OBJECTIVE:To discuss the approach for clinical pharmacists to participate in the drug treatment.METHODS:The contents and importance for clinical pharmacist to participate in ward rounds and discuss with doctors about the optimal dosage regimen were introduced.RESULTS & CONCLUSION:A satisfactory outcome was able to be achieved through efforts of both clinical pharmacists and physicians to modify and work out a new individualized dosage regimen.Clinical pharmacists can offer direct,responsible drug-related pharmaceutical care for patients by making fully use of the related pharmaceutical knowledge they have mastered.

0.05),with the determination result of the whole blood-diluted sample more similar to that of the undiluated one.CONCLUSION:Whole blood sample of cyclosporine can be stored stably at room temperature at least for 2 weeks.Cold storage is the best storage method and blank whole blood was proved to be the best dilution solvent.

Objective To analyze the anesthesia effect of droperidol and pethidine hydrochloride in combina-tion with paracervical block in artificial abortion.Methods 386 patients undergoing artificial abortion were admitted. They were randomly divided into the two groups.The study group(193 cases)was treated with droperidol and pethi-dine hydrochloride in combination with paracervical block,while the control group (193 cases)was treated with droperidol and pethidine hydrochloride only.The analgesic effect,hemodynamics,cervix relaxation and side effects between the two groups were compared.Results The analgesic effect of the study group was 9 1 .7%,which was much higher than 72.0% of the control group(χ2 =25.198,P<0.01),and there were significant differences between the two groups in hemodynamics(t=4.545,3.674,all P<0.01).The total cervix relaxation were 102 cases,and partly cervix relaxation were 69 cases in the study group,which were significantly higher than that of the control group (69 cases,60 cases,respectively;Z=4.643,P<0.01).There was no difference between side effects except for abor-tion syndrome(χ2 =7.580,P=0.006).Conclusion Droperidol and pethidine hydrochloride in combination with paracervical block have an excellent effect on artificial abortion.

Objective:To investigate the principle of anesthetic management for intracranial aneurysm.Method:The anesthetic regimens of 34 cases of intracranial aneurysm were analyzed.Controlled lowering of blood pressure and protective measures for brain were implemented introperatively to prevent rapture of cerebral aneurysm and postoperative cerebrovascular spasm.Intraoperative ECG,MAP,HR,NIBP and SPO2 were monitored and the HR,MAP before and after induction phase were compare.Result:The effects of anesthesia and lowering of Bp were satisfactory,no death occurred intraoperative!y,and aneurysm ruptured m one case.The H-Rs of whole group during induction phase were not decreased as compared with those before induction phase,and the decrease of MAP was extremely significant as compared with that after induction phase.Conclusion:The effect on parts of brain should be considered when choosing narcotics and hypotensors.Perioperative brian protection could reduce the postoperative incidence rates of arterial spasm and cerebral infarction.

OBJECTIVE:To study the correlation between salivary drug concentration and blood,drug level its clinic sig-nificance.METHODS:The salivary drug concentration and blood drug level of gentamicin of15volunteer cases were deter-mined by radioimmunoassay.RESULTS:Both blood drug level and salivary drug concentration of gentamicin reached to peak level1hour after medication.CONCLUSION:The blood drug level of gentamicin and the salivary drug concentration of gentamicin are positively correlated,i.e.it is possible for salivary to substitute for blood in the therapeutic drug monitoring of gentamicin.

Humanities ; Knowledge ; Medicine

OBJECTIVE: To optimize the extraction technology of Huanggan decoction. METHODS: The extraction technology of Huanggan decoction was optimized by L9(33) orthogonal design with the concentration of alcohol, the amount of solvent and the extraction time as factors taking the contents of chlorogenic acid as indexes. RESULTS: The optimal extraction process was as follows: adding six and five-fold of 70% alcohol, extracting for 60 min and 45 min. CONCLUSION: The extraction technology has been proved to be reasonable, simple and feasible, and it provides theory evidence for production.

The paper concluded systematically the progress of study on KCNQ1 in recent years.Firstly,the structure of ? subunit or ? subunit and its interaction between each other were explained in the paper.Secondly,the physiological function of complex KCNQ1/KCNE was interviewed,such as many kinds of inherited cardiac arrhythmias induced by mutation of KCNQ1 or KCNE and secretion of KCNQ1 in different epithelial cells.Eventually,the paper introduced the study of antagonists and agonists on KCNQ1 channel.

Objective To discuss the clinical distribution and antibiotic resistance of 1909 strains of Pseudomonas aeruginosa(PA)to 19 antibiotics.Methods To collect and isolate clinical specimens from Jan to Dec in 2007,and analysis the drug resistance of 1909 stains of PA.Results The top three departments of infection rnte are Senior Officials inpatient Ward(38.9%),Neurology Department(28.1%)and Pneumology Department(19.58%).The drug with the highest level of antibiotic resistance is Trimethoprin/Sulfa(96.3%),the second one is Tetracycline(95.3%),and drugs with low level antibiotic resistance are imipenem(39.8%),Ceftazidime(29%),Piperacillin/Tazobactam(28%),amikacin(14%),respectively.Conclusion PA is a main pathogenic bacteria for bedridden patients and critically ill patients in ICU.It's important to choose antibiotics reasonably,and it's necessary to acontrol the path of hospital-acquired infection.

Objective:To explore the effect of intraventricular administration of insulin on pro-apoptotic expression of Caspase-3 mRNA and neuronal apoptosis in hippocampus CA1, and neurological function after rats’ CPR. Methods:Thirty male SD rats were randomly divided into three groups:sham group;the resuscitation with saline-treated group and resuscitation with insulin-treated group. Six minute cardiac arrest was induced by ventricular fibrillation (VF) via pacing electrode placed in rats’ esophagus in saline and insulin group. Results:1. The NDS revealed a clear neurological deficit after reperfusion 24 h, 72 h in insulin and saline group as compare to the sham group, Comparing to the saline group, Insulin could improve the rats’ neurologic function after CPR 24 (insulin vs. saline group, 70(64~72)vs.56(50~58), P<0.001);2. Through TUNEL stain, insulin inhibited apoptosis in CA1 hippocampus as compare to the saline after CPR 7d. (F=5.853, P=0.02) 3.Caspase-3 expression in insulin-treated groups were significantly decreased compared to the saline-treated group after reperfusion 24h and 72h[(70(64~72), 56(50~58);P<0.001]. Conclusion:Intraventricular administration of insulin could inhibit the mRNA expression levels of the apoptotic activities of Caspase-3 after cardiac arrest, prevent neuronal apoptosis in the CA1 hippocampus and improve the rats’ neurological function (at least 24hours) after CPR.