Objective To investigate the influence of hospital-community integrated management mode on self behavior and blood glucose level in patients with typeⅡdiabetes .Method Three hundred and thirty-six patients with type II diabetes were treated with hospital-community integrated management. The index of biochemical indicators and self behaviors were compared between pre-and post-intervention.Result After intervention,the patients had improvements not only in medication compliance,rationale dieting,regular examination and self monitoring and physical exercises,but also in the indexes of biochemical indicators including fasting blood glucose(FBG),2 hour postprandial blood glucose(2 hBG), glycosylated hemoglobin(HbA1 c),(all P<0.05).Conclusion The hospital-community integrated management mode is helpful for the patients to form a right behavioral pattern and thus promoting the normalizations of biochemical indicators.

Objective To study the effects of pulse pressure (PP) on coronary artery disease. Methods High and low systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were measured in 221 cases with coronary heart disease diagnosed by coronary artery radiography, and the differences of coronary artery count, score, and clinic features were analyzed. Results ① Compared with low SBP group \[81mmHg)) were older in age, with higher percentage of females and lower incidence of unstable angina pectoris(UA) and acute myocardial infarction(AMI). ② Compared with low PP group(

The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumors found in various organs, remains to be identified. Here, based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase (FAK) in The Cancer Genome Atlas datasets that contain 9193 patients of 33 cancer subtypes, we found that Box 6/Box 7-containing FAK variants (FAK^6/7) were observed in 7 (87.5%) of 8 pancreatic neuroendocrine carcinomas and 20 (11.76%) of 170 pancreatic ductal adenocarcinomas (PDACs). We tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumors, and found that FAK^6/7 was positive in 34 (75.6%) of 45 pancreatic NENs, 19 (47.5%) of 40 pancreatic solid pseudopapillary neoplasms, and 2 (2.9%) of 69 PDACs. We further tested FAK splicing variants in breast neuroendocrine carcinoma (BrNECs), and found that FAK^6/7 was positive in 14 (93.3%) of 15 BrNECs but 0 in 23 non-NEC breast cancers. We explored the underlying mechanisms and found that a splicing factor serine/arginine repetitive matrix protein 4 (SRRM4) was overexpressed in FAK^6/7-positive pancreatic tumors and breast tumors, which promoted the formation of FAK^6/7 in cells. These results suggested that FAK^6/7 could be a biomarker of NENs and represent a potential therapeutic target for these orphan diseases.
Female ; Humans ; Alternative Splicing ; Breast Neoplasms/metabolism* ; Carcinoma, Pancreatic Ductal/pathology* ; Focal Adhesion Protein-Tyrosine Kinases/therapeutic use* ; Nerve Tissue Proteins/genetics* ; Neuroendocrine Tumors/genetics* ; Oncogenes ; Pancreatic Neoplasms/metabolism*