Objective: Exploring the effect of three-flap paltoplasty in preventing anterior palatal fistula for patients whose anterior fissures measured more than 0.5 cm. Methods: 12 patients aged 18-24 months with unilateral complete cleft palate were selected for the implementation of three-flap paltoplasty for cleft palate repair. Briefly, three-flap paltoplasty is based on the traditional two-flap paltoplasty method and involves the creation of a mucoperiosteal flap A in the contralateral palate in front of the fissure margin that is approximately half the size of the anterior palate. The flap A was sutured to the edge of the contralateral nasal mucosa, and the mucoperior flap of both sides of the loose fissure was sutured in layers, and the suture was removed two weeks after surgery. The recovery of cleft palate was observed. Results : All patients were followed up for 3 months, and 12 patients underwent successful repairs with no fistula and other complications. Conclusion Three-flap paltoplasty is an effective method of preventing anterior palatal fistula.