OBJECTIVETo assess the quality of reporting by randomized controlled trial (RCT) related to dental implants in China during 2000 to 2012 by using the revised Jadad scale and consolidated standards of reporting trials (CONSORT) (2010) statement.

METHODSThe following electronic databases were searched: Chinese Biomedical Literature Database, Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, PubMed, and EMBASE. A total of 19 journals of stomatology in China were also searched manually. The qualities of RCT with dental implant published between 2000 and 2012 were assessed using CONSORT (2010) statement and revised Jadad scale.

RESULTSTwenty-eight RCTs related to dental implants were identified. The quality of reporting in 28 articles was low. The mean revised Jadad score was 1.29 ± 0.71 and the CONSORT (2010) score was 9.75 ± 3.60.

CONCLUSIONThe methodological qualities of the included studies on dental implants are generally low, and reporting quality remain unsatisfactory.

Objective To establish a HPLC method for determination of Peoniflorin in Zhongzi Sanda Pill.Method Kromasil-C18 column(5 ?m,4.6 mm?250 mm) was used.Mobile phase was methanol-water(30:70).The detective wavelength was at 230 nm.The flow rate was 1.0 mL/min.Results There was a good linear relationship between the injection amount 0.11～2.14 ?g and a good peak form for Peoniflorin in Zhongzi Sanda Pill.The average recovery rate was 98.2%(RSD=1.72%,n =6).Conclusion This method is convenient,effective and accurate for the quality control of Peoniflorin in Zhongzi Sanda Pill.

Objective: To study the classification of congenital velopharyngeal insufficiency(CVPⅠ).Methods:30 patients with CVPI were divided into 2 groups.The patients in group I were with submucous cleft palate,those in group Ⅱwere without noticible abnormality.A11 patients received oral examination and 1ateral cephalogram examination. ANS-PNS(1ength of hard palate),PNS-U(velar 1ength),PNS-PPW(pharyngeal depth),SPT(thickness of soft palate),need ratio, elongation and upward angle of soft palate were measured. Results:PNS-U was shorter and PNS-PPW was longer in the patients than in the health controls (P

Objective To estblish a HPLC method for content determination of ferulic acid in compound prescribe Motherwort Herb capusle. Method The column ZORBAXSB-C18 was used with Acetonitrile-0.2% phosphoric acid aqueous solution (12∶88) as mobile phase, and detective wavelength was 274 nm, the flow rate was 1.0 mL/min. Result Within the range of 0.8～13 ?g, ferulic acid presented a fine linear relationship (r =0.999 99, n =6). The average recovery was 103.0% (RSD=0.4%, n=5). Conclusion The method is suitable, accuracy is high and reproducibility is good, recovery is high, and can control the quality of compound prescribe Motherwort Herb capusle.

Objective: To establish an LC-MS/MS method for the determination of 4-( 4-amino-3-fluorophenoxy )-N-methylpyri-dine-2-carboxamide ( AFP-PMA) as a genotoxic impurity in regorafenib. Methods: The content of AFP-PMA was determined by an LC-MS/MS method. A Waters XBridge Shield RP18 column was adopted to separate the samples and the column temperature was 50℃. The mobile phase consisted of 5 mmol·L-1ammonium acetate aqueous (A)-acetonitrile (B) with gradient elution (0~9 min, 5%B→90%B) at a flow rate of 1. 0 ml·min-1. An electrospray ionization source (ESI) was used in a positive-ion and multiple reactions monitoring mode. The ion channel was m/z 262. 2→244. 1. Results:The standard curve was linear within the range of 2. 41-980. 90 ng·ml-1(r=0. 9998) and the limit of quantification was 8. 02 ng·ml-1. The limit of detection was 2. 41 ng·ml-1, which was e-quivalent to 0.000241% for the concentration of regorafenib. The average recovery was 100.95% and RSD was 2.37% (n=9). Conclusion:The method has good specificity, promising accuracy and high sensitivity, which can be used for determining the trace genotoxic impurity AFP-PMA in regorafenib.

Objective To evaluate the intestinal barrier function of the patients by two-sugar absorption test with high performance liquid chromatography (HPLC). Methods Nineteen children with confirmed food hypersensitivity (FH) and 19 normal children were included in this study. The average age was (8.1?1.7) months. After 8-hour fasting, subjects drank test solution (5 g lactulose and 2 g mannitol per 100 ml) at the dose of 2 ml/kg. Five-hour urinary excretion ratio of lactulose/mannitol (L/M) were measured using high performance liquid chromatography (HPLC). The condition of HPLC was as follows: Sugar-PakI column with refractive index detector; Mobile phase: pure deionized water; Flow rate: 0.5 ml/min; temperature of column: 85 ℃. Results HPLC chromatogram of urine sample was stable. The retention time of mannitol and lactulose was 13.86 min and 9.27 min respectively. A significant rise in 5 h urinary L/M excretion ratios was found in children with FH (0.18?0.06) as compared to that of controls (0.05?0.03) (P

Objective:To study the a feasibility of modified pharyngoplasty in the treatment of velopharyngeal insufficiency.Methods:30 cases of velopharyngeal insufficiency were treated with a modified pharyngoplasty followed by speech training.The effects of the treatment were evaluated by blowing test (BT),chinese articulation inteligibility test (CIT) and hypernasality observation(HO).Results:Before and after treatment BT was 1～26 and 8～40,CIT(%) 20～60 and 47～82,HO(cases) 30 and 3,respectively.Conclusions:The modified pharyngoplastic surgery is feasible in the treatment of velophayngeal insufficiency.

This study is to evaluate the curative effect of repairing the flexor tendons defect in the fibroosseous sheath by transferring the near flexor digitorum superficial tendons. Thirty-two cases (39 fingers) with acute flexor tendon defect in Zone I were repaired by transferring the flexor digitorum superficial tendons. Early protected passive motion was advocated postoperatively. All cases were followed up for 11 to 23 months. The outcome of fingers were excellent in 24,good in 12 and fair in 3 by TAM score. The percentage of excellent and good outcome was 92. 3%. Microrepair of fresh flexor tendons defect in Zone II by transferring flexor digitorum superficial tendons combined with early protected passive motion can prevent the adhension of tendons effectively and restore finger function earlier.

Objective To investigate the clinical effect and safety of EEG biofeedback therapy combined with mirtazapine in the treatment of depressive disorder.Methods 124 patients with depressive disorder were selected and randomly divided into the observation group and the control group,62 cases in each group.The control group was given mirtazapine treatment,while the observation group was given EEG biofeedback therapy combined with mirtazapine.All the two groups were treated for 8 weeks.Before and 2,4,8 weeks after treatment,the clinical effects in the two groups were evaluated by Hamilton depression scale (HAMD),Montgomerie depression rating scale (MADRS) and the clinical global impression scale (CGI).The side effects scale(TESS) assessment was used to assess the side effects.And the serum norepinephrine (NE),5-hydroxytryptamine (5-HT) and dopamine (DA) levels were measured before and 8 weeks after treatment.Results The total effective rate of the observation group was 87.5％,which was significantly higher than 66.1％ in the control group (x2 =7.213,P ＜ 0.05).In the two groups,2,4,8 weeks after treatment,the HAMD scores were significantly lower than those before treatment (t =9.391,19.349,26.349,5.026,12.610,19.518,all P ＜ 0.05),the M ADRS scores were significantly lower than those before treatment (t =8.646,22.190,33.101,4.986,13.185,25.959,all P ＜ 0.05),and the CGI scores were significantly lower than those before treatment(t =17.471,29.482,42.256,13.136,28.358,35.661,all P ＜ 0.05).In the observation group,after treatment for 2,4,8 weeks,the HAMD scores were significantly lower than those in the control group(t =4.093,4.537,5.655,all P ＜ 0.05),and the MADRS scores were significantly lower than those in the control group (t =3.622,9.740,7.490,all P ＜ 0.05),while the CGI scores were significantly lower than those in the control group(t =8.608,11.024,12.598,all P ＜ 0.05).After treatment,the levels of 5-HT,NE and DA were (148.5 ± 4.9) ng/mL,(60.6 ± 4.2) ng/L and (78.0 ± 4.1) ng/L in the observation group,which were significantly higher than before treatment [(79.8 ± 4.3) ng/mL,(30.3 ± 4.0) ng/L and (43.5 ± 4.0) ng/L,t =82.977,41.134,46.837,all P ＜ 0.05].In the control group after treatment,the levels of 5-HT,NE and DA were (125.4 ± 4.1) ng/mL,(40.2 ± 4.0)ng/L and (50.3 ± 4.3)nig/L,which were significantly higher than those before treatment [(79.2 ± 3.9)ng/mL,(30.5 ±4.1)ng/L and (43.2 ±3.6)ng/L,t =64.287,13.334,9.969,all P ＜0.05],but which those in the observation group increased more significantly (t =28.469,27.695,36.286,all P ＜ 0.05).4 weeks and 8 weeks after treatment,the TESS scores in the observation group were (3.0 ± 1.0) points and (4.3 ± 1.2) points,which in the control group were (2.8 ± 1.2) points and (4.1 ± 1.3) points,there were no significant differences in terms of TESS scores (t =1.150,0.846,all P ＞ 0.05).Conclusion EEG biofeedback therapy combined with mirtazapine in the treatment of depression is better,the adverse reactions is not significantly increased,and it also has higher clinical safety compared with mirtazapine alone.

BACKGROUND: Traditional acoustic examination is to make subjective descriptions of abnormal acoustic features, or carry out quantitative analysis of vowels with sensitive consonant utterance only subjected to qualitative analysis.OBJECTIVE: To make quantitative analysis of the acoustic features of sensitive consonants before and after restoration with complete denture. DESIGN: Randomized controlled experiment.SETTING: Department of Prosthodontics; Department of Oral & Maxillofacial Surgery, Ninth People's Hospital of Shanghai Second Medical University.PARTICIPANTS: Totally 30 edentulous patients who received treatment in the Department of Prosthodontics, Ninth People's Hospital of Shanghai Second Medical University, between November 2001 and March 2003-03were enrolled in this study. They were divided into plastic base group and metal base group with 15 patients in each group according to the denture base; the two groups of patients were matched in baseline data such as sex and age. Inclusion criteria: had no history of denture repairing, aged 45-75years, had received certain years of education, could speak Mandarin with out obvious dialect, had no obvious dysaudia (≤ 20dB), and had not received acoustic therapeutic training.METHODS: Plastic base group: the plastic base was 2.0-2.5 mm thick,with smooth anterior palate polished surface. Metal base group: the metal base was 1.0-1.5 mm thick, covering entire palate and forming palatal rugae, which transformed to net base at alveolar ridge side, and cheek base was plastic. The scope of base, the posterior bank of denture, overbite of anterior teeth, coverage degree, occlusal surface and 1/3 vertical range beneath surface were designed conventionally. Utterance of/zi/ and/ji/ by edentulous patients was detected before restoration, at the beginning and after restoration 1, 2, 4, 8 weeks respectively, with the results analyzed with the assistance of computer acoustic analysis system, the linear forecast technology and fast Fourier transformation were used to record the 1st and 3rdformants, the computer acoustic analytic sampling frequency was 10 000 Hz and he step number of linear forecast technology was 12.MAIN OUTCOME MEASURES: The differences in acoustic parameters between the detected utterances/zi/and/ji/.RESULTS: According to the intention-to-treat analysis, 30 patients were enrolled in this experiment and all of them entered the result analysis. ①When utterance/zi/was detected, most of 1st formants were found gradually reduced in plastic base group and metal base group after restoration compared to that before restoration, most obviously at week 8 [(353.67±35.65),(322.60±44.03); (332.27±37.10), (302.20±40.39); P ＜ 0.05]. However,the 3rd formant variance was different between the two groups, presented by gradually ascending in plastic base group and gradually descending in metal base group. ② When the detected utterance was/ci/, changes of the 1st formants in two groups were basically the same as /zi/; moreover the changes of the 3rd formants also displayed different tendency in the two groups.CONCLUSION: Reducing the basal thickness of complete denture and reconstructing palatal rugae will be helpful for the acoustic functional restoration in patients with dentition defects. The computer acoustic analysis system can be used for quantitative analysis of acoustic features of patients before and after restoration with complete denture.