1.The effect of glucocorticoids in patients with acute exacerbation of severe COPD and its impacts on the serum levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase-1
Peifang ZHANG ; Zhiyang LUO ; Lixian ZHENG ; Zhanqiang MEI ; Guocui ZHEN
Clinical Medicine of China 2010;26(1):38-40
Objective To explore the role of matrix metalloproteinase 9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)in patients with acute exacerbation of severe chronic obstructive pulmonary diseases (AECOPD)treated with glucocorticoids.Methods The serum levels of MMP-9 and TIMP-1 were measured by ELISA in 41 patients with AECOPD before and after treatment with glucocorticoids and in 40 patients with regular methods(control group).Results ①After treatment with glucocorticoids,the serum levels of MMP-9(189.25±52.38)μg/L、TIMP-1(198.38±43.45)μg/L,ratio of MMP-9/TIMP-1(0.92±0.37)were decreased significantly than before((246.10±68.64)μg/L,(217.63±62.34)μg/L,(1.09±0.23))(P<0.01,P<0.05,P<0.05);but there were no differences(P>0.05)in regular methods(control group);② After treatment with glucoeorticoids, FEV_1、FEV_1%((0.83±0.35)L,(46±17)%)were impmved than before((0.72±0.48)L,(34±15)%)(P<0.05).Conclusions After treatment with glucocorticoids,the serum levels of MMP-9、TIMP-1、ratio of MMP-9/TIMP-1 from patients with COPD were decreased significandy,and FEV_1、FEV_1%were improved significant;Glucocorticoids can alleviate severs AECOPD to some degrees,which might be related to improving the imbalance of MMP-9/TIMP-1.
2.The application of temperature-controlled bipolar radiofrequency ablation in treatment of snoring and obstructive sleep apnea hyponea syndrome
Yong ZENG ; Runhan LI ; Yuejian WANG ; Weixiong CHEN ; Jianxiang XIAO ; Guocui ZHEN
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(03):-
OBJECTIVE To explore the clinical effect of tonsil temperature-controlled bipolar radiofrequency ablation technology in the treatment of snoring and mild-moderate-obstructive sleep apnea hyponea syndrome(OSAHS). METHODS Forty-six patients were selected,of which 17 were snoring and 29 were mild-moderate-obstructive sleep apnea-hyponea syndrome cases. Tonsil temperature-controlled bipolar radiofrequency with varying probes was used for all patients. RESULTS A follow-up of 6～18 months was carried out. 9 of 17 snoring cases resulted in recovery. The procedure was effective in 6 cases and not effective in 2 cases. 15 of 29 OSAHS cases resulted in recovery. The procedure was effective in 10 cases and not effective in 4 cases. Overall successful rate was 86.9 %(40/46). The size of tonsils, apnea hyponea index(AHI),snoring scale and Epworth sleepiness score(ESS)were significantly decrease dafter operation(P
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