1.The options of surgery and laryngeal preservation for hypopharyngeal cancer patients more than 65 years old.
Qin WANG ; Yehai LIU ; Guoqin HU ; Kaile WU ; Chaobing GAO ; Yi ZHAO
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(4):334-338
OBJECTIVE:
To study the effectiveness of preserving laryngeal function for senile hypopharyngeal cancer patientsolder than 65.
METHOD:
The clinical data of 58 surgery cases of senile hypopharyngeal cancer patients more than 65 years old were colleted and analyzed. Thirty-one cases preserved the laryngeal function, while the rest did not. Perfect preoperative preparation was done before surgery. Surgical resection specimens were sent to frozen-section examination. When the negative incisal margin was confirmed, the defect was repaired by the appilication of local stitching, ribbon muscle flap, major myocutaneous flaps, split thickness skin and replacement of esophagus by stomach. Radical radiotherapy was used after surgery. Survival rate was calculated by the Kaplan-Meier method. Chi-square test was used to compare complications of the two groups.
RESULT:
The 3 years and 5 years survival rate for all cases were 48.3% (28/58) and 27.6% (16/58), respectively. For patients with laryngeal function preservation, the 3 years and 5 years survival rate were 51.6% (16/31), 29.0% (9/31), respectively. For cases without laryngeal function preservation, the 3 years survival rate and 5 years survival rate were 44.4% (12/ 27), 25.9% (7/27), respectively. The result showed no obvious difference in survival rate between two groups (P > 0.05). Surgery complication rate were 45.2% (14/31) and 40.7% (11/27), without obvious differences between the two groups (P > 0.05).
CONCLUSION
It is feasible for senile hypopharyngeal cancer patients to choose suitable operation based on their physical conditions and the tumor extension. The key issues include well perioperative treatment management, correct indications grasp, and intraoperative repair skills improvement.
Aged
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Humans
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Hypopharyngeal Neoplasms
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surgery
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Larynx
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Survival Rate
2.Relationship between hypertriglyceridemic-waist phenotype and clustering of cardiovascular risk factors in adolescents
Chunming MA ; Xiaoli LIU ; Guoqin GAO ; Rui WANG ; Fuzai YIN ; Yue LIU ; Gailing HAN ; Cuijuan WANG ; Na LU ; Qiang LU
Chinese Journal of Endocrinology and Metabolism 2015;(2):95-98
Objective The aim of the study was to explore the relationship between hypertriglyceridemic-waist(HTWC) phenotype and clustering of cardiovascular risk factors in adolescents. Methods A cross-sectional study was conducted in 3 136 Han adolescents aged 13-17 years in Qinhuangdao. The HTWC phenotype was defined as serum triglyceride concentrations ≥1. 47 mmol/ L and waist circumference ≥90 th percentile for age and sex. Results The prevalence of HTWC phenotype was 3. 3% . The prevalence of clustering of cardiovascular risk factors was 0. 4%in adolescents with normal waist circumference and serum triglyceride and 14. 7% in adolescents with HTWC phenotype. After adjustment for sex, age, body mass index, and family history of diabetes and hypertension, the prevalence of clustering of cardiovascular risk factors in adolescents with HTWC phenotype was 9. 286 fold(95% CI 3. 161-27. 282, P<0. 01) of that in adolescents with normal waist circumference and triglyceride. Conclusion There was a significant correlation between HTWC phenotype and clustering of cardiovascular risk factors, suggesting that this phenotype may be applied as a simple marker for identifying adolescents with clustering of cardiovascular risk factors.
3.A case of cardiac amyloidosis misdiagnosed as hypertrophic cardiomyopathy.
Xiurui MA ; Zhulin ZHANG ; Lizhen ZHANG ; Guoqin WANG ; Wenyan LAN ; Jie CHEN ; Jingping WANG ; Tianliang LI ; Jiang WU ; Lifang GAO ; Bao LI
Chinese Journal of Cardiology 2015;43(10):909-910
4.Value of T2WI histogram analysis in differential diagnosis of glioblastoma and solitary metastatic brain tumor
Guoqin ZHANG ; Xin CHEN ; Sijing ZHANG ; Cuihua GAO ; Xiuhang RUAN ; Xinqing JIANG ; Xinhua WEI
Chinese Journal of Medical Imaging Technology 2017;33(12):1779-1783
Objective To investigate the value of T2WI histogram analysis in differential diagnosis of glioblastoma multiform (GBM) from solitary metastasis.Methods Data of 103 patients with pathologically confirmed GBM (GBM group,n=57) and solitary brain metastasis (solitary brain metastasis group,n =46) were retrospectively reviewed.All patients underwent conventional MR scanning,including axial T1WI,T2WI,FLAIR and contrast-enhanced T1WI before surgery.The histogram metrics,including mean,standard deviation (SD),median,kurtosis and skewness were calculated from ROI,which were manually placed on the maximal section of the solid part of tumors on T2WI by using Image J software.ROCs were generated to evaluate differential diagnostic performance of the histogram metrics with significant difference between both groups.Results The values of mean,SD and median were significantly higher in GMB group than those in solitary brain metastasis group (P<0.05).The areas under ROC curve of mean,SD and median was 0.772 (95% CI [0.681,0.862],P<0.001),0.719 (95% CI [0.616,0.822],P<0.001) and 0.767 (95% CI [0.674,0.860],P<0.001),respectively;and the diagnosis cutoff value of mean,SD and median was 509.575,58.844 and 550.500,respectively.The sensitivity of the three parameters was 0.719,0.702 and 0.719,and the specificity was 0.783,0.652,and 0.826,respectively.Conclusion The value of mean,SD and median of T2WI histogram analysis can be helpful to differentiating GBM and solitary brain metastasis,of which the mean value is the best for differential diagnosis.
5.Application of VR and AR integrated teaching system in stomatology general medical education of clinical medicine students
Haochen GAO ; Xu HAN ; Qiang ZHU ; Qingjun JIANG ; Guoqin LIU ; Jiajun ZHOU ; Xing ZHENG ; Jianjin WU
Chinese Journal of Medical Education Research 2021;20(11):1279-1282
Objective:To investigate the application and effect of the virtual reality (VR) combined with the augmented reality (AR) integrated teaching system in stomatology general medical education of clinical medicine students.Methods:A total of 160 undergraduates from the five-year clinical medicine Batch 2015 of Naval Medical University were randomly divided into VR+AR group and traditional group, with 80 students in each group. A comparative analysis was made on the previous and teaching achievements of the two groups of students, and a questionnaire survey was conducted after the completion of the class. Epidata 3.0 was used to input questionnaire data, and SPSS 23.0 software was used to carry out t test, chi-square test and Fisher precision test. Results:There was no statistical difference in written test scores between the VR+AR group and the traditional group [(52.65±3.76) vs. (51.90±3.46), P=0.516], but the VR+AR group was significantly higher than the traditional group in case analysis scores [(35.85±2.56) vs. (31.40±2.96), P < 0.001] and overall performance [(88.50±4.95) vs. (83.30±4.86), P= 0.002]. The questionnaire survey results showed that the scores of "teaching mode" [(92.30±6.90) vs. (85.20±7.30), P<0.001], "teaching method" [(91.70±5.90) vs. (86.00±6.70), P=0.012] and "teaching improvement" [(90.70± 8.70) vs. (82.30±8.40), P<0.001] in VR + AR group were significantly higher than those in the traditional teaching group. Conclusion:The VR combined with AR integrated teaching system can significantly improve teaching performance and teaching quality, and is convenient for teaching demonstrations and simulation operations in small oral spaces, and is especially suitable for oral general medical education for clinical medicine.
6. Surgical management of elderly patients with medial wall pyriform sinus cancer
Qin WANG ; Yehai LIU ; Guoqin HU ; Kaile WU ; Busheng TONG ; Chaobing GAO ; Yi ZHAO
Chinese Journal of Oncology 2017;39(12):931-936
Objective:
To investigate the clinical efficacy of preoperative-, postoperative-radiotherapy and surgery for preserving laryngeal function in patient over 70 years of age with medial wall pyriform sinus cancer.
Methods:
Clinical data of 48 patients over 70 years of age with medial wall pyriform sinus cancer who received surgical treatment from January 2001 to December 2010 were retrospectively analyzed. Among them, 21 cases were given preoperative radiotherapy and surgery (R+ S). The radiation therapy dose was 45 Gy. And 14 cases′ larynx is preserved. In addition, 27 cases were given postoperative radiotherapy and surgery (S+ R). The radiation therapy dose was 65 Gy. And 10 cases had preserved laryngeal function. Survival rates were analyzed by the Kaplan-Meier method. Chi-square test was used to compare complications between two groups.
Results:
The larynx preservation rate in R+ S group [66.7% (14/21)] was significantly higher than that in S+ R group [37.0% (10/27),
7. Inhibition of CD4+T cell infiltration by interleukin-10 competent B cells in periodontitis tissues
Guoqin CAO ; Xu ZHANG ; Yan ZHAO ; Siqi ZHAO ; Guocui DONG ; Qiuxiang GAO ; Zuomin WANG ; Jiang LIN
Chinese Journal of Stomatology 2019;54(8):553-560
Objective:
To study the immune regulation function of high expressing interleukin-10 (IL-10) in B cells on CD4+T-cells in periodontitis mouse model.
Methods:
Twenty-four 7-weeks-old female C57BL/6 mice were randomly and equally assigned into 4 groups: the healthy control group (HC group,