1.Medical Ethics Adjustments of ART & Ethics Committee of Medical Organizations
Chinese Medical Ethics 1994;0(05):-
One of the important missions of modern medical ethics is to strengthen the adjustment of medical ethics and advance the infiltration of medical ethics spirits to medical science to solve the basic ethical problems caused by ART.The adjustment of Medical ethics on ART are affected through ethical regulation,exampling, leading, educating etc.Medical Ethics Committee is an important form of realizing this kind of function,and it is also the evidence of the system of medical ethics. It has been an international practice to set up ethics committee in order to carry on ethics supervision for relevant medical course.The application and development in a healthy way of ART in our country is calling for the ethics committee of medical organizations to play effective role.
2.Malformed macrocephalous sperm with polytails and chromosomal aberrance
Liqing FAN ; Wenbing ZHU ; Qingshan ZENG ; Yueqiu TAN ; Keli LOU ; Guangxiu LU
Chinese Journal of Medical Genetics 2001;18(1):28-31
Objective To investigate the relationship between sperm anomalies and chromosomal aberrance and to further understand the pathological changes of anomalous spermatozoa.Methods Light and electronic (SEM or TEM) microscopes were used for morphological analysis. Fluorescence in situ hybridization(FISH) with chromosome X-,Y-specific probes were used for aneuploidy detection in sperms of the patient. Results Ninety eight point seven five per cent of the Papanicolaou stained sperms were observed to be abnormal; 100% of the sperm heads were abnormal, measured under oil objective (1000×); 60.25% of the sperms had two or more tails (the maximum being eight tails). SEM and TEM demonstrated that the heads contained a large amount of cytoplasmic structure, the surfaces of heads were uneven, the nuclei were of much irregular shape; besides aberrance in quantity, anomalies occurred with centromeres, mitochondria and flagella in the tails. The results of FISH showed that the aneuploidy rate of sex chromosomes was 61.41% which was parallel to the rate of polytails.Conclusion Even though the chromosomes in somatic cells are normal, the chromosomes in anomalous sperms may be abnormal.