1.Significance of c-erbB-2 protein expression on the prognosis of gastric carcinoma:a Meta-analysis
Guiping QIN ; Xian LU ; Guangqiang QI ; Chengyi QU ; Jianfang LIANG ; Shiying LI
Basic & Clinical Medicine 2006;0(09):-
Objective To evaluate the association of c-erbB-2 protein expression with the prognosis of gastric carcinoma. Methods Eleven literatures were analyzed which published in recent 15 years on the relationship of c-erbB-2 with prognosis quantitively by software RevMan. Results The pooled odds ratio(OR) of 5-year survival rates was 0.69(95% CI:0.54~0.87)for all 11 literatures. The pooled odds ratio(OR) of three literatures from eleven literatures was 0.67(95%CI:0.48~0.94)which 5-year survival rates was determined as final index and OR as associated.For well-differentiated and advanced gastric carcinoma, the pooled odds ratio(OR) of 5~year survival rates were 0.18(95%CI:0.09~0.38)and 0.72(95%CI:0.47~1.09)respectively.Conclusion The association of c-erbB-2 expression with prognosis of gastric carcinoma is negative.
2.Polymorphism of angiotensin-converting enzyme gene I/D of broad jumpers
Kun ZHANG ; Xue JIANG ; Guiping XIAN ; Xiaochuan HU ; Junying ZHANG ; Hao YANG ; Dawei YU ; Wenqian DENG ; Xiaozhen DAI
Chongqing Medicine 2015;(1):18-20
Objective To explore the characteristic of ACE gene I/D polymorphism in Han broad jumpers .Methods Distribu‐tion of ACE gene I/D polymorphism for broad jumpers was analyzed by PCR ,DNA sequencing ,Hardy‐Weinberg and SPSS ,and the results were compared with that of normal people .Results There were II ,DD and ID in gene ACE 16 ,and the Hard‐Weinberg re‐sults showed that the subjects were group representative .The ACE DD genotype and D allele in broad jumpers was statistically higher than normal controls (P<0 .05) .Conclusion The results suggest that ACE DD genotype and D allele are associated with training sensitivity of broad jumpers and could be the molecular marker for athletes choosing genetically .