1.Advances in familial pancreatic cancer
Journal of International Oncology 2011;38(4):292-295
Familial pancreatic cancer is a known hereditary cancer syndrome with autosomal dominant inheritance and accounts for about 3% of all pancreatic cancers. With the development of molecular genetics,several genes have been identified related with the familial pancreatic cancer, including breast cancer susceptibility gene 2, Palladin, cyclin-dependent kinase inhibitor 2A, et al. In particular, mutations in some of these genes have been defined as the hereditary basis of particular cancer syndromes. Molecular genetics surveillance for high risk populace can lead to the diagnosis of asymptomatic, early-stage pancreatic cancer or precancerous lesions.
2.Association between γ-glutamyl transpeptidase-to-platelet ratio and hepatic fibrosis in patients with chronic hepatitis B
Journal of Clinical Hepatology 2017;33(3):548-552
Early and accurate diagnosis of hepatic fibrosis and application of antiviral therapy are the key to improving the prognosis of patients with chronic hepatitis B (CHB).Liver biopsy and transient elastography cannot be widely used for the diagnosis of hepatic fibrosis in clinical practice,and therefore,the serological diagnostic model has become a hot research topic in recent years.This article introduces a new serological diagnostic model,γ-glutamyl transpeptidase-to-platelet ratio (GPR),which has a high value in the diagnosis of hepatic fibrosis in CHB patients;however,the accuracy of GPR varies between different populations and different areas.GPR is also an excellent predictor for the prognosis of hepatitis B-associated liver cancer.It is pointed out that GPR has a promising future in the diagnosis of hepatic fibrosis in CHB patients,but due to a lack of clinical research data on GPR,further studies are needed to support its application in China.
3.Research on the Feasibility of Enhancing the Concept of Rule of Law of the College Students by the Spirit of Contract
Chinese Medical Ethics 2016;29(5):898-901
The spirit of contract, with freedom, equality and reciprocity of power and responsibility as basic connotation and containing credit consciousness, is the core content of the concept of rule of law. People′s desire for justice, recognition of fairness, reliance on integrity contained in the concept of rule of law all originate from the spirit of contract, such as contract party's expectation of fairness, performance of obligation, abiding by the valid contract. Not only does the concept of rule of law reflect the essence requirement of the spirit of contract, but also is the external form of realization. Therefore, in order to enhance the concept of rule of law of the college students, it is a certain choice to cultivate the spirit of contract. However, the current paths to cultivate the spirit of contract are mainly theoretical research, environmental influence and system perfection.
4.Application of Neural Network Method on the Quantitive Structure-Activity Relationship of Quinolones Compounds
China Pharmacy 2001;0(07):-
OBJECTIVE:To study the quantitative structure-activity relationship of quinolones compounds by neural network(NN)method.METHODS:A3-layered BP neural network was constructed with the Matlab software package,the collected data were calculated,result of which was compared with that of the linear regression.RESULTS:Sum of square of errors for the neural network method was0.3042,which was less than that of linear regression;the predicted correlation co-efficient was0.86.CONCLUSION:The neural network method has achieved more precise fitting results than the linear re-gression in the study of the quantitative structure-activity relationship of quinolones compounds.
8.Reninoma
Chinese Journal of Practical Internal Medicine 2001;0(10):-
A reninoma is a renal juxtaglomerular cell apparatus tumor that produces excessive amounts of renin,resulting in secondary hyperaldosteronism,and associated hypertension and hypokalemia.It is a rare form of secondary hypertension and occurs mainly in young adult females.Common symptoms include headache,nocturia,polyuria,polydipsia,and fatigue.Imaging examination and selective renal vein sampling has been the traditional method of localizing the tumour.The diagnosis should be considered in all patients with hypertension and hypokalemia and no evidence of primary hyperaldosteronism and renal artery stenosis.Reninoma represents a surgically correctable cause of hypertension.
9.Discovery of natural triploid variations of Dioscorea zingiberensis and its evaluation of main economic qualities
Chinese Traditional and Herbal Drugs 1994;0(09):-
Objective The main economic qualities of natural triploid were evaluated and the result laid a foundation to culture new triploid variety of Dioscorea zingiberensis. Methods The ploidy level of series of D. zingiberensis from some areas of Yunnan Province were identified and the qualities of outputs per plantlet,propagation ratio,and diosgenin content etc. were measured. Results Five natural triploids were found and the qualities of the triploids all displayed diversity,output per plantlet 1 090.00—628.57 g,propagation ratio (ploidy) 72.43—29.43,dry substance ratio 36.95%—24.06%,and diosgenin content 4.40%—1.50%. The outputs of series 1 and series 3 exceed 1 000 g,the diosgenin content of series 2 reached to 4.40%,and series 3 displayed excellent quality of outputs per plantlet,propagation ratio,and diosgenin content. The synthetical index is maximum. Conclusion The series comprising good quality are obtained by the discovery of triploid and evaluation of qualities. The triploid variety is to be created with judgment and selection of progeny.
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