OBJECTIVE To investigate the related factors of hospital-acquired infection in our hospital for prevention and control of infection.METHODS We carried out a prospective and retrospective study of 26 424 hospitalized patients in our hospital from Jan to Dec 2006.RESULTS From then 1261 patients had hospital-acquired infection(4.77%),the total infection case-time was 1380(5.22%).CONCLUSIONS Hospital-acquired infection is closely related to patients,underlying diseases,old age,invasive procedure,hospital stay and inappropriate antimicrobial agents use.It requires us to strengthen the surveillance of hospital-acquired infection,decrease the unnecessary invasive procedures,shorten hospital stay and use antimicrobial agents appropriately.

OBJECTIVE To study characteristics of hospital infection and bacterial resistance in our neurosurgery ward to make us reasonable antibiotics use and supply the scientific basis for hospital infection control.METHODS The data of 1100 inpatients in our neurosurgery ward in 2007 were analyzed prospectively and retrospectively.RESULTS The hospital infection rate was 11.91%,the case-time infection rate 12.55%,the lower respiratory tract infection rate 69.57%,the G-infection rate 54.44%,the G+ infection rate 30%,and the fungus infection rate was 15.56%,These pathogens were resistant to antibiotics in various degree.CONCLUSIONS It is significant to continuously monitor hospital infection and bacterial resistance in our neurosurgery ward to guide reasonable antibiotics use and control hospital infection effectively.

OBJECTIVE To investigate which method for endoscope sterilization more convenient,qualified and with effectively elongating lifetime of endoscope usage.METHODS We used low temperature plasma hydroxide peroxide sterliization and 2% glutaraldehyde solution to sterilize endoscope and compared their effects.RESULTS Two methods were qualified for the requirements of serilization.Endoscope sterilization time with glutaraldehyde solution and low temperature plasma hydroxide peroxide was 10h and 55min,respectively.Sterilization-related endoscope attrition rate was 0.17% and 0,respectively,and showed significant difference(P

OBJECTIVE To find out the hand hygiene compliance among medical staff of our hospital,and discuss how to reduce the hospital infection.METHODS The questionnaires designed by ourself were used to observe the hand hygiene compliance on the scene and the hand hygiene knowledge among 120 Medical persons from 30 clinical departments and offices.RESULTS 81.7% Of the medical staff had accepted the education of the hand hygiene knowledge;89.2% of the medical staff considered washing hands could reduce the hospital infection.Only 2.5% of them considered hand hygiene had no relation to clinical treating result.30.8% Of medical staff washed their hands before contacting patients and 49.2% of them washed their hands after contacting patients.It showed significant difference between the two groups(P

OBJECTIVE To investigate the causes of fever and risk factors in portal hypertensive patients after combined operation(devascularization+shunt).METHODS Forty five cases of portal hypertension(PHT) after combined operation were retrospectively and prospectively analyzed.RESULTS Complications caused 88% post operational fever.The most common cause was hydrothorax,hematocele or hydrops and infection in splenic recess.Long-term fever was related to liver function(P

AIM: To study the absorption and excretion of CT-707 in healthy male subjects. METHODS: Six healthy male subjects received a single 300 mg (120 μCi) oral dose of radio-labeled CT-707 as a suspension in a fasted state. Blood, urine and feces were collected. Radioactivity concentrations were measured by liquid scintillation counting (LSC). The pharmacokinetic parameters of total radioactivity in plasma were calculated by WinNonlin (Pharsight version 8.1) software according to the non-compartment model. The recovery rate of total radioactivity in urine and feces was calculated according to the weight and radioactivity concentration of urine and feces collected at each time interval. RESULTS: After a single 300 mg oral of radio-labeled CT-707 552 h (23 d) as a suspension in a fasted state, the mean AUC