Objective To evaluate the physical activity status of the advanced aged adults and determine the influence of long-term physical activities on the physical function and health of the advanced aged adults. Methods A survey was carried out from March, 2004 to September, 2004, among those advanced aged intellectuals or cadres taken care chronically by the Patient Clinic for Senior Cadre in PUMC Hospital. Physical activity was assessed using the modified leisure-time physical activity questionnaire. Results There were 259 participants, aged from 80 to 94 (83.92?3.41)years. 85.3%(221/259 cases)took physical activities almost every day for more than eleven years, and 21.7% of them (48/221 case)even stuck to it from their youth. Among these 221 participants, 34.4% took≥ 60 min per day of physical activities,and 51.0% ≥30 min per day. The group that took ≥ 60 min per day held a lower proportion than the group that took ≥ 30 min per day to suffer from agrypnia, debilitation, somasthenia and anorexy (by 20.3%, 24.0%, 21.7% and 13.1%,respectively(P

Genome-wide association studies use high-throughput genotyping technologies to scan thousands of nucleotides of the entire human genome to investigate the relation of clinical conditions and measurable phenotypes.Bladder cancer is the result of the interaction between genetic variants and environmental factors.Many progresses have been acquired from genome-wide association studies.New genetic regions have been discovered to provide us new strategies for the etiology investigation of bladder cancer.

Objective: To investigate the symptoms of depression and anxiety and their influencing factors among manufacturing workers in a district of Beijing Municipality, so as to provide insights into prevention and intervention of depression and anxiety among workers in this industry. Methods: Frontline workers from 15 manufacturing enterprises including large, medium, and small/micro sizes were selected using the stratified random sampling method. Demographic and occupational information were investigated using the Chinese National Occupational Health Literacy Monitoring Questionnaire among Key Populations. The symptoms of depression and anxiety were assessed by the 9-item Patient Health Questionnaire and the Generalized Anxiety Disorder Scale, respectively. The influencing factors for depression and anxiety symptoms were analyzed using a multivariable logistic regression model. Results: A total of 759 questionnaires were allocated and 748 valid questionnaires were recovered, with an effective recovery rate of 98.55%. The respondents included 372 people (49.73%) from 3 large enterprises, 167 people (22.33%) from 3 medium enterprises, and 209 people (27.94%) from 9 small/micro enterprises. There were 584 males, accounting for 78.07%. The median age was 39 (interquartile range, 11.00) years, and the median duration of employment was 8.50 (interquartile range, 11.00) years. Depression and anxiety symptoms were detected in 175 and 68 cases, with the detection rates were 23.40% and 9.09%, respectively. Multivariable logistic regression analysis showed that the educational level (junior high school, OR=0.305, 95%CI: 0.129-0.723), weekly working duration (≥55 h, OR=1.727, 95%CI: 1.026-2.906) and sleep disorders (OR=3.062, 95%CI: 2.127-4.407) were influencing factors for depression symptoms; educational level (junior high school, OR=0.196, 95%CI: 0.074-0.523; high school/vocational high school/technical secondary school, OR=0.171, 95%CI: 0.064-0.452; junior college and above, OR=0.187, 95%CI: 0.066-0.527), work shift (night shift, OR=2.369, 95%CI: 1.344-4.177) and sleep disorders (OR=5.411, 95%CI: 3.076-9.519) were influencing factors for anxiety symptoms. Conclusion The symptoms of depression and anxiety among manufacturing workers are mainly affected by educational level, weekly working duration, work shift and sleep disorders.

Objective: To investigate the awareness of occupational health knowledge among workers in key industries in a district of Beijing Municipality, so as to provide the evidence for formulating occupational health knowledge propaganda and interventions. Methods: A total of 1 562 workers were randomly sampled using a stratified cluster random sampling method from 10 large-size, medium-sized, small-sized/micro enterprises in the second industry in a district of Beijing Municipality. Participants' basic characteristics and awareness of occupational health knowledge were collected using the Chinese National Occupational Health Literacy Monitoring Questionnaire Among Key Populations, and the awareness of occupational health knowledge was analyzed. Results: Totally 1 562 questionnaires were allocated, and 1 479 valid questionnaires were recovered, with an effective recovery rate of 94.69%. There were 821 respondents from large-sized enterprises (55.51%), 307 from medium-sized enterprises (20.76%) and 351 from small-sized/micro enterprises (23.73%), and 513 respondents from 4 furniture manufactures (34.69%) and 966 from 6 automobile manufacturers (65.31%). The respondents included 1 148 men (77.62%). The awareness of occupational health knowledge was 80.53%, with 79.42% in men and 84.73% in women, and was 67.53%, 85.05%, 80.08% and 78.22% among workers with educational levels of primary school and below, junior high school, high school/vocational high school/technical secondary school and junior college and above, 76.05%, 81.67%, 81.37% and 80.86% among workers at ages of 18 to 29, 30 to 39, 40 to 49 and 50 to 69 years, 78.79%, 81.65%, 79.17% and 83.96% among workers with working duration of 3 years or less, >3 to 6 years, >6 to 10 years and longer than 10 years, and 93.37% and 74.90% among workers from furniture and automobile manufacturers, respectively. There were gender-, educational level-, age-, working duration- and industry-specific awareness rates of occupational health knowledge among workers (all P<0.05). Conclusions The awareness of occupational health knowledge among workers in key industries from a district of Beijing Municipality fail to reach the target set in the 14th Five-Year Plan for Occupational Health Control in China and Beijing Municipality. Workers' gender, educational level, age, working duration and industry may affect the awareness of occupational health knowledge, and targeted health education requires to be reinforced.

Objective To summarize the experience of modified Nuss procedure with thoracoscope for the correction of pectus excavatum in children. Methods Forty-nine pediatric pectus excavatum were treated by modified Nuss procedure with thoracoscope from August 2006 to July 2008, the age ranged from 3 to 18 years, 36 patients were symmetric pectus excavatum and 13 patients were asymmetric pectus excavatum. Results The operations in all patients were successful. Only 1 case used two bars,other 48 cases used one bar. There were no major complications such as cardiac perforation occurred during the operation. The earlier complication was pneumatothorax in 1 case, and the average blood loss was less than 10 ml. The postoperative hospital length of stay was 6-8 days. All patients had a satisfied deformity correction and no needs of transfusion. Therapeutic results evaluation showed excellent in 43 patients and good in 6 patients. All patients were followed up in 0.5-23.0 months without bars displacement, 1 ease had chronic intermittent pain for 2 months. The bar had been removed in 1 case after operation 23 months who still kept in excellent result. Conclusions Modified Nuss procedure is easy to performed with minimal invasion and satisfied deformity correction. Thoracoscopic visualization facilitates the safety of this technique.

Objective To discuss the clinical application of simplified neonatal critical illness score (sNCTS)in comparison with original neonatal critical illness score(oNCIS)published in 2001.Method A total of 705 neonates referred to neonate ICU(NICU)from 1 st January 2007 to 31th December 2009 were prospectively studied with control.The patients were scored by oNCIS on admission day,3rd,7th days after admission and on the day of discharge or dead.At the first scoring on admission,2 items of the PaO2 and pH were excluded from oNCIS's 10 items,and the remaining 8 items were used.Three items of plasma sodium,potassium and creatinine or BUN were scored out from 8 items and the still remained 5 items were used for the subsequent 3 scorings.The remaining 8 and 5 items were used as a simplified neonatal critical illness score.The simplified NCIS was evaluated by comparing the patients'condition that was assessed by the originat NCIS.The consistency rate between oNCIS and sNCIS should be over 80%.Results There were 8 items were used to evaluate the severity of disease on admission, and the consistence rate was 86.7%with the original NCIS.The 5 items selected from the original NCIS were used on the 3rd,the 7th days and the day of discharge or death.the consistence rate with original NCIS were 86.6%to 95.7%.A close correlation existed between the original NCIS and simplified NCIS(P<0.01).There were significant differences in mortality rates of the non-serious,serious and extremely serious groups between original NCIS and simplifled NCIS used for the first and the last seorings(P<0.01).Within a cohort of neonates with the same general condition,the assessments of mortality rates were not significantly different between these two methods (P>0.05).Conclusions Compared with the original NCIS.the simplified NCIS is consistent to a large extent in disease assessment,which is a concise way to evaluate the critical ill neonates objectively and can be easily applied to clinical practice.

【Objective】To search an effective therapy for total alopecia (TA) and universal alopecia (UA) .【Methods】Nineteen cases of TA and twelve of UA were treated with combined therapy: irradiation with high-performanceelectromagnetic wave equipment, acupoint injection on Zusanli point (ST36) , external application of Yifa Tincture B andhormones, internal medication of hormones and washing with Xianglian solution.【Results】Among 31 cases of TA andUA, 17 were cured, 6 were markedly effective, 5 effective and 3 ineffective, the total effective rate being 90.3%.【Conclusion】Combined treatment with Chinese and western medicine has a certain effect for TA and UA.

Objective To provide references for the plan-making of mental intervention on new recruits through the exploration of the comprehensive psychological behavior training influences on psychological stress and health and relevant factors.Methods 436 new recruits in training period were divided into comprehensive psychological behavior training group (intervention group) and non intervention group (control group).By randomly selected 2 (intervention group,control group) × 2 (Before training and after training) matching design,the questionnaire survey was carried out using stress-reaction questionnaire (SRQ),symptom checklist 90 (SCL-90),eysenck personality questionnaire(EPQ),trait coping style questionaire(TCSQ) at the 15th day and 75th day.t-test between group and matched t-test within group and multiple stepwise regression analysis were carried out.Results (1) The SCL-90 total point of new recruits in intervention group (125.26±36.52)and control group(124.92± 34.79) before the training and the difference of SRQ and TCSQ factor scores had no statistical significance(P＞ 0.05).The difference after the comprehensive psychological behavior training had no statistical significance (P＞ 0.05) as the total points of SCL-90 of intervention group(125.63±36.74) and other factors' score were compared with before.Except for the somatization and force,the total points of SCL-90 (131.21 ± 39.98)and other factor scores of the control group were all higher than what they were in the early period of the training significantly (P＜ 0.01 or P＜0.05).In the later period of group training,from the parallel controlled study among groups we found that except for the somatization and force,the total points of SCL-90 and other factor scores of the control group are all lower than the control group (P＜0.0 or P＜0.05).(2)The total points of intervention group's SCL-90 and SRQ had significant positive correlation with negative coping and stability(r=0.313-0.698,P＜0.01) while it had negative correlation with introversion and extroversion(r=-0.293--0.207,P＜0.01) as well as dissimulation at the later period of group training,however,it did not have significant correlation with positive coping method (P＞0.05).(3) The regression analysis showed that factors significantly affected the total score of SCL-90 respectively was:SRQ total score,negative coping method,stability,introversion-extroversion and psychoticism (P＜ 0.01).Five variables'coefficient of determination R 2 =0.665,F=247.82,P＜ 0.01.Conclusion The comprehensive psychological behavior training could reduce the over psychological stress of new recruits,promote their positive coping attitude and protecting their psychological health.Coping method and personality characteristics are important mediating variable between new recruits' psychological stress and mental health.

Objective To summarize the clinical experience of surgical treatment for complete atrioventricular septal defect in infants.Methods From December 2013 to June 2004,56 patients aged from 53 days to 12 months with complete atrioventricular septal defect were undergone operations.All patients were diagnosed by 2D-echocardiography,and 18 patients underwent cardiovascular computed angiography (CTA).Rastelli type A had 44 cases,type B 3 cases,and type C 9 cases.The single pericardium patch repair was used for 37 cases,the two-patch repair for 3 cases,and the modified single-patch repair for 16 cases.The time of mechanical ventilation was 26 to 172 hours,and the time of staying at Intensive Care Unit (ICU) was 3 to 19 days.Results There were 5 early deaths caused by severe low cardiac output in 2 cases,renal failure in 2 cases,and severe pulmonary inflammation in 1 case.One late death was due to severe mitral regurgitation with pneumonia and heart failure.The operative mortality was 10.7％.A total of 47 patients was followed-up for 3 months to 5 years after surgery and their heart function was satisfactory.Conclusions The operation should be done between 6 months and 1 year when the diagnosis of complete atrioventricular septal defect (CAVSD) is clear.Its early surgical intervention is satisfactory.The result of surgical treatment for CAVSD depends on both probing intracardiac anatomy carefully and complete correction of associated cardiac abnormalities.

Objective To investigate the prevalence rate and the related risk factors of post traumatic stress disorder (PTSD) in rescue troops one year after Wenchuan earthquake as science proofs of mental interven-tion. Methods 1176 officers/soldiers from rescue troops were tested with the questionnaire composed by General state of health questionnaire, PTSD Checklist-Civilian Version (PCL-C), Symptom Checklist-90 (SCL-90), simple coping style questionnaire (SCSQ) and Eysenck Personality Questionnaire (EPQ). Students't test and correlation analysis were used to study the risk factors. Results One year after Wenehuan earthquake,the prevalence rate of PTSD was 3.45%. Compared with the norms of Chinese serviceman, some evaluative indexes' scores, including somatization(1.43±0.57),exterior(12.50±3.79)/interior and positive response factors(2.05±0.71), were higher(P<0.05), at the same time some evaluative indexes' scores, such as anxiety,depression,nervousness and negative response factor, were obviously lower(P<0.01). Correlation analysis showed total score of PLC-C was positively correlated with somatization, anxiety, depression and negative response factors, separately (P<0.01),but negatively correlated with exterior/interior and positive response factors, separately (P<0.01).Conclusion The psychological status of the earthquake-rescuers is basically normal one year after Wenchuan earthquake. The younger soldiers with less education,who have nervous,introversive character,are the emphasis crowd.