OBJECTIVE:To investigate the situation of the non-rational use of drugs in the outpatient and emergency department.METHODS:The prescriptions of outpatient and emergency department between Jan.2004 and Sept.2005 collected from Guilin Municipal Hospital of TCM were analyzed statistically.RESULTS:The irrational prescriptions represented 0.44% of the total prescriptions examined and verified.The non-rational use of drugs mainly manifested as improper usage,repeatedly administration,non-rational dosage,improper use of dissolvent,pharmacological antagonism and incompatibility etc.CONCLUSION:Some effective measures such as strengthening training of pharmacists,promoting the communication between pharmacists and physicians,developing careful work style etc should be taken to tackle the problem of non-rational use of drugs.

Objective To investigate the efficacy of damage control surgery for severe abdominal trauma.Methods The clinical data of 82 cases with severe abdominal trauma who received damage control surgery (DCS group) were retrospectively analyzed.The treatment conditions and treatment effect were analyzed.Another 82 cases with abdominal trauma who were not given damage control operation were considered as the control group.Results In DCS group,71 cases improved,the effective rate was 86.6％;11 cases deaths,mortality was 13.4％.4 cases had severe liver rupture,36h after surgery died of multiple organ failure ;3 cases of colon damage,1 d concurrent infections in the postoperative shock and died ;3 cases of retroperitoneal hematoma complicated with coagulopathy,died 20h after operation.In control group,82 cases of abdominal trauma patients after conventional treatment,73 cases improved,and the effective rate was 89.0％ ;9 deaths,mortality was 10.9％.71 patients of DCS group after resuscitation after ICU oxygen saturation,temperature,PH value,PT value and ICU resuscitation significantly improved compared with before treatment,the differences were statistically significant(t =2.467,2.449,2.738,2.453,all P ＜ 0.05),compared with the control group,the differences were not statistically significant (t =1.303,1.312,1.341,1.325,all P ＞ 0.05).Conclusion Damage control surgery for severe abdominal trauma achieved good effect,it is an effective treatment for severe abdominal trauma.

Objective: To observe the effect of Deanxit and Nimodipine on the headache of anxiety and depression neurosis. Methods:Fifty anxiety and depressive neurosis patients with headache were randomly divide into groups A and B. Group A: Daenxit and nimodipine therapy,group B: Deanxit therapy. All the patients were examined in TCD, Hamilton Anxiety Scale, Hamilton Depression Scale (HAMH、HAMD)and the chief symptom changes before and after therapy. Results: Eight weeks after therapy, the cerebral blood fluid in group A was improved,but it was insignificant in group B. The symptoms of anxiety,depression and headache in group A were much better improved than that of group B. Conclusion: Deaxit had a better anti-anxiety and antidepression function. Nimodipine could improve markedly headache less for anxiety and depression. It was more effect that synthetic therapy than single anti-anxiety and antidepression.

An in-depth analysis of the problems found in the hierarchical medical system,found that the research hospitals should focus on the conceptions of Big Times and Big Health,initiative the task to undertake Strong grass-roots,and actively build leading model of hierarchical medical system based on the PDCA cycle.At the same time,taking the practice of the 2nd Affiliated Hospital of Harbin Medical University as an example,we propose the research hospitals should strengthen service capabilities in primary health care institutions from talent,technology,management and other aspects, so as to enhance the patient's willingness to visit the grassroots,and to promote the further deepening of our medical reformation.

OBJECTIVE:To compare the dissolution rates of levofloxacin tablets produced in 4 domestic pharmaceutical manufacturers in order to provide the evidence for its clinical use.METHODS:UV spectrohpotmetry was used to determine the cumulative dissolution rates of these 4 kinds of levofloxacin tablets at different time points,the dissolution parameters of T50,Td,T80,and M were calculated by Weibull formula,then variance analysis was made.RESULTS:The dissolution rates of these 4 kinds of levofloxacin tablets all met the standards recorded in 2000 edition of China Pharmacopoeia,but significant differences were found in parameters of T50,Td,T80,and M(P

Objective To investigate the clinical efficacy and safety of recombinant tissue type plasminogen activator(rr-PA) and urokinase(UK) in the treatment of acute myocardial infarction (AMI).Methods According to the digital table,128 patients with AMI were randomly divided into two groups,64 cases in each group.The control group adopted UK intravenous thrombolytic therapy,while the observation group adopted rr-PA intravenous thrombolytic therapy.The recanalization condition at different time after thrombolytic therapy,the incidence rate of cardiovascular events and death rate were compared between the two groups.Results The recanalization rate at 30min,60min and 120min after thrombolysis of the observation group were 29.69 ％,59.38 ％ and 93.75 ％,respectively,which were significantly higher than 14.06％,35.94％ and 68.75％ of the control group(x2 =6.34,7.01,7.45,all P ＜ 0.05) ;The incidence rate of cardiovascular events and mortality rate of the observation group after thrombolytic therapy were 17.19％ and 4.64％,respectively,which were significantly lower than 40.63％ and 12.50％ of the control group (x2 =7.83,7.62,all P ＜ 0.05).Conclusion Recombinant tissue type plasminogen activator intravenous thrombolytic therapy has significant effect in the treatment of acute myocardial infarction after thrombolysis,which can reduce the incidence of cardiovascular events and mortality,with good clinical application value.

OBJECTIVE:To develop a HPLC assay for the determination of 7 kinds of amino acids in amino acid capsules by using online derivation and diode array detector.METHODS:The high performance chromatograph of liquid with the device of automatic derivation was employed as the automatic sampler.The samples were injected in the predefined procedure,and detected with the diode array detector.RESULTS:Good resolution of 7 kinds of amino acids was obtained,and the respective detectable concentration showed a good linear relationship with its peak area.CONCLUSION:The present method is convenient,well reproduced, highly sensitive,and accurate,therefore it can be widely used.

Objective:To investigate the corrosion fatigue strength of laser-welded specimens fabricated from commercially pure titanium (TA2) and titanium alloy(TC4). Methods:TA2 and TC4 were mechanically processed into a certain size and joined by laser welding. A fatigue testing machine was used to test tensile load and fatigue strength after soaked in synthetic saliva. The fatigue fracture surface was examined by scanning electron microscopy (SEM). Results: The fatigue strengths of the laser-welded test specimens showed no significant differences compared to specimens in air. SEM examination showed that there were no defects such as corrosion pits. Conclusion: There are no significant differences between either laser-welded metal in the corrosion fatigue strength for dry specimens and specimens in synthetic saliva.

BACKGROUND: Nervousness, anxiety and depression are important inducing factors of migraine, while nervousness, anxiety and depression are closely correlated with the unreasonable belief and incorrect strategy. Medicine therapy is the principal method in the treatment of migraine at present, but it cannot change the unreasonable belief of the patients and thereby to reducethe occurrence of the inducing factors of headache.OBJECTIVE: To observe the near term and long term therapeutic effects of medicine therapy and rational emotional behavior therapy(REBT) to provide a safer and more effective intervention for the patients with migraine and thereby to improve their long term quality of life(QOL).DESIGN: An observatory comparative study based on patients with migraine as subjects and healthy population as controls.SETTING: A psychological consultation clinic of a municipal hospital(has been canceled now).PARTICIPANTS: Totally 86 cases of migraine including 34 males and 52females aged between 16 and 48 years old(means of 35 years old) with a course of disease between 2 and 11 years were selected from the Psychological Consultation Clinic of the 289 Hospital between March 1999 and October 2001. All 86 cases were randomly divided into REBT group and medicine group with 43 cases each. There was no significant difference of age, gender,course of the disease, situation of the disease, and education background between two groups. Another 30 healthy individuals including 12 males and 18 females with a mean age of 36 years old were selected in control group.METHODS: REBT was applied for patients in REBT group. Patients of medicine group received 50-100 mg/day of Amitriptyline and 60 mg/day of nimodipine through oral administration. Patients received 12 weeks of therapy followed by 24 weeks of observation.MAIN OUTCOME MEASURES: Therapeutic scale score on migraine (TSSM), before and after migraine-correlated potential(P300) and symptoms checklist 90 (SCL-90) scores were compared.RESULTS: SCL-90 total points of two groups of patients were significantly higher than that of control group( P ＜ 0.05); after 12 weeks of therapy,TSSM, SCL-90 total points and points of major factors of two groups of patients were significantly lower compared with the situations before therapy( P ＜ 0.05), but there was no significant difference between two therapy groups; on the 12th week after therapy, SCL-90 total points, points for major factors and TSSM, and P300 latency of REBT group were almost as the same as that after 12 weeks of therapy and the wave amplitude of P300 significantly elevated; owever, the differences in SCL-90 total points, points of major factors, and the TSSM in medicine group were significant compared with that after 12 weeks of therapy( P ＜ 0.05) . There was significant difference at the same period between two therapy groups ( P ＜ 0.05).CONCLUSION: REBT can reduce the attacks of migraine, decrease TSSM,and has similar therapeutic effects to medicine group. Simultaneously, it can ameliorate the cognitive disorder, change the unreasonable belief of the patients, and improve the strategy to cope with the disease; hence its long term therapeutic effect is better than medicine therapy.

Objective To study the influence of ammoniummeta vanadate on the histological structure of jejunum of rats. Methods One hundred and twelve healthy and clean SD rats were randomly divided into the high dosage (60 mg/L),the moderate dosage(40 mg/L),the low dosage(20 mg/L) and the control group(distilled water),28 in each group,the males and females in the same number,the administration was conducted through drinking water,for 8 consecutive weeks. In the 4th and 8th weeks,the length of jejunum villus,the depth of jejunum gland and the thickness of jejunum wall were measured,the ratio of villus length and gland depth were counted and the pathological examination was done. Results With the increase of ammoniummeta vanadate,the weight of SD rats,the jejunum villus length,the depth of the jejunum gland,the wall thickness had showed a downward trend,the ratio of villus length and gland depth were significantly lower (P