In vitro synergistic activity of augmentin and amikacini sulfas, gentamicini sulfatis, cefazolinum natricum cloxacillinum natricum against 162 strains organism isolated from the clinical laboratories in Beijing were investigated. The results showed: At 8mg/L clavula-nic acid and 16mg/L amoxicillin of augmentin. Combined with 4 antibiotics against staphylococcus aureus, klebsiella pneumoniae shi-gella dysenteriae were showed 100% synergistic activity. The combination of augmentin and gentamicini sulfatis and amikacini sulfas against proteus vulgaris showed: Synergistic in 80% and 85%; against Escherichia coli synergistic in 93.33%; against Enterobacter cloacae synergistic in 17.86% and 42.86%, the combination of augmentin and cefazolinum natricum against Escherichia coli and proteus synergistic in all 100% and 85%.The combination of augmentin and cefazoliinum natricum against enterobacter cloacae in 100% antagonism.