1.The enhancement of astrocytic-derived monocyte chemoattractant protein-1 induced by the interaction of opiate and HIV tat in HIV-associated dementia
Journal of Pharmaceutical Analysis 2009;21(4):277-封3
HIV-assodated dementia (HAD) is a public health problem and is particularly prevalent in drug abusers. The neuropathogenesis of human immunodeficiency virus (HIV) infection involves a complex cascade of inflammatory events, including monocyte/macrophage infiltration in the brain, glial immune activation and release of neurotoxic substances. In these events, astrocytic-derived monocyte chemoattractant protein-1 (MCP-1) plays an important role, whose release is elevated by HIV transactivator of transcription (HIV tat) and could be further elevated by opiates. This review will also consider some critical factors and events in MCP-1 enhancement induced by the interactions of opiate and HIV tat, including the mediating role of mu opioid receptor (MOR) and CCR2 as well as the possible signal transduction pathways within the cells. Finally, it will make some future perspectives on the exact pathways, new receptors and target cells, and the vulnerability to neurodegeneration with HIV and opiates.
2.Technological Advances and Medicine: A Narrative Review in the light of COVID-19
The Singapore Family Physician 2020;46(4):59-65
The current global pandemic, known as COVID-19, poses challenges to healthcare systems worldwide. At the same time, it has provoked a collective focus on new
and disruptive technology and stimulated the application of such technologies to disease control and containment efforts. Some of the innovations that have played the most significant roles have come from the fields of artificial intelligence, big data analytics, and
communications technology. The current situation provides a good opportunity to relook how medical people engage with technological advances. This narrative review attempts to provide a historical context to the adoption of technology and of technical developments in Singapore and discusses the impact of disruptive technology in healthcare.
3.The effects of SSTG drug serum on Caclium-CaM-CaMPKⅡ signal system in cardiomyocytes injury induced by hypoxia and reoxgyenization
Chinese Pharmacological Bulletin 2003;0(07):-
Aim To explore the effects of Shuangshen tongguan(SSTG) drug serum on Calcium-Calmodulin(CaM)-Calcium/CaM dependent kinaseⅡsignal system in cardiomyocytes injury induced by hypoxia and reoxgyenization.Methods The cardiomyocytes were deprived of oxygen and glucose to mimic hypoxia reoxygenation injury.Intracellular calcium concentration,calmodulin(CaM) and calcium/calmodulin dependent kinaseⅡ?(CaMPKⅡ?) mRNA were measured by fluorospectrophotometry and reverse transcription-polymerase chain reaction(RT-PCR)respectively.Results After hypoxia/reoxygenation,intracellular calcium concentration,CaM and CaMPKⅡ? expression were enhanced(P
4.The research of drug serum on calcium and NOS-NO system in cardiomyocytes injured by hypoxia and reoxgyenization
Chinese Pharmacological Bulletin 2003;0(10):-
Aim To explore the effects of shuang shen tong guan(SSTG) drug serum on calcium and NOS-NO system in cardiomyocytes injured by hypoxia and reoxgyenization.Methods The cardiomyocytes were deprived of oxygen and glucose to mimic hypoxia reoxygenation injury.Intracellular calcium concentration was determined by Fluorospectrophotometry.NOS activity and NO contents were detected using colorimetric method.Results Intracellular calcium concentration,NOS activity and NO content were increased after hypoxia and reoxygenation injury.SSTG drug serum inhibted the upwards of intracellular calcium concentration,activity of total NOS,indusive NOS and NO content due to hypoxia/reoxygenation injury significantly(P
5.Combined detection of serum CEA,CA199 and CA724 in the diagnosis of gastric cancer
International Journal of Laboratory Medicine 2014;(12):1545-1546,1549
Objective To investigate the diagnostic value of combined detection of serum carcinoembryonic antigen (CEA),car-bohydrate antigen 199 (CA199)and carbohydrate antigen 724 (CA724)for the diagnosis of gastric cancer.Methods Plasma levels of CEA,CA199 and CA724 were detected by using electrochemiluminescence in 95 patients with gastric cancer,63 patients with be-nign gastric diseases and 101 healthy subjects.Results Levels and positive rates of CEA,CA199 and CA724 in gastric cancer group were significantly higher than healthy control group (P<0.05).Levels and positive rates of CEA and CA724 in gastric cancer group were significantly higher than benign gastric diseases group (P<0.05).There was no statistically significant difference of level and positive rate of CA199 between gastric cancer group and benign gastric diseases group(P>0.05).The sensitivity of com-bined detection was obviously higher than any single detection or combined detection of two indexesConclusion Combined detection of the three tumor markers could improve the diagnostic sensitivity and coincidence rate,which have practical diagnostic value for gastric cancer.
6.Application of noninvasive positive pressure ventilation for sleep disordered breathing in China.
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(6):490-491
After more than 30 years of development, noninvasive positive pressure ventilation (NPPV) has become one of the main treatments of sleep-disordered breathing (SDB) in the world. It is the wide application of this technology that makes breakthrough in SDB treatment, and has given rise to a new interdisciplinary area sleep medicine. In China, sleep medicine started in late of 1980's, in recent years, with the development of economy and the improvement of recognization, the application of NPPV in Chinese market has become one of the fastest growing in the world. NPPV technology also extends gradually to the treatments of patients with respiratory failure due to different causes, such as severe acute respiratory syndrome and COPD.
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7.The postoperative analgesic activity of flurbiprofen to intracranial aneurysm patients who went under endovascular treatment
Chinese Journal of Postgraduates of Medicine 2011;34(27):6-8
ObjectiveTo investigate the postoperative analgesic activity offlurbiprofen to intracranial aneurysm patients who went under endovascular treatment with propofol and remifentanil anesthesia.Methods Totally 40 ASA physical status Ⅰ - Ⅱ intracranial aneurysm patients were randomly scheduled flurbiprofen group (group F, 20 cases) and control group (group C, 20 cases). The patients in group F were given flurbiprofen 1 mg/kg respectively at 10 min before operation and at the end of the operation; while the patients in group C were given fat milk at the same time. The patients' circulation of the two groups before and after operation,the headache visual analog scores (VAS) and body comfort score (BCS) were observed.ResultsThe mean arterial pressure(MAP) in group C after operation 1,2 and 3 h were significantly higher than that before operation (P < 0.05 ); the heart rate in group C after operation had no significantly difference compared with before operation (P >0.05). The MAP and the beart rate in group F had no significantly differences before and after operation(P > 0.05 ). The VAS of postoperation headache after operation 1,2 and 3 h were (0.30 ± 0.65 ), (0.30 ± 0.57) and (0.25 ± 0.44) scores in group F, which were significantly lower than those in group C [ (3.25 ± 1.58), (3.00 ± 1.56) and (2.90 ± 1.48 ) scores](P < 0.05 ) ; the BCS after operation in group F after operation 1,2 and 3 h were (3.30 ±0.86), (3.45 ±0.86) and(3.62 ±0.86)scores, which were significantly higher than those in group C [ ( 1.20 ± 1.00), ( 1.45 ± 0.94) and ( 1.50 ±1.00)scores](P< 0.05 ). ConclusionFlurbiprofen can reduce intracranial aneurysm patient's postoperative headache under endovascular treatment.
8.Relationship between circulating endothelial cells and tumor angiogenesis
Cancer Research and Clinic 2010;22(3):211-213
Circulating endothelial cells (CEC) are endothelial cells which are detected in the peripheral blood. There are very few CEC in healthy adults while the number is obviously increasing in patients with arthrosclerosis, diabetes mellitus, lupus erythematosus, et al. Nowadays, flow cytometry analysis and immunomagnetic isolation for CEC are employed successfully in clinic and scientific research. Several research findings have confirmed that there is intimate relation between CEC and tumorigenesis. Because of the important role in angiogenesis and tumor growth, CEC would be a perspective tumor marker in antiangiogenesis and would also predict the chemotherapy efficacy.
9.Advance on the neonatal sepsis
Chinese Pediatric Emergency Medicine 2014;21(8):539-542
Neonatal sepsis is a systemic infection in which bacteria or fungi invade blood circulation and grow in it in the neonatal period,caused by toxin produce from bacteria or fungi.Currently sepsis is the major causing morbidity and mortality in neonatal infectious diseases,its clinical manifestation is not obvious and this brings us a range of clinical problems.In this review,we discussed these characteristics epidemiology,etiology,pathophysiology,clinical features of neonatal sepsis and septic shock in adults,to deepen the understanding of neonatal sepsis.
10.Advance on structural change of the heart during severe sepsis
Chinese Pediatric Emergency Medicine 2014;21(7):455-457
Cardiovascular dysfunction is common in severe sepsis.Although functional alteration is often described,the elevated serum levels of cardiac proteins and autopsy findings of myocardial immune cell infiltration,edema,and damaged mitochondria suggest that structural changes to the heart during severe sepsis may occur and may contribute to cardiac dysfunction.Myocardial functions may be improved by pretreatment with plateletactivating factor,cyclo-sporin A,glutamine,caffeine,simvastatin,or caspase inhibitors.We explored the advance on structural change of the heart during severe sepsis in order to deepen the understanding of these changes.