A prospective, comparative and random study was performed on 75 cases of partial and total gastrectomy, gall duct operation and splenectomia, the post operation transfusion of 500ml Haes Steril 6% solution, Gelafundin, Ringerlactat solution had restored and improved the hemodynamic state. After the transfusion the central venous pressure index, blood expelling volume and heart output volume had been restored, reached to high and stable values in a longer duration, versus 500ml gelafunding solution. The least improvement and restoration of hemodynamic activities were observed with the transfusion of 500ml og Ringer lactat solution.
Hetastarch ; Surgery ; Therapeutics ; Blood

BACKGROUND: Acute normovolemic hemodilution (ANH) entails collecting patients blood immediately before surgery with concurrent fluid infusion to maintain intravascular volume. This reduces the red cells mass (RCM) lost during surgery by lowering the hematocrit at which surgical blood loss occurs. Blood collected from ANH is transfused back to the patient at the end of surgery METHODS: 40 ASA I patients scheduled to elective surgery under lumbar epidural anesthesia were randomly divided into two groups, the ANH group where a pre-computed amount of blood was withdrawn just prior to induction of anesthesia with simultaneous infusion of equal amount of hydroxyethyl starch (HAES-STERIL) and the non-ANH group where no blood was withdrawn nor colloid infused. All patients were monitored based on the following parameters: mean arterial pressure, cardiac rate, central venous pressure, hematocrit, prothrombin activity, platelet count, arterial blood pH and hemoglobin oxygen saturation during the five phases of the study: before hemodilution, during hemodilution, surgery proper, immediate post-op and 24 hours after the surgery. Intraoperative blood loss was likewise monitored RESULTS: Comparative studies of the mean values were curried using one-way ANOVA with Complement Scheffes test and Paired T-test with a p value of 0.05 considered significant. The perioperative changes in the hemodynamic and hematologic parameters were not clinical significant CONCLUSION: The higher final hematotocrit level and the non-requirement for homologous transfusion in the hemodiluted group prove that ANH effective as a blood conservation technique. (Author)
Human ; Adult ; Young Adult ; Adolescent ; BLOOD TRANSFUSION ; HETASTARCH ; SURGERY ; ANESTHESIA

BACKGROUND: Third-generation hydroxyethyl starch (HES) solutions have been developed to minimize negative effects on hemostasis. In normal pregnancy, the coagulation activity increases, reaching a maximum around term. This study examined the effects of hemodilution with HES 130/0.4 (6%) on blood coagulation in parturients in vivo and in vitro. METHODS: Forty parturients scheduled for cesarean sections were assigned randomly to receive either 500 or 1,000 ml of HES 130/0.4 (6%). Rotation thromboelastometry (ROTEM(R)) measurements were performed before and after administering HES 130/0.4 (6%). In addition, blood samples obtained from 20 randomly selected parturients were diluted 10% to 40% using HES 130/0.4 (6%), and ROTEM(R) measurements were performed before and after dilution. The changes from baseline and the effects of dilution were analyzed by ROTEM(R) parameters. RESULTS: Infusions of 500 or 1,000 ml of HES 130/0.4 (6%) in the parturients altered the clot formation time, alpha angle, and maximal clot firmness, although all remained within normal ranges. HES 130/0.4 (6%) affected in vitro blood coagulation in parturients' blood containing 10, 20, 30, and 40% HES. The clotting time was prolonged at each dilution percentage, but remained within the normal range. Other parameters showed an impairment of the coagulation system. CONCLUSIONS: Blood coagulation in parturients may be compromised at high dilution ratios of HES 130/0.4 (6%) to blood. Nevertheless, the infusion of 1,000 ml of HES 130/0.4 (6%) in normal parturients did not significantly affect blood coagulation.
Blood Coagulation ; Cesarean Section ; Female ; Hemodilution ; Hemostasis ; Hetastarch ; Pregnancy ; Reference Values

BACKGROUND: Hydroxyethylstarch (HES) solutions are commonly used for intravascular volume expansion with varying effect on coagulation depending on molecular weight and mode of hydroxyl substitution.Clopidogrel and aspirin have been shown to reduce cardiovascular complications in patients with coronaryartery occlusive disease which renders patients to higher risk of bleeding complications who require surgery.The purpose of this study was to evaluate the effect of HES 200/0.5, 130/0.4 and crystalloid on blood loss and transfusion requirement in patients with recent antiplatelet therapy undergoing off-pump coronary bypass surgery (OPCAB) in a prospective, randomized trial. METHODS: Sixty patients scheduled for OPCAB, who received clopidogrel and aspirin within 5 days of surgery were randomly allocated into 3 groups:HES 200/0.5 (n = 20), HES 150/0.4 (n = 20), and Crystalloid (n = 20).Routine coagulation profile were measured before and 2 days after the surgery.Amount of perioperative blood loss, transfusion requirement and fluids input and output were recorded until 2 days postoperatively. RESULTS: The 3 groups were similar with regard to patients and operative characteristics.There were no significant differences in the amount of perioperative blood loss and transfusion requirement among the 3 groups. CONCLUSIONS: Both HES solutions were safe to use in terms of blood loss and transfusion requirement in patients undergoing OPCAB who received antiplatelet agents within 5 days of surgery.
Aspirin ; Hemorrhage ; Hetastarch ; Humans ; Isotonic Solutions ; Molecular Weight ; Platelet Aggregation Inhibitors ; Prospective Studies ; Ticlopidine

BACKGROUND: Distribution and elimination of crystalloid or colloid solutions during inhalational anesthesia have not been adequately investigated. Hemoglobin dilution and fluid kinetic model have been shown to reveal the distribution and elimination of various kinds of fluids. Therefore, we assessed fluid space changes after Hartmann's solution or hydroxyethyl starch solution (HES) infusion during desflurane anesthesia. METHODS: We infused 20 ml/kg of Hartmann's solution, 8.5 ml/kg of Hextend(R) and 8.5 ml/kg of Voluven(R) during 20 min, after anesthesia induction and before surgical incision, and measured the hemoglobin changes. We used mass balance equations and a fluid kinetic model to evaluate the changes of fluid space. In the fluid kinetic model, we used one volume model, which allows estimation of the size of the body fluid space expanded by the fluid (V) and the elimination rate constant (kr). RESULTS: The expanded plasma volume of three different fluids, calculated using mass balance equations, showed a similar degree of expansion during infusion, however, after finishing infusion, the dilution effect of Hartmann's solution decreased rapidly and lasted less than HES. Fluid kinetic model shows the mean size of V of 12.3 +/-5.9 L for Hartmann' solution, 5.2 +/- 1.6 L for Hextend, and 4.5 +/- 1.6 L for Voluven. Corresponding kr values were 263.0 +/- 161.8, 36.5 +/- 31.8, and 34.1 +/- 21.3 ml/min, respectively. CONCLUSIONS: The distribution volume of intravenous fluids analyzed by kinetic model showed that crystalloid fluid has a similar volume distribution compared to extracellular fluid and HES distributed to a volume larger than blood volume. Analysis and simulation of plasma volume expansion using this model provide a helpful tool for anesthesiologists planning fluid therapy.
Anesthesia ; Anesthesia, General ; Blood Volume ; Body Fluids ; Colloids ; Extracellular Fluid ; Fluid Therapy ; Hemoglobins ; Hetastarch ; Isoflurane ; Isotonic Solutions ; Plasma Volume ; Starch

Systemic capillary leak syndrome (SCLS) is a condition that's caused by the shift of fluid and protein from the intravascular space to the interstitial space as a result of repetitive episodes of capillary hyperpermeability. The pathogenesis of SCLS is still unclear, but there's recently been a report showing this syndrome in association with monoclonal gammopathy. This syndrome can be a fatal disease because cardiovascular collapse can occur in the initial capillary leak phase. Although theophylline, diuretics, terbutaline, steroids, calcium antagonist, Ginkgo biloba extracts and plasmapheresis have been suggested as medication, none of them have been proven to be effective. Considering that this disease is self-limiting, conservative treatment in the acute phase is believed to be very important. Because hypoalbuminemia is very a common manifestation of SCLS, Pentastarch, which has a higher molecular weight than albumin, could be efficient to prevent cardiovascular collapse. We used 10% Pentastarch during the acute SCLS attacks of 2 patients and the patients both showed a dramatic response. Pentastarch may be helpful to treat SCLS in its initial capillary leak phase by the elevating blood pressure, and this might contribute to somewhat decreasing the acute mortality of SCLS.
Adult ; Capillary Leak Syndrome/diagnosis/*drug therapy/etiology ; Capillary Permeability ; Female ; Hetastarch/*therapeutic use ; Humans ; Plasma Substitutes/*therapeutic use

Several papers on respiratory and critical care published from March 2012 to February 2013 were reviewed. From these, this study selected and summarized ten articles, in which the findings were notable, new, and interesting: effects of high-frequency oscillation ventilation on acute respiratory distress syndrome (ARDS); safety and efficacy of hydroxyethyl starch as a resuscitation fluid; long-term psychological impairments after ARDS; safety and efficacy of dexmedetomidine for sedation; B-type natriuretic peptide-guided fluid management during weaning from mechanical ventilation; adding of daily sedation interruptions to protocolized sedations for mechanical ventilation; unassisted tracheostomy collar of weaning from prolonged mechanical ventilations; and effects of nighttime intensivist staffing on the hospital mortality rates.
Critical Care ; Dexmedetomidine ; Hetastarch ; High-Frequency Ventilation ; Hospital Mortality ; Respiratory Distress Syndrome, Adult ; Resuscitation ; Sepsis ; Tracheostomy ; Weaning

Hydroxyethyl starch (HES) solutions are synthetic non-protein colloid solutions used to treat hypovolemia. However, their use is not free from the risk of allergic reactions. A 42-year-old male was scheduled to undergo aortic-iliac-femoral bypass surgery for the treatment of arteriosclerosis obliterans. He had no history of allergy. Two hours after the start of surgery, and within minutes after HES administration, facial erythema, hypotension and bronchospasm developed. HES infusion was discontinued under the estimation of anaphylaxis. The patient received phenylephrine, ephedrine, diphenhydramine and hydrocortisone with hydration. After restoration of vital signs, surgery was performed without complications.
Adult ; Anaphylaxis ; Arteriosclerosis Obliterans ; Bronchial Spasm ; Colloids ; Diphenhydramine ; Ephedrine ; Erythema ; Hetastarch ; Humans ; Hydrocortisone ; Hypersensitivity ; Hypotension ; Hypovolemia ; Male ; Phenylephrine ; Vital Signs

BACKGROUND: Individuals with type O blood are more likely to have reduced factor VIII and von Willebrand factor levels compared to their non-O counterparts. Hydroxyethyl starch (HES), which is widely used for blood volume replacement, can induce coagulopathy. Therefore, we tested whether blood type O patients show more coagulopathy and blood loss than non-O patients after infusion of 6% HES. METHODS: Thirty-four non-O and 20 type O patients scheduled for posterior lumbar interbody fusion (PLIF) involving 3 vertebrae or less from June 2007 to August 2008 were enrolled. Fifteen ml/kg of 6% HES was administered during the operation. Coagulation profiles was checked at pre-infusion (T0), 5 min after the end of infusion (T1), 3 hr after the end of infusion (T2), and 24 hr after the end of infusion (T3). Bleeding was measured during and after surgery for 24 hours. RESULTS: Baseline factor VIII concentration was lower and aPTT was longer in type O patients compared to those of non-O patients. 6% HES infusion decreased most of the coagulation factors at T1 in both groups, which were recovered in a time dependent manner. Factor VIII and aPTT of blood type O patients fell off the normal range at T1. However, other coagulation factors, thromboelastography variables, and blood loss were not different between the groups. CONCLUSIONS: Despite inborn low factor VIII which further decreased shortly after HES infusion, blood type O patients did not show more blood loss than non-O blood type after 15 ml/kg of HES infusion in PLIF surgery.
Blood Coagulation Factors ; Blood Volume ; Factor VIII ; Hemorrhage ; Hetastarch ; Humans ; Reference Values ; Spine ; Thrombelastography ; von Willebrand Factor

BACKGROUND: Total knee arthroplasty (TKR) is associated with a significant loss of blood. Fluid substitution with crystalloid or colloid solutions to correct perioperative hypovolemia is essential. Colloid solutions, and especially hydroxyethyl starches (HES), are used to treat hypovolemia, but they may affect blood coagulation. The purpose of this study was to test the efficacy and the safety of colloid solutions in patients undergoing TKR. METHODS: The patients undergoing TKR were divided into a group that underwent fluid management with Voluven(R) (n = 22) and a group that was managed with Hextend(R) (n = 24). The blood loss, the autotransfused blood volume, the hemoglobin level, the allogenic blood requirement, the urine output and the complications were assessed. RESULTS: There were no significant differences in the amount of blood loss, the autotransfused blood volume, the allogenic requirement, the urine output and the complications between the two groups. CONCLUSIONS: Voluven(R) and Hextend(R) are equally efficacious plasma volume substitutes when performing TKR with an autotransfusion of drained blood.
Arthroplasty ; Blood Coagulation ; Blood Transfusion, Autologous ; Blood Volume ; Colloids ; Hemoglobins ; Hetastarch ; Humans ; Hypovolemia ; Isotonic Solutions ; Knee ; Plasma Volume ; Postoperative Hemorrhage