Objective To compare the clinical efficacy between endoscopic thyroidectomy via breast approach and conventional open thyroidectomy in patients with nodular goiter.Methods A series of 75 patients with unilateral nodular goiter was divided into two groups,either receiving endoscopic thyroidectomy through breast approach(Endoscopic Group,24 cases)or conventional open thyroidectomy(Open Group,51 cases).The therapeutic efficacy was compared between the two groups.Results In the Endoscopic Group,the endoscopic operation was successfully performed in 23 cases,whereas a conversion to open surgery was needed in 1 case because of large nodule(6 cm in diameter)and extensive adhesion of infrahyoid muscles(resulted from a previous injection therapy).The operating time was significantly longer in the Endoscopic Group(100.4?26.6 min)than in the Open Group(73.5?14.5 min)(t=5.627;P=0.000).The postoperative drainage volume in the Endoscopic Group(66.7?24.9 ml)was significantly more than that in the Open Group(13.3?6.4 ml)(t=14.403,P=0.000).The postoperative hospital stay was significantly longer in the Endoscopic Group(4.3?1.1 d)than in the Open Group(3.6?0.9 d)(t=2.886;P=0.005).The Endoscopic Group had significant higher hospital costs(11 572?1675.1 yuan)than the Open Group(5015.9?1211.0 yuan)(t=19.058;P=0.000).And a satisfactory cosmetic result was achieved in significantly more patients in the Endoscopic Group(22/24 cases)than in the Open Group(34/51 cases)(?2=7.235;P=0.007).There was no significant difference in intraoperative blood loss between the Endoscopic Group(22.5?15.3 ml)and the Open Group(18.3?7.5 ml)(t=1.273;P=0.207),and in consumption of analgesics between the Endoscopic Group(9/24 cases)and the Open Group(21/51 cases)(?2=0.028;P=0.867),respectively.No severe complications were encountered,such as massive hemorrhage,injuries of the recurrent or superior laryngeal nerve,or parathyroid gland injury.During a follow-up for 6 months,none of the patients was found recurrence after surgery.Conclusions Both breast approach endoscopic thyroidectomy and conventional open thyroidectomy are safe and effective.The former gives better cosmetic outcomes but slower recovery and high hospital costs compared to the latter.

Shu-Xue-Ning (SXN) injection was used as study subject in order to explore the feasibility of pharmacodynamics experiment of Phase 0 clinical trial in Chinese materia medica (CMM).This paper tried to establish key-technique standards which fit to the evaluation on CMM phase 0 (early) clinical evaluations.According to the established research methods,this research selected volunteers and assured low dose SXN injection inside their body.And then,serum before and after medication were collected for the HAEC in vitro experiment.Blood sample of the clinical dosage was used as control to verify the tendency consistency of pharmacodynamics in low dose and clinical dose.The results showed that in the H2O2 inducing HAEC damage experiment,low dose SXN injection can affect the cell proliferation,protect the shape of cells,reduce the release of ion owing to cell damages and influence the secretion in cells.Complete-sequence RNA gave differential multiterm expression before and after the low dose.It was concluded that compared with the clinical group,low dose medication had similar metabolic tendency.The pharmacodynamics experiment of phase 0 CMM clinical trial is feasible.

Purpose:To evaluate the efficacy of treating malignant pleural effusion with S 311 anticancer vaccine by intrapleural injection.Methods:62 cases with malignant pleural effusion,after drainage, S 311 anticancer vaccine 0.16 mg was injected into the pleural cavity in therapy group (T),and cisplatine 40 mg/m 2 in control group (C).The treatment was repeated after a week , then the efficacy, quality of life, survival rate and toxicities was evaluated.Results:The response rate was 90.6% in T group and 60.0% in C group. There was statistical difference between the two groups ( P

Objective This study was designed to investigate the expression and clinical significance of transcription factor E2F-1 and apoptosis-off gene Bcl-2 in human colorectal carcinoma.Methods Immunohistochemistry is used to detect the expression of E2F-1、Bcl-2 proteins in 60 cases of human colorectal carcinoma tissues and their corresponding normal mucosa.Results The positive expression rate of E2F in cancer tissues is 56.7%,while the positive expression rate of E2F in corresponding normal mucosa is 6.7%,so the comparison between two tissues is significant (P

Objective To survey the epidemiological situation of asthma in remission stage in Liaoning province,and provide evidence for preventing and treating asthma.Methods 800 patients of asthma in the remission stage were investigated through the questionnaire investigation.Results Onset age of asthma in Liaoning province was 30～40 years old.The sex ratio between male and female was 1 ∶ 1.34.The number of staff was the highest (25.75％).Most of the course of asthma was 1～5 years (33.50％).The number of patients who often receive treatments was 59 (7.38％)and the number of patients with allergy history was 531 (66.38％).Conclusion Prevention,management and treatment of asthma should be strengthened.

Laparoscopic pancreas- and spleen-preserving splenic hilar lymph nodes dissection is still difficult to accomplish,which restrains its application in total gastrectomy for advanced proximal gastric cancer.Based on our anatomical understanding of pre- and retropancreatic spaces,features of splenic vessels and distribution of perigastric lymph nodes,we combined the characteristics of laparoscopic surgery and developed a novel technique for laparoscopic pancreas- and spleen-preserving splenic hilar lymph nodes dissection through retropancreatic space.The key lies in mobilization of the splenic pedicle through retropancreatic space,dissection of peri-vascular lymph nodes in sequence of trunk-to-branch,in-sheath vascularization of the splenic vessels.From August 2009 to December 2010,this technique was performed on 6 patients in Nanfang hospital.The initial results suggested that this technique could be safe and feasible for skillful surgeons.Further studies on the application of this technique in total gastrectomy for advanced proximal gastric cancer would be needed.

Correct implementation of laparoscopic total gastrectomy with D2 lymph node dissection depends on the understanding of anatomical features of peripancreatic space, the landmark of pancreas and blood vessels, and the diverse perigastric vascular anatomy and standardized surgical procedures designed according to the regional distribution of lymph nodes.From September 2006 to November 2009, laparoscopic total gastrectomy with D2 lymph node dissection surgery were completed in 12 cases in the Nanfang Hospital. A reasonable anatomy method and a simple, effective surgical procedure of laparoscopic D2 lymph node dissection were introduced.

Aim To observe the effects of borneol on the pharmacokinetics of carbamazepine(CBZ) and 10,11-epoxide carbamazepine(ECBZ) in rabbits.Methods After ig administration of bornol and CBZ,the CBZ and ECBZ were determined with HPLC,then the pharmacokinetic parameters were obtained with 3P87 program on computer.Results In the CBZ-borneol combination group,the pharmacokinetic parameters of CBZ,T_(12(ka)),T_(peak) and AUC were increased,while Ka and CL were decreased.The parameters of ECBZ,T_(12(ke)) and T_(peak) were increased,while Ke was decreased.The ratio of CSF to plasma of ECBZ at the time of 0.5,1,2 hour after ig was increased.Conclusion Borneol significantly improved the bioavailability of CBZ,inhibited the metabolism of CBZ,and enhanced the ECBZ passing through blood brain barrier.

In recent years,laparoscopic total gastrectomy (LTG) with lymphadenectomy is increasingly utilized for the management of gastric cancer located in the middle or upper third of the stomach.However,esophagojejunostomy is the key technical difficulty in operation.Compared with conventional extracorporeal esophagojejunostomy via mini-laparotomy,pioneers are attempting to perform intracorporeal anastomosis in order to gain better manipulation and minimally invasive benefits,as well as reducing the difficulties in digestive tract reconstruction.

Lung distension belongs to chronic obstructive pulmonary disease (COPD) in modern medicine.In recent years,its disease incidence and mortality have increased year by year.Supported by the traditional Chinese medicine (TCM) standardization of the State Administration of TCM project-TCM preventive treatment practice guidelines-prevention of lung distension recrudescence,the first draft of the TCM Preventive Treatment Practice Guideline on Prevention of Lung Distension Recrudescence was formulated on the basis of preventive treatment theory,evidences from both ancient and modern literatures,and through the Delphi method as well as expert consensus conference.And then,peer review comments were collected,which laid the foundation for the further improvement of this guideline.This guideline was aimed to achieve the industry consensus,to improve the quality of life (QoL) in patients of the stable period,to reduce the economic burden of patients,as well as to improve both the theoretical connotation and practical value of preventive treatment in TCM.