Objective To investigate CT features of XGC in order to improve pre-operative diagnosis of the disease.Methods The CT features of 6 cases with XGC confirmed by histopathology were analyzed retrospectively.Results The gallbladder walls thick-ened in all 6 cases,diffusely thickened in 4 cases and focally thickened in 2 cases.Hypodensity nodules or bands in thickened walls were seen in all 6 cases.The continuous mucosal lines were observed in 4 cases.After contrast administration,the hypodensity band sign was seen in most cases in artery phase.Stones were found in all 6 gallbladders and in 4 common bile ducts,dilatation of biliary tract was seen in 3 cases.There were hepatic involvement in 5 cases,duodenal,hepatic flexure of the colon and antrum of the stom-ach adhesion with gallbladder was seen in 1 case respectively.Conclusion Hypodensity nodules or bands in thickened gallbladder walls and continuous mucosal line are characteristics of XGC,which are helpful in diagnosis and differential diagnosis.

Objective To investigate effect of laparoscope anesthesia inducted by sevoflurane combined with different doses of propofol on vascular endothelial growth factor-C (VEGF-C) and prostaglandin E2(PGE2)in patients with hysteromyoma.Methods 77 cases of patients with uterine fibroids were selected and divided into two groups.40 cases in group A were anesthetized inducted by 2.0 mg/kg propofol combined with sevoflurane, 37cases in group A were anesthesia inducted by 1.0 mg/kg propofol combined with sevoflurane.VEGF-C and PGE2 in serum were compared before and 48h after the operation.Results Compared with preoperation, VEGF-C and PGE2in serum were lower (P<0.05), VAS score was lower (P<0.05);Compared with group B, VEGF-C and PGE2 in serum of the group A were lower (P<0.05), VAS score was higher (P<0.05).Conclusion Different doses of propofol on serum VEGF-C and PGE2 in patients with laparoscopic uterine fibroids have different effects, 1.0 mg/kg has a sedative effect, 2 0 mg/kg with anesthesia induction.

It is a trend that clinical researchers overemphasize on hypothesis testing and the P value. However, P value has some limitations in the presentation of study results. Power is a tool for study design and results explanation, especially for negative results. Confidence interval contains more information for clinical results than P value. P value, power, and 95% confidence interval should be provided in the clinical reports to facilitate the interpretation of the results.

The major developments in SPR technology are reviewed.The principle,parameters and configurations of SPR sensors are also introduced.Then the applications and future prospects of SPR sensor technology in biomedical engineering area are discussed.It is pointed out that the development of this technology tends to further improve the detection sensitivity and resolution,multi-channel detection,the array of micro-devices,etc.

To improve the management level of patients' information of schistosomiasis control stations in Nanchang City,the B/S three-layer architecture and ASP+SQL technology were applied to formulate the WEB-based management system of chronic schistosomiasis patients' information,so as to achieve the information sharing of chronic schistosomiasis among schistosomiasis control stations.

Objective To evaluate clinical effects of the transurethral ureteroscopic lithotripsy(URL) and minimally invasive percutaneous nephrolithotomy(MPCNL) in the management of upper ureteral stones.Methods Clinical data of 258 patients diagnosed as having upper ureteral calculi from January 2001 to December 2004 in this hospital were retrospectively analyzed.The patients were given either URL(225 patients) or MPCNL(33 patients).Results Of the URL,the stone-free rate on one session was 73.8%(166/225) and the failure rate was 26.2%(59/225).The causes for the failure included stone movement to the renal pelvic in 42 patients(18.7%,42/225),unsuccessful manipulation in 14 patients(6.2%,14/225),and conversions to open surgery because of ureteral perforation in 1 patient and ureteral rupture in 2 patients(1.3%,3/225).Of the MPCNL,the stone-free rate on one session was 100%(33/33).Conclusions The application of URL can be interfered with ureteral stricture and twist that are secondary to incarcerated ureteral stones.High stone-free rate,low incidence of complications,and satisfactory reliability can be expected using MPCNL,especially in patients with impacted ureteral calculi accompanied with secondary affection at the same side.

Objective To investigate the clinical and genetic characteristics of hereditary spastic paraplegia(HSP).Methods The clinical material of 113 patients in 39 families with HSP was analyzed retrospectively.Results The ratio of male to female was 1:1.17.The age at HSP onset was from 2 to 58 years old, the mean age was 21.4 years old, and 81.7% of the patients had HSP before 30. 89.4% of the patients had positive family history and they showed mostly autosomal dominant inheritance. The rate of consanguinity was 28.2%. 24 cases had pure while 89 cases had complicated spastic paraplegia. In the HSP group, we could found the weakness of legs in 65.5% patients, spasticity and hyperreflexia of lower limbs in 96.5%, extensor plantar responses in 68.1%, ataxia in 46.9%, muscular atrophy in 32.7% and dementia in 18.6%.Conclusion In the HSP group, the year of onset was mostly before 30. The female HSP cases were more than the male's, and the complicated cases were more often than the pure. Autosomal dominant was the mostly frequent inheritance, and there were more chances of HSP in the consanguineous families.

Objective To discuss the nursing methods of senile uremia patients during induction period of hemodialysis. Methods Improved nursing methods have been adopted since March 2010 in our department.68 senile uremia inpatients from Match 2010 to March 2011 were selected as the observation group,while 59 inpatients from March 2009 to February 2010 were reviewed as the control group.The incidence of complications was compared between the two groups. Results There were 3 cases of arrhythmia,5 cases of hypotension and 2 cases of disequilibrium syndrome in the observation group,while 11 cases of arrhythmia,16 cases of hypotension and 8 cases of disequilibrium syndrome in the control group.3 patients of the control group died of severe arrhythmia.There was statistical difference of complication incidence between the two groups. Conclusions Cardiovascular events are the most severe complications for senile uremia patients during induction period of hemodialysis,which can be reduced by scientific and reasonable nursing.

PurposeTo evaluate 64-slice spiral CT in grading of colorectal adenoma and in the diagnosis of adenocarcinoma.Materials and Methods Sixty-eight cases of pathology confirmed colorectal adenoma were retrospectively reviewed to analyze CT performance including the location, size, shape and their relationship with adjacent structures and degree of enhancement in arterial, venous and delayed phase. The difference of CT attenuation value before and after enhancement (△CT value) in arterial, venous and delay phase of different pathological types and different levels of adenomas were compared.Results Among 68 lesions, 16 were villous adenomas, 42 were tubulovillous adenomas and 10 were tubular adenomas. Villous adenomas and tubulovillous adenomas were characterized by wide base, villous-like with gyral or frond pattern enhancement in arterial phase. There was a layer of low density mucus covering the surface. Tubular adenomas were featured as narrow base, nodular in shape with homogeneous enhancement.△CT values in each phase between villous adenomas and tubular adenomas showed statistically significant difference (arterial phaset=2.56,P<0.05; venous phaset=3.22,P<0.05; delayed phaset=2.48,P<0.05), however no significant difference was shown between villous and tubule villous adenomas or between tubulovillous and tubular adenomas. Adenocarcinomas showed creeping-type growth along the intestinal wall with a cluster of vessels adjacent to the tumor or enlarged lymph nodes.△CT values in each phase between non-dysplasia group and carcinoma group showed statistically significant difference (arterial phaset=2.49,P<0.05; venous phase t=2.69,P<0.05; delayed phaset=2.75,P<0.05), however no significant difference was shown between non-dysplasia group and dysplasia group or between dysplasia group and carcinoma group. Using 50 HU of△CT value in artery phase as standard, the sensitivity and specificity for diagnosis of adenocarcinomas were 76.92% and 70.91%, respectively.Conclusion CT findings of different pathological types of colorectal adenomas and adenocarcinomas are characteristic and useful in preoperative diagnosis and treatment planning.

[Objective] To detect the expression levels of connexin43(Cx43),P-gp and COX-2 in bone marrow of patients with acute leukemia (AL),and investigate their relationship with the pathogenesis,prognosis and resistance of this condition.[Methods]Using SYBR green real-time quantitativereverse transcription polymerase chain reaction (SYBR-RT-PCR),the expression of Cx43,P-gp and COX-2 mRNA were detected in 77 AL patients at different phases,including 36 initially-treated,20 complete-remission (CR)and 20 relapsed.A follow-up was done in those initially lreated.[Results]Expression levels of Cx43,P-gp and COX-2 mRNA from initially-treated were 0.52±0.57,1.42 ±1.06,1.14±0.95;those from relapse AL patients were 0.20±0.40,2.29 ±1.11,1.69±0.81,respectively,those from CR patients were 0.95±0.37,0.93±-0.73,0.79±0.58,respectively,those from normal patients were 1.16 ±0.67,0.86±0.63,0.61±0.57.Expression levels of Cx43 mRNA in initially-treated and relapse AL patients were significantly lower than those in normal patients and CR patients(initially-treated P were 0.001,0.005;relapse patients were P＜0.001),while the comparison between normal patients and CR patients showed no statistical significance(P=0.185).Cx43mRNA expression level was negatively correlated with P-gp and COX-2 mRNA,and a negative correlation was noted of both two expressions in initially-treated and relapse groups (Cx43 mRNA and P-gp mRNA r were -0.471,-0.362,-0.526;Cx43 mRNA and COX-2 mRNA r were -0.479,-0.344,-0.471).A follow-up of four months was conducted in 36 initially-treated patients,eight of them died.The expression Cx43 in those who died was lower than that who survived.The difference was significant(t=2.16,P=0.042).[Conclusion] Cx43mRNA expression levels of initially-treated and relapse AL patients were lower than those in normal patients and CR patients,P-gp and COX-2 mRNA expression levels of initially-treated and relapse AL patients were higher than those in normal patients and CR patients.Cx43 expre-ssion probably is a favorable prognostic factor.Cx43 is participation in the genesis,development and drug resistance of AL.