ObjectiveTo explore the influence of mental abacus calculation (MAC) training on children's form recognition.Methods 28 children ( 14 children with MAC training and 14 children with non-MAC traning)were investigated by using event-related potential(ERP) technology.The event-related potentials were recorded when subjects were in the different form shape recognition.Results ( 1 ) The amplitudes of the posterior P1 evoked by the children with MAC training ( (9.59 ± 3.58) μV) were significantly greater than that of the children without MAC training ( (7.06 ± 2.84) μV) ( P ＜ 0.05 ).(2) The amplitudes of right temporal-posterior N170 of children with MAC( ( -9.83 ±2.97) μV) were markedly less than that of children with non-MAC( ( - 12.45 ±2.51 ) μV) ( P ＜ 0.05 ).( 3 ) The amplitudes of prefrontal P3 of children with MAC ( (7.65 ± 2.25 ) μV) were remarkably greater than that of children with non-MAC ( (4.89 ± 3.35 ) μV) ( P ＜ 0.05 ).ConclusionThe brain function of form recognition in children is influenced by mental abacus calculation training.

Objective To study the impact of Chitosan Lecithin on the mild cognitive impairment(MCI) patients' semantic understanding by event-related potential N400.Methods 32 patients with MCI were screened from 500 elder people aged Court in Weifang by mini-mental state examination (MMSE) scale,and were divided into two groups:the observation group ( n=16) and the control group ( n=16) by the table of random numbers.The observation group were given Chitosan Lecithin while the control group were given an equal dose of placebo.The intervention time was 2 months.The subjects were asked to conduct semantic judgement by semantic violation experiment.Thirty-two channels electroencephalogram(EEG) was recorded by Neuroacan Nuamps Systerm and analyzed data.Results 1 ) Specific component N400 was found in both groups,which was distributed at the frontal,central and parietal regions.2 ) The observation group reaction time and correct rate were respectively (965.13 ± 178.07 ) ms and ( 92.56 ± 2.36 ) ％ ,while the control group were respectively ( 1126.13 ± 252.77 ) ms and (85.28 ± 5.73 )％,with significant difference(P ＜ 0.05 ).3 ) Compared with N400 in control group,N400 latency was shorter ( (425.28 ±47.26) ms vs (456.19 ± 37.75 ) ms,F=6.01,P＜0.05) and amplitude was higher ( (4.79 ±2.18)μV vs (3.59 ± 1.33) pV,F=5.96,P＜0.05).Conclusion Chitosan lecithin has the effect of N400 latency and amplitude,it may be helpful for the patients of MCI in semantic understanding.

Objective Tumor suppressor gene p53 can inhibit tumor cell growth, arrest cell cycle, and promote apoptosis.Howev-er, the effects of p53 on the pathogenesis of breast cancer have not been fully elucidated.The aim of this study was to explore the expression of p53 protein and the correlation with clinical pathologic features in breast cancer.Furthermore, the regulatory effects of 5-aza-2′-deoxycyti-dine on p53 in breast cancer cell line were also studied. Methods The expression of p53 protein in 80 cases of breast cancer and normal and adjacent tissue were determined by the immunohistochemical staining .The expressions of p53 mRNA and p53 protein in breast cancer cell line were determined by RT-PCR and Western blotting. Results The positive rate of p53 in breast cancer (41.25%) was higher than that in the normal and adjacent tissue (22.5%) (P<0.01).The expression of p53 was not significantly correlated with age, grade, stage and lymph node metastasis (P>0.05).The low expression of p53 both in mRNA and in protein levels were found in breast cancer cell line of MCF-7.The expres-sion of p53 increased after 5-aza-2′-deoxycytidine administration . Conclusion p53 is highly expressed in breast cancer , which may play an im-portant role in the development and progression of breast cancer. 5-aza-2′-deoxycytidine, up-regulating the p53 expression in breast cancer cell line, which provides the evidents for the development of therapeutic drugs for the patients with low expression of p53 breast cancer.

Objective To investigate application effect of fatigue factor intervention in breast cancer patients during operation.Methods A total of 60 breast cancer patients were ran-domly divided into observation group and control group.The control group received routine nursing while the observation group was given fatigue factor intervention based on the control group.Sur-gical efficacy,postoperative self-efficacy and life quality of two groups were compared.Results Fatigue degree score in the observation group was lower than that in the control group,postopera-tive complication and hospitalization time less than that in the control group,self-efficacy was higher than that in the control group,there were statistically significant differences(P <0.05). Life quality in the observation group was higher than that in the control group,there was statisti-cally significant difference(P <0.05).Conclusion Fatigue factor intervention is conducive to the postoperative recovery of breast cancer patients and it ensures the operation effect and improves the life quality.

Objective To investigate application effect of fatigue factor intervention in breast cancer patients during operation.Methods A total of 60 breast cancer patients were ran-domly divided into observation group and control group.The control group received routine nursing while the observation group was given fatigue factor intervention based on the control group.Sur-gical efficacy,postoperative self-efficacy and life quality of two groups were compared.Results Fatigue degree score in the observation group was lower than that in the control group,postopera-tive complication and hospitalization time less than that in the control group,self-efficacy was higher than that in the control group,there were statistically significant differences(P <0.05). Life quality in the observation group was higher than that in the control group,there was statisti-cally significant difference(P <0.05).Conclusion Fatigue factor intervention is conducive to the postoperative recovery of breast cancer patients and it ensures the operation effect and improves the life quality.

Objective? To analyze SCI papers related to palliative care and identify research hotspots to offer theoretical guidance and basis for further research and management of palliative care. Methods? SCI papers related to palliative care published on Web of Science from 1994 to 2017 were taken as the data source. Classified statistics, bibliometrics and CiteSpace II visualization software were used for relevant description and graphing. Results? The number and the cites of published SCI papers on palliative care began to rise substantially since 1994; the US ranked first in terms of the number of published papers, which was followed by China. Totally 24 high frequency keywords and 20 burst terms (research fronts) were found. The results showed that the subject of palliative care research turned from terminal stage patients to specific patients with chronic diseases and medical and nursing workers; psychological problems such as depression and sorrow in family care givers should draw more attention, and problem of races became a tendency as well. Conclusions? Palliative care related research has drawn attention from scholars at home and abroad. China's research in palliative care has a late start and remains in its infancy. Our scholars can use the experience of other countries as well as the advance care planning model of Taiwan Region of China for reference so as to find a palliative care model which is suitable for our conditions.

Objective:To explore influencing factors of acceptance degree of advance care planning (ACP) for cancer patients.Methods:Using the convenient sampling method, a total of 180 cancer patients who were diagnosed by histopathology or cytology in Liaoning Cancer Hospital and Institute from May 2019 to December 2019 were selected as the research objects. General data questionnaire, Patient's Advance Care Planning Acceptance Questionnaire (ACPQ) , Eysenck Personality Questionnaire-Revised Short Scale for Chinese (EPQ-RSC) and Social Support Rating Scale (SSRS) were used to investigate them and the influencing factors of ACP acceptance of cancer patients were analyzed.Results:A total of 180 questionnaires were issued in this study, including 173 valid questionnaires. The acceptance score of ACPQ for 173 cancer patients was (69.10±7.05) . The results of multiple linear regression analysis showed that education, residence, children's status, religious belief, length of time to know diagnosis, whether sanguine temperament and social support were the influencing factors for ACP acceptance of cancer patients ( P<0.05) . Conclusions:Cancer patients have an accepting attitude towards ACP and are willing to discuss ACP. The degree of acceptance is affected by many factors such as education level, residence, children's status, religious belief, length of time to know diagnosis, personality traits and social support. It is recommended that the popularization of relevant knowledge should be strengthened before the implementation of ACP, and the targeted population should be selected for trial.