1.LONG-TERM OUTCOME OF 284 CASES OF GRAVES' DISEASE AFTER CESSATION OF ANTITHYROID DRUGS
Chinese Journal of Endocrinology and Metabolism 1985;0(01):-
Two-hundred-eighty-four patients with Graves' disease were followed up retrospectively and prospectively for from 6 months to 25 years after cessation of antithyroid drugs. The remission rate was found to be 65.6% (149/227) at 2 years, 53.5% (68/127) at 5 years and 38.8% (19/49) at 10 years and over. In order to study the remission rate with respect to the duration of treatment, the patients were divided into 3 groups: short-term (6.7?1.5 mos), mid-term(14.3 ?2.3mos)and long-term(26.1 ? 8.3mos). The remission rate was not statistically different among the 3 groups. T3 suppression and TRH stimulation tests were performed on 62 cases at discontinuation of the drugs and repeated on 20 cases 1 year later. Response to T3 suppression varied significantly among different groups immediately following cessation of therapy, but no similar difference Was demonstrated 1 year later. The present study indicates that serum levels of T3 and T4 and size of the goiter before treatment and the results of T3 suppression test as well may be of some value in predicting the outcome of anti-thyroid drug therapy. Since most of the patients with long-term remission were those who had received short-term therapy, it is suggested that about 6-month drug administration would seem to be just as effective as therapy of I onger durations.
2.CHANGES OF SERUM CALCIUM AND PARATHYROID HORMONE IN HYPERTHYROID PATIENTS
Chinese Journal of Endocrinology and Metabolism 1985;0(01):-
Serum calcium inorganic phosphate and parathyroid hormone (PTH) were measured in 24 patients with hyperthyroi-dism before and after antithyroid treatment. The levels of serum calcium dropped from 2.47 + 0.05 mmol / L (M + SE) to 2.30 +0.04 mmol/L following treatment (t = 2.83, p0.05). The levels of serum PTH rose from 51.88+ 7.15 pg / ml before the treatment to 75.17 +7.41 pg / ml after the treatment (t = 4.44, p
3.ALTERATION OF PITUITARY GROWTH HORMONE RESERVE IN HYPOTHYROIDISM
Chinese Journal of Endocrinology and Metabolism 1986;0(04):-
In order to investigate influence of hypothyroidism on pituitary growth hormone (GH) reserve, a study was conducted on 14 patients with primary hypothyroidism (females 12, males 2; age range 15-58 yrs.) by measuring the response of GH to insulin-induced hypoglycaemia. Twenty healthy persons were used as normal controls. The serum peak GH values after hypoglycaemia were 18.84+7.17 ug/L in the patient group and 35.31 +3.98 ug/L in the controls. The difference was statistically significant (t = 2.157, p
4.The expression of CD4~+ CD25~+ T cells in the patients with systemic lupus erythematosus
Li LUO ; Guochun WANG ; Li WEI
Chinese Journal of Immunology 1985;0(06):-
Objective:To investigate the expressions of CD4+ CD25+ T cells and IL-10 in the peripheral blood of patients with systemic lupus erythematosus(SLE) and their clinical significance.Methods:Thirty SLE patients(seventeen active and thirteen remissive) and twenty normal controls were enrolled in the study. Flow-cytometric assay was employed for detection of CD4+ CD25+ T cells,and double antibody sandwich ELISA was applied to detect IL-10 in sera from SLE patients and normal controls.Results:The levels of CD4+ T cells in active and remissive SLE were significant lower than normal controls; the positive rate of CD4+ CD25+ T cells in both active and remissive SLE was higher than that in normal controls; the levels of IL-10 in active stage of SLE were significant higher than in remissive stage of SLE or in normal controls. No correlation was found among the levels of CD4+ CD25+ T cells or IL-10 in SLE with SLEDAI scores, anti-DNA and C3 level.Conclusion:CD4+ CD25+ T cells in the peripheral blood of patients with SLE are the marker for activation of T-cells, and aberrant IL-10 production was related with onset of SLE.
5.The effect of short-term intensive insulin therapy on insulin secretion of different phases in newly diagnosed type 2 diabetics
Guochun LUO ; Zhen LIANG ; Qinghong HU
Chinese Journal of Diabetes 1995;0(04):-
Objective Hyperglycemic clamp technique (HGCT) was performed to evaluate the effect of short-term intensive insulin therapy on the first and second-phase (1PH and 2PH) insulin secretion and maximum insulin secretion (MIS) in newly diagnosed type 2 diabetics. Methods Twelve volunteers with normal glucose tolerance (NC group) and six newly diagnosed type 2 diabetics (DM group) were included and HGCT was performed to assess the function of pancreatic islet beta cell. Then HGCT was repeated in the 6 patients following two week intensive insulin therapy. Results The levels of secreted insulin in 1PH, 2PH and MIS were 257?36 mU/L, 63?5 mU/L and 80?5 mU/L in NC group respectively, and 95?19 mU/L, 34?9 mU/L and 39?12 mU/L in DM group respectively. 1PH insulin secretion was significantly improved in the diabetics following 2 week treatment compared with that before the treatment (135?27 mU/L vs 95?19 mU/L, P=0.01). The insulin secretions in 2PH and MIS were slightly increased (40?9 mU/L vs 34?9 mU/L, P=0.09, 46?11 mU/L vs 39?12 mU/L,P=0.08, respectively). Conclusions Short-term intensive insulin therapy can improve the insulin secretions significantly in 1PH and slightly in 2PH and MIS in newly diagnosed type 2 diabetics.
6.EFFECT OF THYROID FUNCTION ON THE SECRETION OF ACTH AND CORTISOL
Jiangyuan LI ; Guochun LUO ; Sizhen LU
Medical Journal of Chinese People's Liberation Army 1983;0(05):-
Patients with thyrotoxicosis had a normal circadian rhythm of ACTH and F,but the level of serum F was lower than controls due to excessive degradation.The responsiveness of ACTH to dexamet-hasone suppression or insulin hypoglycemic stimulation was normal.Whereas the circadian secretion of ACTH and F was also normal in patients with primary hypothyroidism,and the concentration of F was inreased with normal ACTH level.There were stunted responses of ACTH to suppressing and stimulating tests,which were thought to be due to the fact that the corticotropes were impaired by hypertrophy or hyperplasia of thyrotropes in primary hypothyroidism.
7.THE PRELIMINARY STUDY ON THE CHANGES IN THE EXPRESSION OF G PROTEINS ? SUBUNIT mRNA IN THYROID TUMOR
Zhaohui LU ; Guochun LUO ; Changy PAN
Medical Journal of Chinese People's Liberation Army 2001;0(11):-
To investigate the changes in the expression of G proteins ? subunit mRNA in non functioning thyroid adenoma (NFTA) and thyroid papillary cancer (TPC). Eleven thyroid specimens were obtained during surgery, 6 of which from patients with NFTA and 5 from patients with TPC. The expression levels of stimulating and inhibiting G protein ? subunit mRNAs were determined by reverse transcription polymerase chain reaction (RT PCR). The expression levels of Gsa mRNA in TPCs were significantly higher than those in normal thyroids and NFTAs( P
8.The effects of glycemic control on ophthalmic refraction in diabetic patients
Haiyan LI ; Guochun LUO ; Jiang GUO ; Zhen LIANG
Chinese Journal of Internal Medicine 2010;49(10):855-858
Objective To evaluate effects of glycemic control on refraction in diabetic patients.Methods Twenty newly diagnosed diabetic patients were included in this study. The random blood glucose,glycosylated hemoglobin A1c( HbA1c) levels, fasting C-peptide and postprandial 2 h C-peptide levels were measured before treatment. The patients with random blood glucose ≥ 12. 0 mmol/L and HbA1c ≥ 10. 0%were selected. Refraction, intraocular pressure, radius of the anterior corneal curvature, depth of the anterior chamber, lens thickness, vitreous length, and axial length were measured on admission and at the end of week 1,2, 3 and 4 during glycaemic control. Results A transient hyperopic change occurred in all the patients receiving glycemic control with a mean maximum hyperopic changes of 1.6 D ( 0. 50 D ~ 3.20 D). There was a positive correlation between the magnitude of the maximum hyperopic changes and the HbA1 c levels on admission ( r = 0.84, P < 0.05 ). There was a positive correlation between the magnitude of the maximum hyperopic changes and the daily rate of blood glucose reduction over the first 7 days of the treatment ( r = 0.53, P < 0.05 ). There was no significant correlation between the magnitude of the maximum hyperopic changes and the levels of random blood glucose on admission. No significant correlation was observed between the maximum hyperopic changes and fasting C-peptide or postprandial 2 h C-peptide.There were no significant correlations between the magnitude of the maximum hyperopic changes and age,blood press, body mass index, triglyceride, total cholesterol, low-density lipoprotein or high-density lipoprotein. No significant changes were observed in the intraocular pressure, radius of the anterior corneal curvature, depth of the anterior chamber, lens thickness, vitreous length and axial length during glycemic control. Conclusions Transient hyperopic changes occur after glycemic control in diabetic patients with severe hyperglycaemia. The degrees of transient hyperopia are highly dependent on HbA1c levels before treatment and the rate of reduction of glucose level over the first 7 days of treatment. This is probably due to the decrease of refractive power by lens hydration, not morphological change of lens.
9.Therapeutic efficiency of seretide plus montelukast on patients with asthma and effect on the serum IL-6 and TNF-α
Liming LUO ; Wenqing CHEN ; Biao HUANG ; Zhihe CHEN ; Guochun HUANG
Chinese Journal of Primary Medicine and Pharmacy 2009;16(z1):4-5
Objective To investigate the effect of seretide plus montelukast on clinical symptoms、pulmonary functions and the serum IL-6 and TNF-α of patients with asthma.Methods 73 cases patients with asthma were randomly divided into seretide group and seretide plus montelukast group and were treated respectively for two weeks.The clinical symptoms,lung functions and serum IL-6,TNF-α contents of patients were measured respectively before treatment and after two weeks treatment.Results After two weeks treatment,the clinical symptom scores、FEV1.0、FVC and PEFR of two groups had significantly changed than that before treatment(P<0.05);Each index was further compared after treatment,and it was found that two groups had significant differernces statistically (P<0.05),these showed that combination of seretide and montelukast could significantly enhance the therapeutic effect.After treatment,the TNF-α and IL-6 contents in the peripheral blood of seretide group and seretide plus montelukast group had both significantly reducted (P<0.05 or P<0.01);The TNF-α and IL-6 contents of seretide plus montelukast group had reduced more significantly than that of the seretide group(P<0.05).Conclusion The seretide plus montelukast group could improve the clinical symptoms and pulmonary function of patients with asthma,and the action mechanism might be related to lower the serum IL-6 and TNF-α contents.
10.Evaluation of insulin resistance in type 1 diabetes with euglycemic-hyperinsulinemic clamp
Guochun LUO ; Zhen LIANG ; Qinghong HU ; Dewen YAN ; Lingbo LU ; Wenhui GU ; Zelong CHEN ; Haiyan LI ; Mingming LIU
Chinese Journal of Internal Medicine 2009;48(1):10-12
Objective To investigate insulin resistance in type 1 diabetes(T1DM)with euglycemic-hyperinsulinemic clamp.Methods Eight cases of newly diagnosed T1DM and 8 cases of newly diagnosed type 2 diabetes(T2DM)were selected.Their insulin sensitivity index(ISI)was evaluated with euglycemic-hyperinsulinemic clamp after 2 week insulin intensive treatment and compared with that of 10 heMthy volunteers(normal control group,NC group).Results Age,BMI,fasting insulin(Fins),fasting C-peptide in the TI DM group were significantly lower than those in the NC group.while waist-to-hip ratio (WHR),systolic blood pressure(SBP),diastolic blood pressure(DBP),TC,TG,LDL-C,HDL-C were not significantly different between the T1DM and NC groups.Age,BMI,WHR,Fins,fasting C-peptide,SBP,TC,TG in the T1DM group were significantly lower than those in the T2DM group.The ISI of the NC,TlDM and T2DM groups were 12.83±1.09,9.95±0.50,3.80±0.20,respectively.There was significant difference among the three groups(P<0.05).Conclusion The ISI in T1DM Was significantly lower than that in NC group,but higher than that in T2DM.