Objective To evaluate the effectiveness and feasibility of web-based lifestyle Or behavior intervention on Chinese urban adults.Methods Six hundred and eighty-one adult subjects were rand omly assigned to the intervention group (n=341) or the control group (n=340).The intervention group was encouraged to visit a specified interactive web site at 1east once a month to submit self-report health diaries.and provided with individualized health promotion instructions and tailored counseling at the chat room or through email.The control group received routine medical services.The primary outcomes were changes in cigarette smoking,alcohol consumption,fruit or vegetable intake,and physical exercise duration at 6 month from baseline.Intention-to-treat method was used for data analysis.Results At 6 month,smoking cessation rate was 23.6% in intervention group and 4.6% in control group (X2=22.4,P<0.05),and daily alcohol consumption decreased by 28.6 g in intervention group compared to 6.1 g in control group (t=14.9.P<0.05).There Was no significant change in physical exercise duration for those with sub-optimal physical activities between the two groups.In contrast to the control group.mean systolic blood pressure,fasting blood glucose,and body mass index of the hypertensive,diabetic,or overweight/obese subjects in the intervention group showed statistically significant decrease.There was no significant change in serum cholesterol level for the participants with hypercholestemlemia in both groups.The attrition rate was 6.7% in the intervention group.Conclusion Web-based health management services may be helpful in promoting healthy lifestyle and behavior and enhancing the care of chronic conditions including hypertension,diabetes,overweight and obese.

Extracorporeal membrane oxygenation (ECMO) is the last resort for the severe and reversible respiratory or cardiac diseases in neonates and has been increasingly used in China.With the advancement of medical management and surgical techniques and the accumulation of ECMO treatment experience, the overall survival rate has increased.However, neurological complications and long-term poor outcomes is still common.Therefore, the monitoring and evaluation of neurological functions in the progress of ECMO treatment make sense.The combination of multiple monitoring methods can minimize neurological damage and improve long-term prognosis.In this review, the indications, advantages and disadvantages, timing and frequency, duration and neurodevelopmental outcome evaluation of monitoring techniques commonly used in neonatal ECMO therapy were reviewed.

Objective:To investigate the effect of miR-23b on the malignant phenotype and the sensitivity of lenvatinib in human hepatocellular carcinoma cells.Methods:Human hepatocellular carcinoma cell line HepG2, SMMC-7721 and QGY-7703 were transfected with miR-23b mimic and its control, respectively. CCK-8 and EdU assay were used to detect cell proliferation. Transwell assay were used to detect changes in cell migration and invasion. Tube formation assay were used to detect vasculogenic mimicry formation. The comparison of the mean between groups was analyzed by t-test.Results:CCK-8 results showed that the A values ??of human hepatocellular carcinoma cell line HepG2 and SMMC-7721 in the miR-23b mimic group were 0.325 ± 0.011 and 0.537 ± 0.026, respectively, which were significantly lower than the control group 0.430±0.017 and 0.752 ± 0.051 ( P < 0.05). Transwell assay result showed that the number of cell migration of human hepatocellular carcinoma cell line HepG2 and SMMC-7721 in the miR-23b mimic group was (517.220 ± 32.873) and (242.327 ± 20.793), respectively, which were significantly lower than that of the control group (724.130 ± 15.142) and (424.432 ± 27.212) ( P < 0.01). Simultaneously, the number of cell invasions in the miR-23b mimic group were (55.671 ± 7.514) and (64.670 ± 6.011), respectively, which were significantly lower than those in the control group (124.320 ± 11.782) and (156.204 ± 12.501) ( P < 0.01). Tube formation assay showed that the number of tube forming branches of hepatocellular carcinoma cell line QGY-7703 and SMMC-7721 in the miR-23b mimic group was (489.824 ± 42.035) and (435.201 ± 44.143), respectively, which were significantly lower than that of the control group (878.620 ± 31.618) and (785.430 ± 38.723) ( P ??< 0.01). In addition, EdU results showed that after miR-23b combined with lenvatinib, the positive rates of EdU staining of hepatocellular carcinoma cell line HepG2 and SMMC-7721 in the miR-23b mimic group were (32.905 ± 1.342)% and (24.811 ± 0.820)%, respectively, which were significantly lower than the control group (52.623 ± 2.441)% and (38.702 ± 1.312)% ( P < 0.05). Conclusion:miR-23b can inhibit the proliferation, migration, invasion and vasculogenic mimicry formation, and enhance the sensitivity of lenvatinib drug in human hepatocellular carcinoma cells.