2.SYNTHESIS OF SARMENTOSIN
Guohua CHU ; Qiting ZHOU ; Donglu BAI
Acta Pharmaceutica Sinica 1999;34(1):0-
AIM: The synthesis of sarmentosin. METHODS: Condensation of butane-1,2,4-triol-1,2-acetonide(3) with α-D-glucopyranosyl bromide tetraacetate in the presence of Ag2O and molecular sieves gave the desired β-glucoside 4,which was transformed into sarmentosin via a reaction sequence of 7 steps. RESULTS: The overall yield is 5.8%. CONCLUSION: The first synthesis of sarmentosin(1),a potent natural GPT lowering agent,was achieved.
3.Application of Multislice Computed Tomography Sagittal Reconstruction for Real Lumbar Spondylolisthesis
Guohua LANG ; Yuzhen WANG ; Fawei XIANG ; Fugang LUAN ; Shili BAI
Chinese Journal of Rehabilitation Theory and Practice 2012;18(9):870-872
Objective To study the application of multislice computed tomography (MSCT) sagittal reconstruction for real lumbar spondylolisthesis. Methods 93 cases with lumbar spondylolisthesis accepted 64-slice MSCT. Their routine CT axial images and sagittal reconstruction images of vertebrae disc were reviewed. Results 93 cases were found with the lumbar spondylolisthesis, 74 cases in class I and 19 cases in class II. 58 cases were found with spondylolisthesis for routine axial CT image. Conclusion MSCT sagittal reconstruction can display spondylolisthesis satisfactorily
4.Effect of obesity and overweight on the hospital stays and total course of common pneumonia in children
Yongli ZHAO ; Zhengjuan LIU ; Xuemei BAI ; Yuchuan WANG ; Guohua LI
Chinese Journal of Applied Clinical Pediatrics 2014;29(7):506-509
Objective To study the effect of obesity and overweight on the hospital stays and total course of common pneumonia in children and the possible reasons.Methods A total of 455 children with common pneumonia aged from 2 to 7 years were enrolled in this study,including 147 obese children,141 overweight children and 167 normal weight children.Then all the children were divided into 2 groups based on age:≥ 2-4 years group and ≥ 4-7 years group.The information of the patients was collected from the medical records management system of our hospital,and including gender,age,weight,height,hospital stays,total course,peripheral blood cell counts (white blood cell,neutrophil,monocyte and lymphocyte),C-reactive protein (CRP),erythrocyte sedimentation rate (ESR),IgG,IgA,CD4 + T,CD8 +T and the history of recurrent pneumonia.Results In ≥ 2-4 years group,the average length of the hospital stays of common pneumonia in obese and overweight children was longer than that in the normal weight children(P =0.037,0.009),and the total course of common pneumonia in obese children was longer than that in the normal weight children (P =0.014).In ≥ 4-7 years group,the average length of the hospital stays and total course of common pneumonia in obese and overweight children were longer than those in the normal weight children (the hospital stay:P =0.002,0.000,the total course:P =0.004,0.001).In ≥2-4 years group,the peripheral blood cell counts(white blood cell,neutrophil,monocyte and lymphocyte),CRP,ESR,IgG,IgA,CD4 + T,CD8 + T,CD4 + T/CD8 + T and the history of recurrent pneumonia were of no significant difference among obese,overweight and normal weight children (all P >0.05).In ≥4-7 years group,the peripheral blood cell counts(white blood cell,neutrophil,monocyte and lymphocyte),and ESR were of no significant difference among obese,overweight and normal weight children (all P > 0.05),but the levels of IgG,CD4 + T and CD4 + T/CD8 + T in obese and overweight children were lower than those in the normal weight children,and the obese children were more notable in this aspect (P < 0.05).And obese and overweight children were more likely to suffer from recurrent pneumonia.Conclusions Obese and overweight children with common pneumonia aged from 2 to 7 years may need longer hospital stay and total course than normal weight children.Impaired immunity may be the main reason for the ≥4-7 years group,but in the ≥2-4 years old group,it may be attribute to some non-immune factors.
5.Research progress of signal processing method for bioradar
Jun BAI ; Xiao ZHANG ; Pengfei ZHANG ; Guohua LU ; Jianqi WANG
International Journal of Biomedical Engineering 2013;(1):44-47
Bioradar is based on the integration of theory of radar and bio-medical engineering,which can detect the life-parameters in farther distance.It is new concept radar presented by foreign experts.The technology can be widely used in detection of lifeform signal and non-contact clinical monitoring.Biomedical signal processing method is the premise that the technology can be realized.The signals can be interfered by the environmental factors,breath motion and so on,especially the influences of breath motion which can not be solved by average methods.A large number of signal processing methods are used in various aspects of the technology.This review introduces the progress of bioradar technology and the application of the current signal processing methods in the field.
6.Preparation and Experimental Study on Dielectrophoresis- Based Microfluidic Chip for Cell Patterning
Yang ZHANG ; Xiaofei ZHANG ; Guohua BAI ; Ming FANG ; Qiulin TAN ; Jijun XIONG ; Dong SUN
Chinese Journal of Analytical Chemistry 2014;(11):1568-1573
Adielectrophoresis-basedmicrofluidicchipappliedtocellspatterningisdesignedandfabricated, and it demonstrates non-contact and batch manipulation of cells. The microfluidic chip employs a PDMS microchannel and two ITO electrodes, which are designed as astep shape. The distribution of electric field caused by the microelectrodes is simulated by finite element simulation software, COMSOL. The position of the maximum intensity of electric field is also determined. The ITO microelectrodes and the PDMS microchannel are fabricated using MEMS fabrication process. After oxygen plasma surface treatment, the PDMS microchannel and glass substrate with the ITO microelectrodes are aligned and bonded to form experimental microfluidic chip. Through DEP experiment with the varying frequencies, DEP response of yeast cells is examined, and the electric field frequency of the both positive and negative DEP responses are confirmed. The results showed that yeast cells in solution conductivity of 60 μS/cm had negative DEP movement at the frequency of 1 kHz to 10 kHz, positive DEP movement at the 500 kHz to 10 MHz, and no DEP movement at the 50 kHz. Under the condition of the sinusoidal potential of 8Vp-p and the electric field frequency of 5 MHz, the yeast cells were aligned into chains along the step edge of microelectrodes.
7.Interventional treatment for hemorrhage following biliary and pancreatic surgery
Guohua LI ; Weihong YANG ; Yingmei SONG ; Yongming BAI ; Ruixing DOU ; Nonesu HE
Journal of Interventional Radiology 1992;0(01):-
Objective To study the tactics, methods and relevant factors of interventional treatment for hemorrhage following biliary and pancreatic surgery.Methods Fourteen patients with hemorrhage following biliary and pancreatic surgery were treated by embolization using gelfoam pledgets, PVA granules, metal coils or otherwise by local infusion of vasopressin. Results There were 16 foci in 14 patients with 16 times of interventional treatment, including 3 times using metal coils, 6 times of PVA, 2 gelfoam pledgets, 1 with PVA plus gelfoam pledgets, and 4 of vasopressin. There was 1/16 time failure of using vasopressin due to anastomotic rupture. The successful rate reached 93.8%. Conclusions Interventional treatment is a safe and effective method for hemorrhage following biliary and pancreatic surgery. The key of success is the right selection of embolization or vasopressin infusion for target artery.
8.Research progress of the measurement technology for respiration signal
Pengfei ZHANG ; Hua ZHANG ; Jun BAI ; Yanfeng LI ; Xijing JING ; Guohua LU ; Jianqi WANG
International Journal of Biomedical Engineering 2012;(6):365-368,380
The measurement methods of respiration can be mainly divided into contact and non-contact.Contact detection methods include volumetric flowmeter,velocity flowmeter,temperature detection,displacement detection,impedance detection,wearable technology and sleep mattress,etc.Although these methods are noninvasive and mature,they all require electrodes or sensors to touch the body of human subjects,which limit the users’ freedom and are not suitable for severely bumed patients and newborns.In non-contact monitoring,the respiration is measured by using the media such as electromagnetic waves,optical media,etc,and without any electrodes or sensors to touch the body whiles the human subject keeping natural status.Non-contact detection method using infrared and biological radar has been a research focus both at home and abroad,which can be used for clinical,community and family care.
9.Association between serum amyloid A and intima-media thickness of common carotid artery in patients with type 2 diabetes
Yu YANG ; Jianling DU ; Xiujuan ZHANG ; Ran BAI ; Ying BA ; Qian XING ; Lipeng SUN ; Guohua SUN ; Changchen LI
Chinese Journal of Endocrinology and Metabolism 2008;24(2):188-189
A total of 169 patients with short-duration type 2 diabetic mellitus (DM) were divided into atherosclerosis (AS) group and non-AS group according to the intima-media thickness (IMT) of three conducting arteries.The level of serum amyloid A (SAA) was assayed by ELISA.The results showed that SAA level of type 2 DM patients increased significantly, patients in AS group showed higher SAA level than that in non-AS group, and SAA level was positively correlated with age, body mass index, waist hip ratio and IMT of common carotid artery.Age, C-reactive protein and SAA level are the major risk factors for IMT of common carotid artery.
10.Relationship between prevalence of Kashin-Beck disease and ecological environment in Gansu Province
Xiaoyan CHEN ; Jian HE ; Wenlong GAO ; Jianyun SHAO ; Guohua CHEN ; Yongjian LIAO ; Ping LI ; Suqin YU ; Shuying BAI
Chinese Journal of Endemiology 2016;35(12):908-912
Objective To explore the relationship between prevalence of Kashin-Beck disease (KBD) and ecological environment, and to broaden the perspective of KBD etiology. Methods In 37 counties of KBD areas in Gansu Province, information about the ecological environment and implementation situation of control measures (altitude, temperature, rainfall, evapo ration, frost free period, annual sunshine hours, population density, per capita income, the proportion of staple food, returning farmland to forest, to forestry and replant crops) and X-ray detection rate of KBD of 7-12-year-old children in 2012 - 2014 was collected. Using four quantile regression method, the regression model was introduced to analyze the 11 ecological factors which related to the pathogenesis of KBD. The effect of three points on X-ray detection rate of KBD was estimated. Results The X-ray detection rate of KBD was independent of altitude, temperature, evaporation, population density, per capita income and cash crops, and was dependent of rainfall, frost free period, annual sunshine hours, the staple food purchase ratio, and returning farmland to forest and grassland. No matter where in any place numbered, the higher rainfall (measure value:0.003 3 to 0.006 4), the longer frost free period (measure value: 0.029 2 to 0.043 8), the longer annual sunshine hours (measure value:0.001 6 to 0.001 8), and the higher staple food purchase ratio (measure value:0.019 7 to 0.027 6), the higher risk of X-ray detection rate of KBD; the higher returning farmland to forest and to grassland, the lower risk of X-ray detection rate of KBD (measure value: - 0.037 2 to - 0.013 3). Conclusion The X-ray detection rate of KBD is closely related to local ecological environment.