1.Nutritional risk screening in hospitalized patients with respiratory disorders
Pingji ZHANG ; Jing BIAN ; Yeping ZHOU ; Guoguang XIA
Chinese Journal of Clinical Nutrition 2009;17(2):79-81
Objective To explore the nutrition risk,undemutrition rates,and nutrirlon support in the hos-pitalized patients with respiratory disorders.Methods Totally 100 hospitalized patients in department of respirato-ry medicine of our hospital from October to December 2008 were enrolled in this study.The nutrition risks were screened on the next day after admission and then two weeks later using Nutrition Risk Screening(NRS2002).Body mass index(BMI)lower than 18.5 ks/m2,serum albumin(sALB)lower than 35 g/L,or pre-ALB was lower than 20 g/L Wag regarded as undemutrition.Results Among all these 100 patients evaluated by NRS2002,59 patients were judged at the risk of malnutrition and 54 patients developed undemutrition two weekB later The nutrition risk and undernutuition rate among non-ambulatory patients were 87.7%and 82.9%,which were signifi-cantly higher than in ambulatory patients(32.2%and 30.5%)(P<0.001).The nutrition risk and undernutu-ition rate were also significantly higher in patients who stayed in the hospital for more than 2 weeks than those for less than 2 weeks(75.0% vs 9.4%and 66.2% vs 21.9%,respectively)(P<0.001).Twenty-two patients received nutritional support.The ratio of parenteral nutrition and enteral nutrition wag 1.2:1.Conclusions NRS2002 can be used in the nutrition assessment in hospitalized patients with respiratory disorders.Non-ambulato-ry and a hospital stay of more than 2 weeks increase the nutritional risk and undemutrition rate.Only a small per-centage of patients receive nutritional support.
2.Early appearance of SARS on chest CT scan
Xiaoguang CHENG ; Suchen FENG ; Guoguang XIA ; Tao ZHAO ; Xiang GU ; Hui QU
Chinese Journal of Radiology 2001;0(09):-
Objective To evaluate the early appearance of SARS on chest CT scan and its role in the early diagnosis Methods Forty cases of SARS in keeping with the criteria of the Ministry of Health had chest CT scans within 7 days of onset of symptoms, and CR chest X-ray films were available as well These chest X-rays and CT images were retrospectively reviewed to determine if there were any abnormalities on the images The lesions on the chest CT images were then further analyzed in terms of the number, location, size, and density Results Positive abnormalities on chest CT scans were revealed in all 40 SARS cases Positive findings on CR chest films were showed in only 25 cases, equivocal in 6, and normal in 9 cases The main abnormalities seen on CT and X-rays were pulmonary infiltrations varied markedly in severity 70% cases had 1 or 2 lesions on chest CT scan, 30% cases had 3 or more lesions The lesions seen on chest CT scan tended to be ground-glass opacification, sometimes with consolidation which was very faint and inhomogeneous, easily missed on chest X-rays Typically the lesions were located in the periphery of the lung, or both central and peripheral lung, but very rare in a pure central location They were commonly in the shape of patch or ball Conclusions Chest CT scan is much more sensitive in detecting the lesions of the lung in SARS The early appearance of SARS on chest CT scan is characteristic but non-specific, indicating that chest CT scan plays a very important role in the early diagnosis and differential diagnosis of SARS
3.Influence of hormones on osseointegration in dental implant
LUO Cuifen ; PENG Guoguang ; FENG Yuanhua ; XIA Wei ; SHEN Lin ; HE Shanzhi
Journal of Prevention and Treatment for Stomatological Diseases 2017;25(7):473-476
Osseointegration plays an important role in the functions and aesthetics of dental implant. This paper focus on the hormones closely related to the bone metabolism, including glucocorticoid, parathyroid hormone, calcitonin, melatonin, and oestrogen, and reviews the influence of hormones on the osseointegration.
4.Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer.
Haiyang ZHANG ; Jingjing DUAN ; Yanjun QU ; Ting DENG ; Rui LIU ; Le ZHANG ; Ming BAI ; Jialu LI ; Tao NING ; Shaohua GE ; Xia WANG ; Zhenzhen WANG ; Qian FAN ; Hongli LI ; Guoguang YING ; Dingzhi HUANG ; Yi BA
Protein & Cell 2016;7(2):141-151
Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3'UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.
Animals
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Apoptosis
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genetics
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Apoptosis Regulatory Proteins
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deficiency
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genetics
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Base Sequence
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Bcl-2-Like Protein 11
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Cell Line, Tumor
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Cell Movement
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genetics
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Cell Proliferation
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genetics
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Down-Regulation
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genetics
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Gene Silencing
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Male
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Membrane Proteins
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deficiency
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genetics
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Mice
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MicroRNAs
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genetics
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Proto-Oncogene Proteins
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deficiency
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genetics
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Rats
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Stomach Neoplasms
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genetics
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pathology