumers’perceptions for pharmaceutical care by community pharmacist when purchas-ing OTC drugs. METHODS:Semi-structured interview was conducted for 100 consumers who were recruited in Xingqing District, Jinfeng District and Xixia District of Yinchuan,Ningxia Hui Autonomous Region,their expection for pharmaceutical care by com-munity pharmacists was summarized. RESULTS:Totally 100 residents were interriewed,and 97 completed a full interview with ef-fective interview rate of 97%. Consumers still did not clearly on distinguishing the OTC drugs. The majority of consumers chosen OTC drugs were based on experience and brand,a handful of consumers were under the guidance of community pharmacists. Con-sumers were most concerned about the efficacy,adverse reactions and drug quality in using OTC drugs. Most consumers were not satisfied with the pharmaceutical care in purchasing OTC drugs. Nevertheless,due to a lack of medicine knowledge,consumer had a great demand for pharmaceutical care and willingness to accept it. Low professional level of community pharmacist and staff in current community pharmacy and lack of effective communication between pharmacist and consumer were the obstacles of develop-ing pharmaceutical care. CONCLUSIONS:Because of their distrust on competence of community pharmacist,consumers seek less pharmaceutical care of OTC drugs at community pharmacy though they had expectations on pharmaceutical care of OTC drugs by community pharmacist. Consumers’rely on self-choice of drugs make them exposed to more drug risks.

The ketogenic diet (KD) is a similar diet fasting state that is high in fat and low carbohydrate.KD is used in the treatment of refractory epilepsy,but the mechanism is not completely clear.According to the current research progress,the mechanism of KD is antiepilepsy.This paper reviewed the progress of the application of KD in the elucidation of several metabolic diseases and epilepsy syndrome caused by epilepsy.With the further development of the antiepilepsy mechanism of KD in the future,it will not only guide the application of more diseases,but also provide a scientific theoretical basis for the discovery of new antiepileptic drugs.

OBJECTIVE:To discuss the health risk links involved in self-medication of Chinese urban residents. METHODS: Based on literature study and the experts consultation, the high risk links of the self-medication were defined according to the process of self-medication behavior and the probability of the health harm involved in the self-medication behavior, and the intervention suggestions were put forward for the health risks. RESULTS & CONCLUSIONS: The health risk links involved in self-medication of Chinese urban residents appear as 6 links include self-diagnostic error, incorrect drug choice, failing to understand or follow drug package inserts in taking drugs, irrational drug use, unaware of the drug contraindication, disregarding the physiological particularity of the special drug users. Carrying out education on self-mediation and behavior management among the residents, and reinforcing the government control are the effective ways to reduce the health risk of self-medication.