Objective To evaluate the safety and efficacy of percutaneous balloon mitral valvuloplasty (PBMV) in patients with rheumatic severe mitral stenosis and thrombus in the left atrial appendage.Methods We selected 11 patients (9 women and 2 men), the average age being 40.6?5.7 years. All cases received warfarin orally every day for more than 12 weeks before underwent PBMV used Inoue single balloon technique, to see whether systemic thromboembolism complication occurred during the operation and one year follow-up term. Results The successful rate of PBMV was 100%. No systemic thromboembolism occurred during and after PBMV. The parameters of hemodynamics, mitral valve area and cardiac function improved markedly.Conclusion PBMV on patients with severe mitral stenosis and thrombus in the left atrial appendage is safe and effective after certain anticoagulation treatment.

Objective To identify the middle-long term outcomes,the incidence of restenosis,and the determining factors of restenosis.Methods Four hundred and sixty five patients with mitral stenosis (MS) underwent percutaneous balloon mitrail valvuloplasty (PBMV) from May 1990 to May 2002. Among the 465 patients,a retrospective study of 344 cases (258 females and 86 males) with complete data was presented in this article. The mean age was (40.2?9.6) years (ranging from 15 to 72 years). They were followed-up after PBMV. The data were analyzed with SAS software. Results Follow-up results of 1-12 years [median (3.6?2.5) years] showed that the one-year event-free survival rate was 100% with 9 cases of restenosis in 344 cases (2.5%),the three-years event-free survival rate was 97% with 39 cases of restenosis in 286 cases (13.6%),the five-years event-free survival rate was 91% with 60 cases of restenosis in 221 cases (27.1%),the eight-year event-free survival rate was 80% with 32 cases of restenosis in 81 cases (39.5%),and the ten-year event-free survival rate was 69% with 20 cases of restenosis in 42 cases (47.6%),and the twelve-year event-free survival rate was 63% with 9 cases of restenosis in 16 cases (56.3%). The event-free survival rate was greater in patients with modified echocardiographic score ≤10. Conclusion PBMV can produce good clinical middle and long-term outcomes in most patients,and those with modified echocardiographic score ≤10,bi-commissural splitting,sinus rhythm,large mitral valve area after PBMV,without poor cardiac function may especially have the best middle and long-term results.

OBJECTIVE:To investigate the occurrence features of adverse drug reactions(ADR)and evaluate the quality of ADR reports in our hospital in order to promote clinic rational drug use and improve the quality of ADR monitoring.METHO-DS:A total of 150 ADR cases collected in our hospital during 2005～2006 were analyzed in respect of ADR patients' age and sex,drug kinds,ADR-involved organs or systems and clinical manifestations,ADR report quality etc using Excel.RESULTS:The ADR were predominantly induced by antimicrobial drugs and characterized by the damage of skin and its appendants.The ADR reporting rate was on the low side and the reporting quantity remained to be enhanced.CONCLUSION:ADR monitoring and publicizing should be further reinforced and professional staff's responsibility awareness remains to be improved to lessen ADR incidence.

Objective To study the feasibility and long-term effects in 173 infants with congenital ventricular septal defect who underwent transcatheter therapy by double-disk ventricular septal defect occluder. Methods We analyzed the clinical data of 173 infants with ventricular septal defect who were performed interventional therapy followed by a follow up study from December 2002 to October 2013. Results The procedure was performed in 173 infants (male = 81 cases and female = 92 cases) aged 11 month-3 years[(2.1±0.7)years]. The weight were 6-15 kg[(10.2±3.6)kg]. The diameter of the defects ranged from 2.5-9.0 mm[(5.1±1.7) mm]. The characteristics of septal were classiifed into four types:the simply perimembranous ventricular septal defects (88 patient,50.8%), the perimembranous ventricular septal defects with pseudoaneurysm (52 patients, 30.0%), the perimembranous ventricular septal defects complicated with aortic valve prolapse (13 patients, 7.5%), and the intracristal ventricular septal defect (20 patients, 11.7%). The diameter of the occluders were between 4-12 mm[(6.3±2.2)mm]. The period of follow-up ranged from 1 month-10 years[(6.2±1.3)years]. The 168 defects were completely occluded in 173 patients(97.1%closure rate) except 5 infants, which 3 patients because the occluder hinder the function of aortic valves and the other occurred complete atrioventricular block(CAVB) when the catheter through defect. One patient occurred CAVB on the third day after the procedure, was reversed by dexamethasone after 4 days. 3 patients with complete left bundle branch block(CLBBB) after the procedure and one went to sustained, but did not observed heart failure in this case during 5 years follow-up. One patient observed sustained CLBBB on the fourth year after the procedure, also did not observed heart failure in this case during 3 years follow-up. 8 patients with trivial residual shun and 4 patients with newly appearance of trivial aortic regurgitation after the procedure, the shun all disappear at one year and the regurgitation did not progress during longest follow-up period at 8.5 years. No other complications, including late-onset CAVB, hematolysis, the occluder displacement and detachment, occurred during 1 month-10 years of follow-up. Conclusions Transcatheter closure of congenital ventricular septal defects is an efifcient method that can be safely used in the majority of infants with ventricular septal defects and have signiifcant long-term effects.

Objective To study the effect of Shensongyangxin Capsule on hemodynamics in the patients with chronic heart failure complicating ventricular arrhythmia .Methods A total of 126 patients with chronic heart failure complicating ventricular ar-rhythmia treated in this hospital from August 2013 to January 2016 were selected as the study subjects for conducting the prospec-tive study .The former 63 cases served as the observation group and the latter 63 cases as the control group .The control group were treated with conventional Western medicines .On the basis of the control group ,the observation group was auxiliarily given Shens-ongyangxin Capsule .Both groups were treated for 8 weeks .The curative effects and hemodynamics were compared between the two groups .Results The total effective rate in the control group was 85 .7% ,which was significantly lower than 96 .8% in the treat-ment group (P<0 .05) .The central artery pressure(MAP) was in the normal range before and after treatment in two groups ,the difference between the two groups had no statistical significance (P>0 .05) .The LVDd and LVDs values after treatment in the ob-servation group were significantly higher than those in the control group (P<0 .05) ,and the LVDd and LVDs values after treat-ment in the two groups were significantly higher than those before treatment (P<0 .05) .The QTcd values after treatment in the observation group and control group were significantly lower than those before treatment (P<0 .05) ,the QTcd values after treat-ment in the observation group were significantly lower than those in the control group (P< 0 .05) .Conclusion Shensonyangxin Capsule in the treatment of chronic heart failure complicating ventricular arrhythmia does not lead to the hemodynamic abnormali-ties ,promotes the heart function improvement and plays the antiarrhythmic effect and increases the curative effect .

Objective: To identify candidate predictors for the prognosis of cervical intraepithelial neoplasia 2 (CIN2) lesions and evaluate the prognostic value of the local immune response. Methods: One hundred fifteen CIN2 patients were enrolled. The percentage of p16-, minichromosome maintenance complex component 2- or apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G)-positive cells was determined immunohistochemically. Tumor-infiltrating lymphocytes (TILs) in intertumoral lesions were scored using an automated system. CIN3 disease progression and regression rates were estimated by the Kaplan–Meier method. A case-control study was conducted to screen CIN2 prognostic factors in 10 regression and 10 progression patients. Selected factors were examined in a cohort study to determine their prognostic value for CIN2. Results: Among all participants, the cumulative progression and regression rates at 60 months were 0.477 and 0.510, respectively. In the case-control study, p16- and APOBEC3G-positive cells were higher in the progression group (p=0.043, p=0.023). Additionally, CD4+ cell infiltration was enhanced in the regression group (p=0.023). The cohort study revealed a significantly increased progression rate in patients with elevated p16-positive cells (p<0.001), and increased CD4+ TIL infiltration was associated with better regression (p=0.011). Kaplan–Meier analysis according to human papillomavirus (HPV) positivity revealed a greater CIN3 development risk in HPV16-positive patients than in HPV16-negative cases. Finally, multivariate analysis identified HPV16 infection and CD4+ TIL infiltration as independent prognostic factors in CIN2 regression. Conclusion CD4+ TIL infiltration in intertumoral lesions was related with CIN2 regression. Our findings suggest CD4+ TIL infiltration may be useful for the triage of CIN2 patients.