Objective To systematically assess the clinical efficacy and safety of acupuncture treatment for vertigo with excess syndrome. Methods Chinese and English literature about acupuncture treatment of vertigo with excess syndrome published in recent years was comprehensively searched. The quality of the retrieved literature meeting the inclusion criteria of randomized controlled trial was assessed and its data was collected. A Meta analysis of the included studies was carried out.Results Finally, 10 articles with randomized controlled trials containing a total of 688 patients were included in the analysis. The included literature was assessed at lower quality using Cochrane evaluation member manual 5.1. A Meta analysis showed that the efficacy rate of acupuncture treatment for vertigo with excess syndrome was higher than that of Western drugs alone [M-H OR 4.84, 95%CI (2.39, 9.81),P<0.0001]. Combined acupuncture and Chinese herbal medicine was superior to Chinese herbal medicine alone [M-H OR 3.82, 95%CI (2.06, 7.10),P<0.0001]. Vertigo symptom and function scoring showed day 3 of treatment [MD 4.66, 95%CI (2.97, 6.35)], day 7 of treatment [MD 0.95, 95%CI (0.03, 1.86)] and day 14 of treatment [MD 0.89, 95%CI (0.71, 2.49)]. There were statistically significant differences in the vertigo symptom and function scores between the two groups of patients at day 3 and 7 of treatment. There were no statistically significant differences in the scores between the two groups of patients at day 14 of treatment. Conclusions Acupuncture or combined acupuncture and Chinese herbal medicine are effective and highly safe in treating vertigo with excess syndrome, but high-quality, multi-center and large-sample RCT studies still need to be conducted for validation and support.

Objective By simulating the intermittent hypoxia(IH ) environment of human obstructive sleep apnea syndrome (OSAS) ,to reveal the effect of IH on migratory ability of human peripheral blood derived dendritic cells(DCs) ,and through the in‐tervention of RelB ,p38 expression in order to explore the possible mechanism of the change of DCs migration ability induced by IH . Methods DCs were divided into RelB ,p38 siRNA interfering and non interfering plasmid group before cultivation .The environment of hypoxia was created by a intermittent hypoxia cabin ,among them ,oxygen concentration was 0 .5% ,1 .5% ,5 .0% ,10 .0% ,hypox‐ia/reoxygenation time ratio was set as 1∶1 ,1∶3 ,1∶5 and 1∶9 ,while sustained oxygen was supplied to the contrast at a normal concentration of 21 .0% .The content of RelB and p38 was tested by Western blotting after culture in vitro ,migration ability of DCs was detected by invasion chamber .Results Compared with normoxia ,DCs under IH tended to have declined migratory ability , which was confirmed to be correlated with the average oxygen partial pressure level under IH .IH could promote the expression of RelB and p38 in DCs ,while the migratory ability of DCs was not reversed after intervening the expression of RelB and p38 .Conclu‐sion IH in vitro could cause a decline in migratory ability of DCs ,which may not be induced by activation of RelB or p38 in DCs .

Objective To study the effect of Bushen Yanggan decoction combine with acupoint catgut embedding therapy in the treatment of patients with premature ovarian failure and its influence on serum follicle stimulating hormone(FSH) and estradiol(E2) levels. Methods From January 2016 to June 2017,76 patients with premature ovarian failure in the First People＇s Hospital of Xiaoshan District were selected. They were divided into observation group(n=38) and control group(n=38) by the random number table method. The control group was given western medicine hormone replacement therapy, the observation group was given Bushen Yanggan decoction combined with acupoint catgut embedding therapy. The patients in the two groups were treated for 3 months. The clinical efficacy,clinical symptoms,serum FSH,E2levels and endometrial thickness before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 86. 84% (33/38), which was slightly higher than 78. 95% (30/38) of the control group,but the difference was not statistically significant (χ2=0. 835,P＞0. 05). The incidence rates of soreness and weakness of waist and knees,hot flashes sweating,sexual decline,loss of control of the observation group after 3 months of treatment were 21. 05% (8/38),26. 32% (10/38), 18.42%(7/38),21. 05% (8/38),respectively,which were significantly lower than those of the control group [44.74%(17/38),50. 00% (19/38),39. 47% (15/38),42. 11% (16/38)],the differences were statistically significant(χ2=4. 828,4. 517,4. 094,3. 897,all P＜0. 05). The serum FSH of the observation group after 3 months of treatment was (31. 44 ± 11. 04) IU/L,which was lower than (60. 38 ± 13. 02) IU/L of the control group,the difference was statistically significant(t =10. 447,P ＜0. 05). The serum E2levels,endometrial thickness of the observation group were (92. 77 ± 10. 72) pmol/L,(7. 95 ± 1. 17) mm,respectively,which were higher than those of the control group[(60.24±11.33)pmol/L,(4.82 ±1.65)mm],the differences were statistically significant(t=12. 856,9. 539,all P＜0. 05). Conclusion Bushen Yanggan decoction combined with acupoint catgut embedding therapy for premature ovarian failure has good curative effect,it can improve the clinical symptoms and serum sex hormone levels,increase the thickness of the endometrium,which is worthy of clinical application.