OBJECTIVE:To investigate the change in drug resistance of pseudomonas aeruginosa to imipenem bewteen Jan.2000and Jun.2005in the hospital where the authors work in order to provide the reference for rational choice of antibac-terials in clinic.METHODS:158strains of imipenem resistant pseudomonas aeruginousa had been isolated in clinic and their drug sensitivity to antibacterials was tested by KB slip diffusion method and analyzed statistically.RESULTS:Meropenem,amikacin,and ceftazidime were among the antibacterials that kept high antibacterial activity and had resistance rates less than35%included.CONCLUSIONS:Imipenem resistant pseudomonas aeruginosa strain has stronger resistance to commonly used antibacterials and its multidrug resistance is more severe.Rational use of antibacterials can help to control and lessen the drug resistance of bacteria.

The hospital took the lead in the area to carry out stroke process improvement, including the accountability practice of the president, micro-videos for illness condition description, standardized language communication, CT-room thrombolysis, and interdisciplinary seamless corporation among others. The timespan from admission to thrombolysis ( door to needle time, DNT) has shortened significantly, scoring the median time of 25 minutes and the shortest of 8 minutes. The hospital is also the first in the area to initiate the program to bypass the emergency department and the thrombolytic treatment on the ambulance. Such bypass program keeps the DNT of emergency patients within 15 minutes.