Familial pancreatic cancer is a known hereditary cancer syndrome with autosomal dominant inheritance and accounts for about 3% of all pancreatic cancers. With the development of molecular genetics,several genes have been identified related with the familial pancreatic cancer, including breast cancer susceptibility gene 2, Palladin, cyclin-dependent kinase inhibitor 2A, et al. In particular, mutations in some of these genes have been defined as the hereditary basis of particular cancer syndromes. Molecular genetics surveillance for high risk populace can lead to the diagnosis of asymptomatic, early-stage pancreatic cancer or precancerous lesions.

Animals ; China ; Culex ; Insect Vectors ; Longitudinal Studies

Aged ; Diagnosis, Differential ; Humans ; Intermittent Claudication ; diagnosis ; etiology ; Male ; Middle Aged ; Nervous System Diseases ; complications ; diagnosis ; Vascular Diseases ; complications ; diagnosis

China ; Encephalitis Virus, Japanese ; genetics ; immunology ; isolation & purification ; Encephalitis, Japanese ; virology ; Humans ; Research ; trends

Animals ; Arbovirus Infections ; prevention & control ; virology ; Arboviruses ; growth & development ; Biomedical Research ; methods ; standards ; trends ; China ; Humans ; Insect Vectors ; virology

The syndrome of inappropriate antidiuretic hormone secretion ( SIADH ),characterized with dilutional hyponatremia,is the most frequent pathophysiology of euvolemic hyponatremia in hospital inpatients.Conventional therapies for SIADH include fluid resriction,saline infusion,and some pharmacologic adjustments of fluid balance.For various reasons,conventional therapies show poor efficiency.Vasopressin receptor antagonist,a new class of pharmacologic agent,can directly block vasopressin-mediated receptor activation and target underlying pathophysiology of SIADH.

Objective To explore the influence of telephone follow-up on home rehabilitation for patients with schizophrenia. Methods 200 patients with schizophrenia were assigned into experimental group and control group with 100 cases in each group. During their hospitalization,all patients were given conventional treating and nursing and were treated with atypical antipsychotic drugs. After getting a clinical recovery and discharge, the experimental group received telephone follow-up for 2 years while the control group received outpatient service follow-up. Results There was significant difference in scores of Positive and Negative Syndrome Scale (PANSS) in both groups with time (F=85.943, P=0.000). There was a significant interaction effect between intervention and time (F=6.458, P=0.000) and there was also a significant difference (F=26.012, P=0.000) between both groups on the scores of PANSS. At the end of the 6th, 12th, 18th and 24th month after discharge, the PANSS scores were significantly less in the experimental group than in the control group (P<0.05). The accumulative total relapse rate and frequency were significantly lower in the experimental group than in the control group anytime after discharge (P<0.05).Conclusion The telephone follow-up can significantly improve the effect of home rehabilitation for the patients with schizophrenia. It is beneficial for the patients to control disease and reduce the relapse.

Healing garden, as an auxiliary medical technology for autism, presents the characteristics of integrity, controllability, compatibility and nature, which make up for the inadequacy of the current indoor intervention therapy. By way of natural benefit, active support,environmental integration and integrated therapy, it completes stage progressive system intervention and promotes sustainable development in body and mind.

Objective: To study TLR4 expression in human prostate cancer PC3 cells and the related intracellular signaling mechanisms. Methods: Human prostate cancer PC3 cells were stimulated with TLR4-specific ligand lipopolysaccharide (LPS), then the cells and supernatants were collected 0, 2, 6, 12, 24, and 48 hours after LPS stimulation. TLR4 mRNA and protein expression was examined by reverse transcription-PCR and Western blotting analysis, respectively. The mRNA expression of TGF-β, VEGF, 1L-8, COX-2, and MMP3 was also measured by reverse transcription-PCR, and the levels of VEGF, IL-8 in the supernatants were examined by ELISA. To further study the related signaling pathway, MAPK and NF-κB signaling pathways were blocked by specific inhibitors in PC3 cells before LPS stimulations the cells were collected after 4 hours and the supernatants were collected after 24 hours; and the above mentioned factors were examined by reverse transcription-PCR and ELISA again. Results: TLR4 expression was up-regulated by LPS stimulation in human prostate cancer PC3 cells, which significantly increased mRNA expression of TGF-β, VEGF, IL-8, COX-2, and MMP3 and secretion of VEGF and IL-8 in the supernatants (P<0.05); further study showed that p38 MAPK and NF-κB signal pathways were involved in the process. Conclusion: TLR4 signaling promotes VEGF and IL-8 secretion through p38 MAPK and NF-κB signal pathways.

The spirit of contract, with freedom, equality and reciprocity of power and responsibility as basic connotation and containing credit consciousness, is the core content of the concept of rule of law. People′s desire for justice, recognition of fairness, reliance on integrity contained in the concept of rule of law all originate from the spirit of contract, such as contract party's expectation of fairness, performance of obligation, abiding by the valid contract. Not only does the concept of rule of law reflect the essence requirement of the spirit of contract, but also is the external form of realization. Therefore, in order to enhance the concept of rule of law of the college students, it is a certain choice to cultivate the spirit of contract. However, the current paths to cultivate the spirit of contract are mainly theoretical research, environmental influence and system perfection.