1.Effect of comprehensive intervention on the drug compliance in patients with hepatitis B virus-related hepatocellular carcinoma after receiving TACE
Guomei YOU ; Guoliang SHAO ; Fangying YANG ; Ping ZHU ; Gu ZHAO ; Hui ZENG ; Rui ZHANG ; Lianqin MAO ; Liyao XIA
Journal of Interventional Radiology 2017;26(10):931-934
Objective To investigate the effect of comprehensive intervention led by nursing staffers on the drug compliance in patients with hepatitis B virus-related hepatocellular carcinoma (HCC) after receiving transcatheter arterial chemoembolization (TACE) treatment.Methods By using random sampling method,a total of 96 patients with hepatitis B virus-associated HCC,who had been treated with TACE and had taken nucleotide analogue drug for one month in the interventional department of a certain grade Ⅲ tumor hospital,were enrolled in this study.Under the premise of informed consent,comprehensive intervention,which was led by nursing staffers and was participated by both doctors and nurses,was conducted.Results After comprehensive intervention,the average score of drug compliance was (93.670±6.046) points,while the pre-intervention average score of drug compliance was (82.040±10.024) points,the difference between the two was statistically significant (P<0.05).The ratio of patients who showed good drug compliance changed from pre-intervention 62.4% to post-prevention 97.8%(P<0.05).The post-prevention of patients,whose hepatitis B virus deoxyribonucleic acid (HBVDNA) level was within the normal range,was 45.16%,which was highcr than the pre-intervention ratio of 15.05%,the difference between the two was statistically significant (P<0.05).Conclusion The comprehensive intervention led by nursing staffers can effectively improve the drug compliance in patients with hepatitis B virus-associated HCC after receiving TACE,and can reliably control serum HBVDNA level as well.
2. Role definition in nursing handoff: a focus group study
Xiaoyun WANG ; Dianhui WANG ; Guomei YE ; Deyan CAO ; Xia CUI ; Feifei CHEN ; Xingfeng LIN
Chinese Journal of Practical Nursing 2019;35(33):2617-2620
Objective:
To identify the impeding and promoting factors of role definition in nursing handoff, in order to increase the quality of nursing handoff.
Methods:
Two nursing managers, 22 head nurses and four nurses were recruited by purpose sampling. Data were collected by using focus group study, and analyzed using content analysis.
Results:
According to the framework of role transition theory, the factors could be classified as individual factors (37 items, 23.72%), organizational factors (105 items, 67.31%), effectiveness of role definition (11 items, 7.05%), and problems of role definition (3 items, 1.92%).
Conclusions
Role definition in nursing handoff helping the coming nurse check the performance of the last shift and transfer the nursing responsibility, contributes to the improvement of nursing quality, but there are still many factors affecting the role definition in nursing handoff.
3.Expression and significance of eIF2B1 in hepatocellular carcinoma
Wenyue Qi ; Dachen Zhou ; Zhenhua Zhang ; Guomei Xia ; Wei Chen ; Guizhou Zou
Acta Universitatis Medicinalis Anhui 2023;58(5):799-805
Objective:
To investigate the expression of eukaryotic translation initiation factor 2B1(eIF2B1) in HCC and its correlation with clinical prognosis.
Methods:
Through the follow⁃up of the clinical data of 743 hepatocellular carcinoma patients in the specimen bank ,91 HBV⁃related liver cancer patients with complete follow⁃up information were screened out , and their postoperative tumor tissues were selected. Meanwhile , the adjacent tumor tissues with a
distance of more than 2 cm from the tumor margin were collected to make tissue chips. Western blot and immunohistochemical experiments were performed. Image J was used to analyze the proportion of positive cells stained by tissue chip and the gray value of Western blot results. Clinical data and follow⁃up data of included patients were statistically analyzed by R4. 0. 5 software.
Results:
Immunohistochemical results suggested that eIF2B1 was more strongly expressed in HCC than in para⁃cancerous tissues. Western blot results showed that eIF2B1 was more strongly expressed in HepG2. 2. 15 cells than in HepG2 cells. The expression of eIF2B1 in HCC tissues was correlated with
tumor number (P < 0. 05) . Cox multivariate regression analysis showed that the expression of eIF2B1 was an independent risk factor for the overall clinical prognosis of HBV⁃DNA positive patients (HR = 4. 28 ,P = 0. 018) .
Conclusion
The expression of eIF2B1 is significantly enhanced in HBV⁃associated HCC tissues and is significantly
associated with overall survival in HBV DNA positive patients.