1.Effect of sulfonylurea compounds on expression of sulfonylurea receptor 2 in myocardium of diabetic Goto-Kakizaki rats
Academic Journal of Second Military Medical University 2000;0(07):-
0.05).Conclusion:The diabetes itself does not affect the sulfonylurea receptor(SUR2)expression in myocardial tissues.Sulfonylureas at treatment dosage have no effect on receptor expression of SUR2.
2.Influence of sulfonylureas on cardiovascular system:progress in basic research and clinical research
Academic Journal of Second Military Medical University 2001;0(09):-
Previous studies have showed that sulfonylureas possess a bidirectional effect on cardiovascular system:they can raise the coronary artery tone,aggravate ischemic injury to the cardiovascular tissues,and accelerate cardiac hypertrophy through closing cardiovascular ATP-sensitive K+ channels;meanwhile,they can also regulate glucolipid metabolism,modulate inflammatory reaction and inhibit atherosclerosis through activating peroxisome proliferator-activated receptors.Clinical-epidemiological study showed different opinions on whether sulfonylureas can increase the mortality of patients with cardiovascular diseases.
3.Study of The Effect on Islets Cultured In vitro and STZ-induced Diabetic Rats In vivo of EGF-like Domain of Betacellulin
Hong LI ; Weibin ZHOU ; Fengying LI ; Yanyun GU ; Jingyan TIAN ; Lei QIAN ; Di ZHANG ; Wenzhong ZHOU ; Guoting WU ; Tianhong LUO ; Guo LI ; Min LUO
Progress in Biochemistry and Biophysics 2006;0(12):-
Betacellulin (BTC) is one of "islets regeneration factors" which received more and more attention these years. BTCe is the C-terminal 50-residue region of mature BTC protein and can bind with erbB-1?erbB-4 receptor. It has the same mitogenic activity on cells as the whole section. BTC and BTCe can improve the level of glucose-stimulated insulin secretion (GSIS) during islets culture in vitro though they had no effect on the acute insulin secretion. BTCe also effectively ameliorated the hyperglycemia of STZ-induced diabetic rats by a single plasmid injection into muscle of rats. It is supposed that BTCe promote the proliferation of PDX-1 positive cells or repair some signal transduction pathway. Perhaps the latter is more important.