Objective To investigate the influence of individual psychological intervention on quality of life of HIV infection / AIDS patients.Methods 50 cases diagnosed as HIV infection / AIDS were selected,randomly divided into the control group and the observation group with 25 cases in each group.The control group received routine treatment and care,while for the observation group,the psychological health and quality of life were measured with SCL-90,SF-36 scales,then personalized psychological intervention was implemented after analyzing the influencing factors.Three months after discharge,the assessment test was carried out using SCL-90 and SF-36 scales,then compared the quality of mental health and life situation of the two groups.Results Mental health and quality of life between the observation group and the control group before intervention was not statistically significant.After intervention,the comparison is statistically significant Conclusions Individualized psychological intervention can improve patients quality of life.

OBJECTIVETo study the effect of erythropoietin (EPO) on the activities of antioxidant enzymes, namely catalase (CAT) and glutathione peroxidase (GSH-Px) in the brain tissues of aged rats.

METHODSThirty SD rats were randomly divided into normal control, aging model, and recombinant human erythropoietin (rhEPO) treatment groups (n=10). Morris water maze was used to compare the behavioral indexes. The rats were then sacrificed to observe Nissl bodies in the hippocampal neurons with Nissl staining and test the activities of CAT and GSH-Px in the brain tissues.

RESULTSCompared with the control group, the aging rats showed significantly deteriorated learning and memory abilities (P<0.05), which were improved obviously by rhEPO treatment (P<0.05). The number of Nissl bodies in the neurons was reduced in the aging rats compared with that in the control group, and rhEPO treatment increased the number of Nissle bodies but failed to restore the control level. The aging rats also showed significantly lowered activities of CAT and GSH-Px in the brain tissue (P<0.05), which were increased significantly after rhEPO treatment (P<0.05).

CONCLUSIONEPO can enhance the activities of the antioxidant enzymes in the brain tissues of aged rats to increase the antioxidant capacity and produces an anti-aging effect.

Aging ; Animals ; Brain ; enzymology ; Catalase ; metabolism ; Epoetin Alfa ; Erythropoietin ; pharmacology ; Glutathione Peroxidase ; metabolism ; Learning ; drug effects ; Male ; Memory ; drug effects ; Nissl Bodies ; drug effects ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins ; pharmacology