Kawasaki disease can affect the coronary arteries,including coronary artery dilation,aneurysm,stenosis and thrombus.Conventional coronary angiography is the gold standard for coronary artery evaluation,but there are risks associated with its invasive nature and with the exposure to contrast agents and radiation.With the rapid development,computed tomography angiography and magnetic resonance angiography become the noninvasive imaging modalities to evaluate the coronary artery.

Objective To investigate the effects of alprostadil injection on IL-6, IL-8, TNF-αand insulin resistance in diabetic patients.Methods 90 patients with diabetes mellitus in our hospital from January 2014 to May 2016 were selected,and randomly divided into observation group and control group,45 cases in each groups.The control group received conventional western medicine , the observation group was treated with alprostadil injection.The levels of serum IL-6, IL-8, TNF-α, insulin and insulin resistance index were compared before and after treatment in both two groups. Results After treatment,the total effective rate of treatment group was 91.11%,which was significantly higher than the control group 71.11%( P<0.05).Before treatment,the levels of IL-6,IL-8,TNF-α,insulin and insulin resistance index of two groups were had no statistical significance,after treatment,the levels of IL-6,IL-8,TNF-α,insulin and insulin resistance index were decreased in both groups,and the observation group was significantly lower than the control group,the difference was statistically significant (P<0.05).Conclusion The alprostadil injection can significantly reduce the levels of IL-6,IL-8,TNF-α,and control the level of blood glucose,reduce the effect of insulin resistance.

Objective To investigate the effects of Shenqifuzheng injection on T-cell subsets and oxidative stress in patients with diabetes mellitus . Methods 90 cases of 2 diabetes patients from June 2015 to June 2016 in our hospital were selected and randomly divided into control group and observation group,45 cases in each group,the control group treated with conventional treatment,the observation group was given Shenqifuzheng injection based on the control group.The levels of peripheral blood T cell subsets,serum oxidative stress metabolites glutathione peroxidase,superoxide dismutase and catalase,the control of blood glucose were compared between the two groups.Results After treatment,the levels of Th17,Treg and Th17/Treg in control group compared with before treatment had no significant difference, the levels of Th17 and Th17/Treg in observation group were obviously decreased and lower than in control group (P<0.05);the content of Treg in observation group was increased significantly and higher than the control group (P<0.05).After treatment,the levels of CAT in observation group was lower than control group,GSH-PX and SOD were higher than control group,the difference was statistically significant (P<0.05).After treatment,the GLU,2h PG,HOMA-IR and HbA1C (%) in observation group were significantly decreased than before treatment and lower that in control group, the difference was statistically significant ( P<0.05 ). Conclusion Shenqifuzheng injection can effectively improve the T cell subsets and oxidative stress levels in diabetic patients , help to control blood sugar.

In recent years,traditional English teaching has been greatly affected by network platform.As SMMU has been trying to perfect the Online English Writing Course,the questionnaire completed by the students taking the course shows that the course designs have proved effective in the improvement of research-based learning.

Based on the theory of self-access learning,this paper makes an investigation into some factors which have great influence on the fostering of learner autonomy by the case study of the online English writing course.

Objective To discuss the relative importance of the 5 English skills and to compare medical majors' main purposes of English listening and medical majors' actual usage of English listening.Methods A questionnaire survey was conducted among medical sophomores in the Second Military Medical University who had finished the college English course.Data were processed by Excel 2007 and statistical results were described by percentage.Results Participants paid enough attention to five English skills,especially the listening ability; a total of 98.4％ of the participants recognized the importance of listening skills.Students' learning needs and course arrangements are mainly about examinations,graduations future study.Medical English course arrangements cannot satisfy the learning needs.Conclusions Students recognized the importance of five English skills,especially the listening skills.Students' learning needs are basically examination-oriented and the medical English course is not enough for the students.Suggestions on the English teaching,course design and the integration of college English and medical English are put forward in the paper.

OBJECTIVE:To develop a HPLC method for the assaying of the principal agent in oxiracetam sodium chloride injection.METHODS:The separation was performed on Intersil CN-3column;the mobile phase was a mixture of acetonitri_ le-water(6∶94)with detection wavelength at214nm,flow rate at0.6ml/min and sample size at5?l under room temperature. RESULTS:The linear correlation of oxiracetam was observed over the concentrations of0.5625to288?g/ml(r=0.9999).The average recovery was99.95%(RSD=1.36%).CONCLUSION:The method is accurate,convenient specific and repro-ducible,and suitable for the determination and quality control of Oxiracetam.

BACKGROUND:Clinicaly, patients with constipation often have depression and depression is often associated with symptoms of constipation, but the mechanisms remain unclear. OBJECTIVE:To observe the relation between constipation and depression by establishing animal models. METHODS:A total of 60 specific-pathogen-free rats were divided randomly into three groups: normal group, chronic stress-induced depression model group and slow transit constipation model group. Slow transit constipation model was created by giving the solution of compound diphenoxlate 8 mg/kg daily, for 120 consecutive days. On day 100, chronic stress model rats were subjected to successive unforeseen stimulus for 21 days. Rats in the normal group were regularly housed. Fecal number, dry weight of feces and body weight were recorded once a week. After successful model establishment, fecal number, dry weight of feces, time of first dark stools defecation, sucrose preference, open-field behavior score and forced swim time were detected in each group, and statisticaly analyzed. RESULTS AND CONCLUSION:Fecal number was less in the chronic stress-induced depression model group than in the normal group (P = 0.00), and time of first dark stools defecation was longer (P = 0.00). Fecal number was more in the chronic stress-induced depression model group than in the slow transit constipation model group (P = 0.00), but time of first dark stools defecation was shorter (P = 0.00). No significant difference in fluid consumption, sucrose preference, horizontal and vertical scores of open-field test, and forced swim time was detected between slow transit constipation model group and normal group (P > 0.05). However, above indexes were higher in the slow transit constipation model group than in the chronic stress-induced depression model group (P < 0.01). Results verified that constipation was observed in chronic stress-induced rat model, but depression was not observed in slow transit constipation rat model, suggesting that depression can induce constipation, but constipation does not necessarily lead to depression.

A new leaf spot disease on maize mainly caused by Curvularia lunata( Walk )Boed is becoming prevalent in the north of China The conidia play an im portant role during the disease invasion circulation When we cultivated C lunata on sorghum medium, a kind of black and short columned protuberance was obser v ed on the surface of sorghum Further microscopic examination certified that th is special structure was stroma, a kind of conidiomata of C lunata

Objective To evaluate the clinical value of 9 9 Tc m-HL91 as a tumor positive imaging agent in diagnosis of pulmonary neopl asms. Methods We performed 2 h,4 h planar and 4 h tomogr aphy fusion imaging after injection of HL91 on 42 patients with high probability of pulmonary cancer. Tumor-to-normal tissue background (T/N) ratios were meas ured for all scans. Results T/N ratios at 2 h,4 h planar and 4 h transectional imaging in malignant group were 1.50? 0.17 ,1.71?0.22 and 2.72?0.75, respectively; while in benign group, they were 1.21?0.10,1.25 ?0.22 and 1.49?0.36, respectively. 4 h delay T/N ratios in malignant group we re obviously higher than 2 h ( P 0.05). There were no remarkable differences of T/N ra tios in different phases and histological types of lung carcinoma. Using maligna nt transection ratio ( -1s ) as diagnostic threshold, the sensitivity , specificity and accuracy were 84.85% , 88.89% and 85.71% , respectiv ely. Using transection ratio( +1s ) of benign group as diagnostic th reshold , the sensitivity, specificity and accuracy were 90.91%, 88.89% and 95.2 4%,respectively. Conclusion The results indicate that as a tumor positive imaging agent 99 Tc m-HL91 is useful in diagosising pulmon ary neoplasms.