Objective To evaluate the effects of pantoprazole on patients with upper gastrointestinal bleeding and its safety, as compared with omeprazole. Methods Ninety patients with non variceal upper gastrointestinal bleeding were randomly assigned to two groups. Sixty patients were in the group of pantoprazole, including 24 patients with gastric ulcer, 33 duodenal ulcer and 3 erosive gastritis; 30 patients were in the group of omeprazole, including 9 patients with gastric ulcer, 15 duodenal ulcer and 5 erosive gastritis.Treatment schemes:either pantoprazole or omeprazole 80 mg were added into 250 ml 5% glucose respectively and then infused intravenously. The clinical signs of the patients including the amout of bleeding were observed. Results After the treatment, the symptoms and sings improved significantly in both groups( P 0.05). Both the total effective rate of pantoprazole and omeprazole on upper gastrointestinal bleeding was 96.7%. The rates of side effects were 1.7% in pantoprazole group and 3.4% in omeprazole group. Conclusion Pantoprazole is also an effective and safe drug for the non variceal upper gastrointestinal bleeding.

By using antr-ras P21 mouse monoclonal (MoAb), SCI-Oncogema 1, the authors examined immunohistochemica! staining in pancreatc adeocarcinoma. The percentage of positive staining was 24/43 (558%). Furthermore it was indicated that the positive staining rate of antr-ras P21 MoAb was related to either histopathological grade or clinical stage. Upon statistical analysis of the correlation between the staining of anti-ras P21 and patient prognosis with Kaplan-Meier curve and Log-rant test, the positive staining cases showed comparatively better prognosis than the negative ones. Our study suggests that ras P21 expression may be important in the early stage of pancreatic carcinoma.

With the method of endoscopic ultrasonography (EUS) and Color scale ultrasound, 156 patients with stomach and gallbladder diseases were examined, The features revealed by the EUS and color scale ultrasound for these diseases were compared with the pathological changes. The findings were that:the mean color quantity scale of benign gastric ulcer was higher than that of gastric cancer(p<0.01).The gallbladder stone was two color quantity scales higher than did polypoid lesions of gallbtadder(p<0.01).The color scale ultrasound can improve the clear degree of lesion pictures.The correct rates of diagnosis were no significant differences between color scale ultrasound and grev scale ultrasound.

To observe the protective effect of somatostatin (SS) on gastric mucosa of rats.Methods: Before gastric mucosal lesion were made in rats by pure alcohol, SS was intravenously droppedand anti-SS serum was injected into the vein, and the change of ulcer index and the degree of gastric mu-cosal lesion were observed. Results: Ulcer index of the SS group was much lower than that of the controlgroup (P

The purpose of this study was to investigate clinical feasibility of treatment of pancreatic pseudocyst by endoscopy. We reported here one case of large pancreatic psuedocyst that was treated by endoscopic ultrasonography guided cystogastrostomy.The patient's symptoms resolved on the same day of operation. And one week later, the pancreatic pseudocyst decreased by more than 50% in size. Pancreatic psuedocyst resolved and didn't relapse after 6 months. So endoscopic ultrasonography guided cystogastrostomy is a safe, reliable, effective therapy for pancreatic pseudocyst with few complications.

The purpose of the present study was to assess the diagnostic value of endoscopic ultrasonography(EUS) and ERCP separately and their combination in chronic pancreatitis. There were 262 cases of chronic pancreatitis from January 1993 to May 2001 in our hospital. Among them 60 cases examined by ERCP and EUS were analyzed retrospectively. The constriction and dilatation of main pancreatic duct and pancreatic duct stones were found by EUS. In all, there were 49 patients who diagnosed chronic pancreatitis by EUS and the accuracy rate was 81 7%. On the other hand, there were 52 patients were diagnosed chronic pancreatitis by ERCP and the accuracy rate was 86 7%. There were also 6 patients who diagnosed by ERCP but undiagnosed by EUS, their coincidence rate was 90%. Furthermore, 59 patients were diagnosed by ERCP in combination with EUS and the accuracy rate was 98 3% ( vs sole ERCP or sole EUS respectively, P

The purpose of this study was to evaluate the killing effects of CD/5-FC suicide gene system mediated by adenovirus vector on human pancreatic carcinoma. Recombinant adenoviruses containing cytosine deaminase(CD) gene were constructed by the homologous recombination method in bacteria. The newly recombinated Ad-CD containing green fluorescent protein (GFP) was propagated in 293 cells and purified by cesium chloride gradient centrifugatioa Human pancreatic carcinoma cell line was infected with this virus, then 5-FC was added, and XTT assay was used to estimate relative numbers of viable cells. A heterotopic human pancreatic adenocarcinoma was successfully established in the flank of Balb/c nude mice. Adenoviral liquid containing CD gene was directly injected into xenografts following administration of 5-FC to observe the antitumor effects. Positive clones were selected by using endonuclease to digest the recombinants and the concentration of viral liquid containing CD gene was 2 1011 pfu/ml. It was found that significant cytotoxic activities were possessed by 5-FC for CD gene-transduced pancreatic carcinoma cells, but there was little effect on nontransduced ones. The anticancer effect was seen in vivo in xenografts of nude mice with in situ CD gene transduction. Our conclusian is that CD gene mediated by adenovirus has a high infectivity and is efficient for gene therapy of pancreatic carcinoma. These data demonstrate the therapeutic efficacy of an enzyme prodrug strategy in treatment of experimental pancreatic

Objective To evaluate the usefulness of cytologic examinations in the diagnosis of pancreatic neoplasms using nasopancreatic drainage and pancreatic duct brushing during ERCP.Methods In 47 patients with pancreatic diseases,cytologic examinations of pancreatic duct brushing and nasopancreatic drainage during ERCP were performed.Results The rate of accuracy,sensitivity,and specificity of brush cytologic examination were 70\^4%,65\^2% and 100%,respectively,and that of pancreatic juice cytologic examinations was 45%,8\^3% and 100%,respectively.Conclusion Our results confirm the value,safety,and utility of obtaining cytologic specimens at the time of ERCP for the early diagnosis of pancreatic neoplasms.

The aim of this study was to investigate the mRNA expressions of p53,p16 and p21 in esophagus under duodenoesophageal reflux and gastroesophageal reflux and to discuss the mechanism of reflux leading to esophageal tumorigenesis. Three kinds of model groups [gastroesophageal reflux(G), duodenoesophageal reflux(D) and duodenogastroesophageal reflux(DG)] and a control group(C) were made by operations. All rats were given carcinogen and the mRNA expressions of p53, p16 and p21 were measured by in situ hybridization. The expression of p53 mRNA in all reflux groups was significantly more than that in group C, and in groups D and DG was significantly more than that in group G. The expressions of p16 and p21 gene decreased in all reflux groups and were significantly lower than those in group C, but there was no difference between these reflux groups. It is concluded that reflux of both gastric juice and duodenal contents can promote tumourigenesis in esophagus by changing the expressions of neoplasm inhibiting genes.The effect of duodenal contents is stronger than that of gastric juice.

Objective The clinical efficacy of pancreatic stent in treating chronic pancreatitis was summarized. Methods The stents were applied in 14 patients with chronic pancreatitis and ductal stricture manifested clinically and roentgenographically. Postoperative abdominal pain, changes in appetite, body weight and fat in stools were observed in follow－ ups. Results The stents, 5～ 10F in caliber, were successfully placed in all patients with first attempt. They were followed up for 210 days ( ranging 28～ 520 days ). The early (3 months ) results showed that the pain remitted in 13/14 (92.9％ ) and 11/13 (84.6％ ) of cases respectively. While abdominal pain persisted in 2 cases inspite of the stents. Along with pain remission the appetite and presence of fat in stools improved associated with increase in body weight. The stents drainage maintained for a median to 256 days (ranging 90～ 520 days) Transient hyperamylasemia occurred in 3 cases. Translocation and occlusion of the stent was found in 1 occasion each on the 98 and 520 day respectively. No other serious complication was detected. Conclusion It is assumed that pancreatic stent is effective to treat chronic pancreatitis with ductal stricture.