Fasciitis, Necrotizing ; diagnosis ; Humans ; Intestinal Perforation ; diagnosis ; Rectal Diseases ; diagnosis ; Recurrence

Syncope is a common presenting complaint in pediatric emergency departments. The differential diagnosis of syncope is vast, including various neurological and cardiac conditions. Brugada syndrome (BrS) is a primary inherited arrhythmia which can present with syncope but can lead to sudden cardiac deaths due to ventricular fi brillation. BrS is a rare genetic condition, often diagnosed in the adulthood. BrS presenting in childhood, especially symptomatic BrS, is extremely rare. We present a case of a previously healthy 3-year-old male who presented to the emergency department with syncope and was later diagnosed with BrS.

Ecological attributes of haematozoan parasites are poorly understood. In this study, we report haematozoan prevalence in two species of Indian lizards, Hemidactylus flaviviridis (Family: Gekkonidae) and Calotes versicolor (Family: Agamidae) under three macro-environmental variables: host location, weight and seasonal variations. Hemidactylus flaviviridis (n= 199) and Calotes versicolor (n= 34) were sampled from Bareilly, Chandausi and Mirzapur, Uttar Pradesh, India belonging to different weight groups [Group I (0-5 gm), Group II (5-10 gm) and Group III (10-15 gm)] and during various seasons [Summer (May-July), Rainy (August-October), Winter (November-January), Spring (February-April)] of the year. A haemogregarine, Hepatozoon Miller, 1908 was discovered from both host species. Test for identity of the parasites was conducted by feeding infected Culex quinquefasciatus (Diptera: Culicidae) on infection-free H. flaviviridis and C. versicolor and blood examinations on 22nd day (H. flaviviridis) and 25th day (C. versicolor) post feeding (pf) revealed similar haematozoan parasites and were identified as Hepatozoon lacertilis Gupta et al., 2011. Infectivity from different locations indicated a prevalence of 5.26% (Bareilly) and 16.36% (Mirzapur) in H. flaviviridis whereas infectivity was comparatively higher (19.23%) in C. versicolor. In different weight groups, Group III indicated highest infectivity in both lizards being 21.42% (C. versicolor) and 17.85% (H. flaviviridis). Parasites showed highest prevalence during spring season (H. flaviviridis : 9.52%; C. versicolor : 25%). Values of significance were determined by chisquare test to compare the prevalence within different variables (host location, weight and season). The study has importance for its contribution to the knowledge on the diversity of reptilian hosts infected by haemogregarines. It is the first record of Hepatozoon infectivity in both lizard species with respect to the three macro-environmental variables.

Aged, 80 and over ; Aortic Aneurysm ; complications ; Humans ; Male ; Syndrome ; Tomography, X-Ray Computed ; Vocal Cord Paralysis ; diagnostic imaging ; etiology ; physiopathology

No screening test is ideal for detecting rheumatic diseases; diagnosis depends on appropriate history and thorough physical examination. Sometimes, laboratory investigations may be useful in confirming or ruling out rheumatic disease after a clinical diagnosis is considered. Once a rheumatic disease has been diagnosed, certain laboratory tests can help in assessing prognosis or determining the extent of the disease. Laboratory tests may also help the physician monitor certain rheumatic diseases, guide treatment or assess potential drug toxicity.

AIM: To evaluate and compare subjective and objectively, the course of surgically induced dry eye following both phacoemulsification ( PKE ) and manual-small incision cataract surgery ( SlCS) procedure, and to analyze the result in terms of causative factors.
●METHODS:This single centre prospective study included 100 eyes of 100 patients randomly divided into two groups (Group 1, SlCS-50 patients; Group 2, PKE-50 patients), who underwent cataract surgery with intraocular lens ( lOL)-implantation from Jun. 2013 to Dec. 2014 for a period of one and half year by single surgeon. Ln all patients post operative course of dry eye were tabulated and assessed at 1, 4, 12wk, subjectively and objectively, and thereafter analyzed in terms of possible causative factors. Statistical data were calculated using SPSS 23. 0 Windows software.
RESULTS: There was no significant preoperative intergroup difference in subjective and objective dry eye test (DET) values (P>0. 05). Both the groups showed similar trend of persistently declining objective DET -values till at the end 12wk, as compared to their respective preoperative values (P<0. 05), although there were no significant intergroup changes seen throughout the postoperative period (P>0. 05). PKE seems to have better subjective DET-value at the end of 12wk.
●CONCLUSlON:Dry eye disease is inevitable following cataract surgery. Both PKE and SlCS, can affect the dry eye test values in almost similar manner post operatively till up to 12wk. Randomized multicentre trial with larger cohort and longer follow-up is warranted to substantiate our findings.

The scaphoid is an uncommon site for tuberculous infection. Clinical features and radiographic findings are not necessarily helpful and may lead to a delay in diagnosis and therefore poor treatment results. We report here a case of scaphoid tuberculosis, which presented as a scaphoid fracture, but then progressed to wrist arthritis. The patient was treated conservatively and had good functional outcome. To the best of our knowledge, such presentation has not been documented.

Objective: The present study was carried out to investigate the hypoglycemic effects of the petroleum ether extract of Sesbania sesban (SS)(Merr.) roots, which are widely used in inflammation, fever, ulcers, leucoderma and diabetes in various parts of India. Methods: SS was administered orally at different doses (250, 500 and 1000mg/kg) to normal and streptozotocin (STZ) induced type- 2 diabetic mice. The fasting blood glucose (FBG), biochemical parameters in serum, change in body weight, internal organs weight, food intake, water intake and glycogen level in livers were performed for the evaluation of hypoglycemic effects.Results: All the doses of SS caused a marked decrease of FBG in STZ induced type -2 diabetic mice. SS decreased the cholesterol, triglyceride (TG), urea, creatinine level and increased the insulin, HDL cholesterol, and total protein level. Decrease in body weight and glycogen level induced by STZ was restored. Increase in water and food intake induced by STZ was decreased. Conclusions: The results suggest that SS may have hypoglycemic potential for the type 2- diabetes and support the traditional use of the roots of plant as a hypoglycemic agent.

Recently, the use of herbal medicines has been increased all over the world due to their therapeutic effects and fewer adverse effects as compared to the modern medicines. However, many herbal drugs and herbal extracts despite of their impressive in-vitro findings demonstrates less or negligible in-vivo activity due to their poor lipid solubility or improper molecular size, resulting in poor absorption and hence poor bioavailability. Nowadays with the advancement in the technology, novel drug delivery systems open the door towards the development of enhancing bioavailability of herbal drug delivery systems. For last one decade many novel carriers such as liposomes, microspheres, nanoparticles, transferosomes, ethosomes, lipid based systems etc. have been reported for successful modified delivery of various herbal drugs. Many herbal compounds including quercetin, genistein, naringin, sinomenine, piperine, glycyrrhizin and nitrile glycoside have demonstrated capability to enhance the bioavailability. The objective of this review is to summarize various available novel drug delivery technologies which have been developed for delivery of drugs (herbal), and to achieve better therapeutic response. An attempt has also been made to compile a profile on bioavailability enhancers of herbal origin with the mechanism of action (wherever reported) and studies on improvement in drug bioavailability, exhibited particularly by natural compounds.

Scindapsus officinalis (S. officinalis) holds a reputed position in Ayurvedic system of medicine. It has been ethanobotanically used to treat diarrhea (“atisara”), worm infes-tation (“krmiroga”), and as antipyretic. Literature survey on S. officinalis was carried out via electronic search in PubMed, SciFinder, Scirus, Google Scholar, Agricola and Web of Science and a library search. Results revealed that a very specific botanical description of the plant is still not available. The plant is mistaken within the hybrids and other plants of genus Scindapsus and family Araceae. Since ethnobotanically the plant is of much importance, chemistry of the plant yet needs to be fully explored. Thus the need of the hour is to comprehend the fragmented information available on the botany, traditional uses, phytochemistry and pharmacology of S. officinalis which could help in the correct identification of the sample and avoid adulteration due to mistaken identity.