1.Pharmacokinetics and relative bioavailablity of domestic penicillin V dispersion tablet
Furong QIU ; Guoguang MAO ; Hua SUN ; Min DAI ; Zhaohong ZENG ; Bo CHEN ; Qiu ZHONG ; Yueming MA ;
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(02):-
Aim To study pharmacokinetics and bioavailablity of domestic penicillin V dispersion tablet in healthy volunteers. Methods According to the crossover design, each volunteer in two groups was orally given a single dose ( 0.75 g ) of domestic penicillin V dispersion tablet or imported penicillinV tablet alternately and the plasma concentrations were determined by RP HPLC. The pharmacokinetic parameters were obtained by using ATPK program and calculated on the basis of open single compartment model. Results After a single oral dose( 0.75 g ), the t 1/2(ke) was ( 0.75 ? 0.10 ) h and ( 0.70 ? 0.14 ) h ,the c max was( 8.44 ? 2.40 ) mg?L -1 and ( 8.75 ? 3.04 ) mg?L -1 at ( 0.56 ? 0.11 ) h and ( 0.63 ? 0.17 ) h and AUC 0~4 was( 8.44 ? 2.40 ) mg?h?L -1 and ( 8.75 ? 3.04 ) mg?h?L -1 for two formulations, respectively. Relative bioavailability of domestic penicillin V dispersion tablet was ( 90.50 ? 8.84 )%. Conclusion The result shows that the two formulations are bioequivalent.
2.Breeding of APPSWE transgenic mice and gene identification of filial generation
Guoying LI ; Ge ZHANG ; Jinjia HU ; Huaqiao WANG ; Guoguang QIU ; Zhibi YAO
Chinese Journal of Pathophysiology 1986;0(01):-
0 05), but there were significant differen t between the positive rates with APPSWE gene (P