Objective To investigate the change ofpermeability surfaces (PS) of CTperfusion(CT-p) before chemotherapy and early period treatment with chemotherapy (the first cycle of chemotherapy) in advanced non-small cell lung cancer and explore the correlation with the efficacy of chemotherapy.Methods Eighty patients with advanced non-small cell lung cancer which confirmed by pathology were taken standardized treatment by first-line drug.All patients performed with the CT-p technique before chemotherapy and one cycle after chemotherapy.The efficacy was evaluated by RECIST after 4 cycles of chemotherapy,the patients were divided into complete remission (CR) + partial response (PR),stable (SD),development (PD) according to the results and the change of PS was compared among these groups before chemotherapy and after 1 cycle of chemotherapy.Results Seventy-four patients' values of PS were useful.The remission rate and the stability rate was 32.4％ (24/74) and 78.4％ (58/74) respectively after 4 cycles of chemotherapy.PS after 1 cycle of chemotherapy in CR +PR (24 cases) and SD (34 cases) was lower than that before chemotherapy (12.38 ± 1.86 vs.18.13 ± 2.45,13.24 ± 1.97 vs.17.93 ± 2.38),and there was significant difference (P ＜0.05).There was no obvious change in PS before chemotherapy and after 1 cycle of chemotherapy in PD (16 cases),and there was no significant difference(P＞ 0.05).Conclusions The value of PS which reflects the change of perfusion in tumor vessel at early chemotherapy and the prognosis of the non-small cell lung cancer.Use the change of PS to predict the prognosis of patients with chemotherapy.It could be the norm of calculating the curative effect of chemotherapy in non-small cell lung cancer.

Hepatocellular carcinoma (HCC) complicated by arterioportal shunt (APS) is commonly seen in clinical practice,with an incidence rate of 28.8％-63.2％.It is manifested as abdominal pain,diarrhea,and ascites and can also lead to serious complications of portal hypertension including gastrointestinal bleeding.Although there are various therapeutic methods,they tend to have poor clinical effects.APS is one of the most important causes of death in patients with HCC.This article introduces the etiology,typing,clinical manifestation,and therapies of HCC complicated by APS and points out that although there are various therapeutic methods for HCC complicated by APS,interventional treatment remains the most important method.The exploration of interventional treatment helps to improve patients' prognosis.

Mutual promotion, mutual assistance and mutual inhibition are commonly for the compatibility of Chinese herbs, but they are also existed among the acupoints. In the paper, the relevant literature on acupoint, compatibility was collected and the mutual promotion, mutual assistance and mutual inhibition relationships of acupoints were described. The laws of the above mentioned combinations, the theoretic evidences and modern researches were summarized briefly. The mutual promotion and mutual assistance refer to the coordination of acupoints, presenting the relationship of the primary and the secondary about the mutual assistance. Hereby, the acupoints could be divided into the simple assistant acupoints and the acupoints from the affected meridians. The mutual inhibition is used to describe the antagonism effect in acupoint combination. There are more researches on the mutual promotion of acupoint combination but less ones on the mutual inhibition and its mechanism is just hypothetic. It is very important to have the deep study on those compatibility relationships for the improvement of acupuncture efficacy and to elaborate the effect mechanism.
Acupuncture Points ; Acupuncture Therapy ; history ; China ; History, Ancient ; Humans ; Medicine in Literature ; Meridians

Objective To investigate the influence of insulin pump on type 2 diabetes mellitus.Methods 51 patients were randomized into two groups: 31 cases controlled with insulin pump,20 treated with oral antidiabetic drugs.Serum level of C-peptide concentration was observed.Results There was a markedly increase in C-peptide level in both insulin treating group(P<0.001) and oral drug group(P<0.01).Half an year later,the insulin group was improved in β-cell function better than oral drug group.Conclusions Several days controlling of severe hyperglycemia with insulin pump could not eliminate the β-cell inhibition of glucose toxicity.Newly diagnosed severe type 2 diabetes(FPG≥14 mmol/L) could be treated with insulin for several months.

Objective To analyze the onset, clinical manifestation, causation, complications of pediatric uveitis. MethodsOne hundred and two patients with uveitis under 16 year-old were retrospectively studied. They visited the clinic in Peking University First Hospital from November 1979 to December 2008. Their age ranged from 2.5 to 16 years old, with a mcan of 11.9 years. Routine exam was carried out, including visual acuity, slit lamp, fundus, and laboratory workup. The diagnosis and classification were made by the anatomic location according to the standard of The International Uveitis Working Group. The data of disease history, age of onset, manifestation, recurrence, causation, systemic diseases, complications, and lab examination were analyzed. Results A total of 102 patients (170 eyes)with pediatric uveitis were included in this study, 68 patients (66.6%) were bilateral cases. Anterior uveitis represented in 38 patients (37.3% ), intermediate uveitis in 19 (18.6%), posterior uveitis in 10 (9.8%),and panuveitis in 35 (34.3%). The disease duration was from five days to 2.4 years, with a mean of 3.6 months. The follow-up time was two weeks to more than ten years. The first three causes of pediatric uveitis were juvenile idiopathic arthritis, Vogt-Koyanagi Harada disease, and Behcet's disease. 36 patients were found with complications, and among them 19 had complicated cataract, seven had secondary glaucoma, five had corneal band dystrophy, 12 had iris synechia (both anterior and posterior), one had retinal detachment, two had eye atrophy, and one patient with juvenile idiopathic arthritis had bilateral femoral head necrosis because of the use of steroid and hip joint was replaced. There were ten children suffering more than two complications. Conclusions Pediatric uveitis is a possible blindness disease with variety of etiology and manifestations, and tends to cause complications. Early and special attention must be taken to avoid serious consequences.

Different from the general local hospital,the affiliated hospital of medical school plays double social roles that it not only serves as a teaching hospital but also a medical uniL Every medical staff in it shoulders the responsibility of teaching,researching and medical treatmenL According to the relative independence of affiliated hospital in comprehensive university,the particularity of professional and technical post,the multiplicity of post task,as well as problems existed in the current appraisal and appointment of professional and technical posts such as lacking objectivity and maneuverability in clinical skills examination and evaluation.the paper tries to put forward a new mode of clinical skills examination and evaluation system in accordance with the characteristics of affiliated hospital.

Objective To investigate the activation mechanism of matrix metalloproteinase-13 zymogen (pro-MMP-13) induced by nitric oxide (NO). Methods Human chondrosarcoma cells (SW1353) were grouped and treated with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP), SNAP + NO scavenger oxyhemoglobin (OxyHb), and SNAP + tissue inhibitor of metalloproteinase material -2 (TIMP-2) respectively. After stimulation, matrix metalloproteinase -13 ( a-MMP-13 ) expression level was detected. Besides, the expression levels of MT1- MMP were detected after SW1353 cells stimulated with SNAP and SNAP + OxyHb, respectively. At last, the activities of the recombinant MMP-13 (r-MMP-13) were detected after r-MMP-13 stimulated with SNAP, recombinant MT1-MMP (r-MT1-MMP) and r-MT1-MMP + TIMP-2,respectively. Results SNAP increased human chondrocytes a-MMP-13 expression, OxyHb and TIMP-2 inhibited a- MMP- 13 expression. SNAP also increased the expression of MT1- MMP levels, OxyHb inhibited the expression of MT1-MMP. r-MT1-MMP activated the r-MMP-13, but SNAP did not, TIMP-2 inhibited the activity of r-MMP-13 induced by r-MT1-MMP. Conclusions NO can not directly activate pro-MMP13 by the role of S-nitroso-(S nitrosylation). MT1-MMP mediates the activiation of pro-MMP-13 induced by NO.

In this paper the last study of the role of nitric oxide(NO) in the development of osteoarthritis is reported. The study of dependability of the content of NO in the inflamed tissue and development of osteoarthritis showed that NO had an important role in the damage of cartilage,and that the inhibition of excess release of NO could improve the repair of cartilage,and that the effective inhibitor of nitric oxide synthase might cure osteoarthritis.

OBJECTIVE:To provide suggestions for dealing with public emergency in China. METHODS:Through consulting the FDA guidelines for emergency management,the study was done by reviewing literature and comparison study. RESULTS:USA has established complete legal system for emergency management. FDA has established complete organization chart of emergency response with the emergency operation center as its focal point and various centers and offices providing support to resolve all kinds of emergencies. CONCLUSIONS:A complete legal system for emergency management is required in China,the most importance of which is to set up an emergency operation center in SFDA with a set of supporting departments. It is urgent to establish practical emergency response plans.

OBJECTIVE:To provide suggestions for the revision of regulations on drug import and export stated in Pharmaceutical Management Law.METHODS:The Federal Food,Drug and Cosmetic Act(FD&CA) and regulations and procedures on drug import & export were reviewed.Then literature analysis and comparison research were adopted in study.RESULTS:Complete legal system for drug import and exports were established in USA.With multiple revision and supplement,items in FD&CA were comprehensive and explicit,which standardized the behavior of import and export and increased sales.CONCLUSIONS:The management for drug import and export should further be strengthened in China with a focus on improving Pharmaceutical Management Law.The most important thing is to implement full supervision on drug imports with flexible import procedure and regulations,and enhance the management for exporting drugs and specific medicines.