Objective To explore clinical efficacy of Shenlingbaizhu decoction on immune status in patients with ulcerative colitis(UC).Methods 60 patients with UC were selected and divided into control group and experiment group evenly and randomly.Control group received treatment of salazosulfapyridine,while experiment group received treatment of Shenlingbaizhu decoction based on treatments of control group.Clinical efficacy,serum levels of IL-6 and IL-8,percentage of Treg cells in peripheral blood were observed and compared between two groups before and after treatments.Results Total clinical efficacy of experiment group was significantly higher than that of control group(P＜0.05)(90.00％ vs 76.67％);Serum level of IL-6 was decreased significantly in all patients(P＜0.05),more significantly in experiment group(P＜0.05)after treatment;Serum level of IL-10 increased significantly in experiment group after treatment(P＜0.05);Percentage of Treg cells increased significantly in experiment group after treatment(P＜0.05).Conclusion Combination therapy of salazosulfapyridine and Shenlingbaizhu decoction shows significantly better clinical effects than salazosulfapyridine alone,probably via regulating immune status.

Objective To observe the efficacy of omidazole in the treatment of trichomonal vaginitis.Methods 64 cases with trichomonal vaginitis were divided into two groups randomly.The experiment group(32 cases) was given ornidazole,while the control group was given metronidazole.Changes in symptoms laboratory tests,vaginal examination and adverse reactions were compared between the two groups.Results The efficacy of experiment group was significantly better than the control group( P ＜ 0.05).The experiment group's adverse reactions were sigenificantly less than the control group ( P ＜ 0.05 ).Conclusiou Ornidazole used in the treatment of trichormonal vaginitis shows a significant effect with long duration and less adverse reactions,so it's should be promoted.

Objective To master the status of iodine content in drinking water and iodine nutritional status of population before and after the salt iodine concentration reduction in 2012 in Meizhou City, and to provide a scientific basis for safety assessment of salt iodine content after adjustment of the policy.Methods Using stratified random sampling method, drinking water samples were collected, and iodide content was measured by cerous sulfate catalytic spectrophotometry.Urine samples of children aged 8-10 were collected, in which the iodide content was quantitatively tested by arsenic cerium catalytic spectrophotometry.Samples of household edible salt were collected to determine iodine content by direct titration in 2012 before (September 2011), and after the salt iodine concentration reduction (September 2012 and September 2013).Results A total of 422 water samples were measured, the median iodine content of water was 2.4 μg/L.The water iodine median was 2.1 μg/L in centralized water supply (n =163),and 2.9 μg/L in decentralized water supply (n =259), the difference was statistically significant (U =-2.526, P ＜ 0.05).Totally 800 and 803 urine samples of children aged 8-10 were collected in 2011 and 2012, median urinary iodine was 216.5 and 207.5 μg/L, respectively, which were higher than that in 2013 (n =807, 190.0 μg/L, x2 =17.040,24.868, all P ＜ 0.05).Urinary iodine ≥300 μg/L ratio was significantly decreased (2013 than 2011 and 2012,19.3％ (156/807) vs.26.5％ (212/800) and 24.5％ (197/803), x2 =6.363, 11.695, all P ＜ 0.05), and urinary iodine ＜ 100 μg/L rose in the proportion (2013 than 2011, 18.0％ vs.13.5％, x2 =6.045, P ＜ 0.05).A total of 2 410 household salt samples were tested, and the coverage rate of iodized salt, iodized salt qualified rate, the consumption rate of qualified iodized salt were all higher than 98.8％.Totally 800, 803 and 807 salt samples were collected in 2011, 2012 and 2013, the salt iodine medians were 31.0, 27.7 and 25.4 mg/kg, respectively, the difference between the salt iodine medians was statistically significant (H =91.422, P ＜ 0.05).Conclusions Iodine excess risk is significantly decreased, and the level of iodine nutritional status of the city's population is appropriate after the salt iodine concentration reduction in 2012.The salt iodine concentration adjusted is suitable and safe.

OBJECTIVETo study the community characteristics of Acanthopanax giraldii and its role and adaptability in the community.

METHODThe methods of community ecology were used to investigate vegetation composition in different sample plots and the number of the clumps and clonal ramets. The importance value of species and biodiversity index of each plot was calculated. The life form spectra in different community were counted. The chi-square test was applied to analyze the dependence degree of A. giraldii to other main shrub species in the community.

RESULTThe investigation had showed that A. giraldii community could be divided into three types. The number of A. giraldii population in each type had great difference. Statistical analysis had shown that there's no correlation between the growth of A. giraldii with biodiversity and no significant interspecific association between A. giraldii and other main shrub species in the community yet.

CONCLUSIONThe population growth of A. giraldii was sensitive to Sunshine. A. giraldii maybe has the biological characteristics for artificial planting as a single population.

China ; Ecosystem ; Eleutherococcus ; classification ; growth & development

ObjectiveTo explore the therapeutic effect and mechanism of dexamethasone combined with puerarin for treatment of paraquat (PQ) poisoned rats.Methods Thirty Sprague Dawley (SD) rats were divided by random number table into 5 groups: control, model, dexamethasone, puerarin and combined groups, 6 rats in each group. The PQ poisoned rat model was established by intraperitoneal injection of PQ 25 mg/kg (1 mL), while in the rat of the control group, the same volume of normal saline was injected intraperitoneally. After 2 hours, in the rat of dexamethasone group, 20 mg/kg dexamethasone in 1.5 mL was injected intraperitoneally, and in the rat of puerarin group, 100 mg/kg puerarin in 1.5 mL was injected intraperitoneally. In the rat of combined group, 20 mg/kg dexamethasone combined with 100 mg/kg puerarin in a total amount of 1.5 mL was injected intraperitoneally. In the control group and model group, 1.5 mL of normal saline was injected intraperitoneally. The above mentioned treatments were repeated once more 26 hours later. In 26-50 hours after modeling, urine was collected, and urine N-acetyl-beta-D-amino glycosidase enzymes (NAG) was tested; at the 50th, abdominal aortic blood was collected to test oxygen partial pressure (PaO2). The lung index, kidney index, and the levels of malonaldehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured in the left lung and kidney tissue homogenates separately; the right lung and kidney were
harvested to observe pathological changes under light microscope. Another 30 SD rats were treated the same as above measures but no sacrifice to observe 30-day survival rate in each group.Results The lung index, kidney index, NAG in urine, MDA and MPO levels in lung and kidney tissue homogenates in model group were significantly higher than those in the control group [lung index: 9.80±1.83 vs. 4.97±1.14, kidney index: 9.40±1.32 vs. 7.01±0.32, NAG (U·kg-1·day-1): 1.93±0.18 vs. 0.41±0.03, MDA of lung (nmol/mg): 1.04±0.15 vs. 0.28±0.10, MDA of kidney (nmol/mg): 1.39±0.16 vs. 0.66±0.13, MPO of lung (U/g): 1.14±0.08 vs. 0.81±0.06, MPO of kidney (U/g): 0.88±0.08 vs. 0.52±0.12]; while PaO2 [mmHg (1 mmHg = 0.133 kPa): 59.83±4.40 vs. 97.00±2.83] and SOD (U/mg): lung was 27.38±3.48 vs. 86.88±5.88; kidney was 24.18±3.74 vs. 57.86±6.14) were obviously lower than those in control group (allP < 0.05). After drug treatment was given, lung index (7.21±1.87), urine NAG (1.01±0.21) and MDA (lung was 0.49±0.09, kidney was 0.85±0.08), MPO (lung was 0.97±0.07, kidney was 0.68±0.10) in the puerarin group were significantly lower than those in model group, while PaO2 (82.17±5.38), SOD (lung was 68.99±6.51, kidney was 37.90±3.62) were remarkably higher than those in model group (allP < 0.05). The improvement in the indexes related to the kidney injury was not obvious in dexamethasone group and in the dexamethasone combined with puerarin group, while the lung and kidney pathological changes were lesser in extent in each of the above two treatment groups than those in model group. The 30-day survival rate in model group was significantly lower than that in control group (0% vs. 100.0%);the 30-day survival rates in control group, dexamethasone group, puerarin group and combined group were remarkably higher than those in model group (100.0%, 16.7%, 50.0% and 33.3% vs. 0%, allP < 0.05). But there were no statistical significant differences in the survival rates among those treatment groups (P > 0.05).Conclusions Dexamethasone can improve the prognosis of rats with acute paraquat intoxication, it can provide lung protection markedly, but cannot provide significant protective effect on kidney; puerarin has therapeutic effect on rats with acute PQ poisoning, it can provide not only lung protection but also kidney protection. The effect of treatment with dexamethasone combined with puerarin is not superior to that by using dexamethasone or puerarin alone.

OBJECTIVETo study age structure and medicinal parts biomass accumulation of Acanthopanax giraldii population in West Sichuan Plateau.

METHODThe methods of plant population ecology were applied to the study. The ramets of A. giraldii were collected in sample plot, survey the age, height, basal diameter and biomass of ramets,and also survey the number,stem bark height and length of the one-year-shoot growing in clonal ramets. Then statistically analyzed the survey data.

RESULTThe article revealed growth rule of A. giraldii population. The mortality rate of clonal ramets reached a peak after six years growth. The power exponential fuction could reflect the correlation of age to the height, basal diameter and biomass of ramets. The production of medicinal parts was stable between two to six years growth of clonal ramets.

CONCLUSIONSuggested to harvest medicinal parts after three years growth of the clonal ramets. The study could provide biologic basis to population management and sustainable harvest of A. giraldii.

Biomass ; Ecosystem ; Eleutherococcus ; chemistry ; growth & development ; Plant Extracts ; analysis ; Time Factors

OBJECTIVE：To provide assistance for the smooth implementation of classification management policies of retail pharmacies in Guangdong province and the scientific supervision of retail pharmacies by relevant departments. METHODS ：In this study，key interviews were conducted among 68 interviewees，involving experts from Guangdong drug regulatory department ，head of retail pharmacies and research experts on relevant policies of universities. The current situation ，problems and suggestions of the classification management policy of retail pharmacies in Guangdong province were summarized. RESULTS & CONCLUSIONS ： The implementation of the classification management policies for retail pharmacies in Guangdong province operated well. Drug regulatory authorities at all levels could conduct daily supervision in accordance with policy requirements. Retail pharmacies operated in strict accordance with the classification management policy and established a relatively complete quality management system. However ，there were still problems such as difficulty in policy implementation ，insufficient policy clarity ，increased regulatory pressure and regulatory risks from government regulatory agencies ，rising operating costs and increasing pressure in retail pharmacies，the large gap of licensed pharmacists ，difficult to investigate and deal with “affiliation of certificate ”behavior，and difficult survival for remote pharmacies ，and the impact on the convenience of drug use of the public. It is suggested to improve the content of the policy ，introduce related supporting measures ，strengthen the construction of the supervisory team ，increase policy publicity，improve the ways and methods to investigate and deal with the “affiliation of certificate ”behavior of licensed pharmacists， and help retail pharmacies to diversify their operations and chain operations. It is recommended that relevant government departments should further improve the content of the policy and actively adjust the supervision methods to make the policy better implemented.