AIM： To give some information for rational administration of oral antiepileptic drugs to epileptic patients in clinic METHODS： The serum concentrations of oral phenytoin sodium， phenobarbital and carbamazepine were determined in 88,63 and 63 epileptic patients（ total 214 times） by fluorescence polarization immunoassay， respectively The individualized drugs administration schemes were provided RESULTS： The sensitivity to the three kinds of antiepileptic drugs varied in different patients CONCLUSIONS： The administration of oral antiepileptic drugs to epileptic patients must be based on the data of drug concentration in serum We must comprehensively consider the other factors

Objective: To investigate the etiologic and epidemiologic features of an infectious diarrhea outbreak in a boarding school in Fuyang city, Anhui province. Methods: Traceability hypothesis of this study was tested according to the epidemiological characteristics of the cases. Feces, anal swabs, water samples and food residues related to the patients and chefs were collected for pathogen isolation and detection. Biochemical identification, virulence gene detection, drug susceptibility test, PFGE and multilocus sequence typing were performed. Results: The incidence rate (3.41%) of different dormitory buildings within the water supply area by shallow wells was higher than that (0.98%) of the deep wells, with statistical significance (χ²=17.215, P<0.001). Sixteen strains belonged to the Shigella Sonneri family were isolated from the patient’s samples, and all carrying the ipaH gene. Seven strains belonged to sen and ial genes. Set1 gene that did not appear in all the 16 strains were highly resistant to ampicillin, tetracycline, compound xinnomine, cefazoline, cefotaxime, gentamicin, naphthidinic acid and streptomycin, including 9 strains to doxycycline. The pulse field pattern of the 16 strains of Shigella sonneri appeared the same, with the ST type as ST152. Conclusion When combined data from the etiological and epidemiological investigation, it was confirmed that Shigella sonneri was the pathogen of this outbreak, and water from the shallow wells might be responsible for the source of infection.